Laura Vrbanac

Dr, PhD

  • 231 Citations
  • 5 h-Index
20052020

Research output per year

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Personal profile

Research Interests

Laura is a cancer biologist and a member of the Gut Cancer lab based at SAHMRI.  Headed by Dr Susan Woods, this lab works to identify, validate and translate new discoveries into clinical practice to help better detect and treat gastrointestinal cancers. 

Working in collaboration with numerous labs and hospitals across Adelaide and Australia, Laura uses organoid technology to grow individual patient samples, which are then maintained in a gastrointestinal organoid biobank.  This resource allows Laura and her colleagues to study and compare tumour organoids and assess personalised treatments for patients with advance disease.

Education/Academic qualification

PhD, Flinders University

Keywords

  • Gut Health, microbiome, gastrointestinal cancer, organoids

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Research Output

  • 231 Citations
  • 5 h-Index
  • 5 Article
  • 1 Review article

Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy

Narasimhan, V., Wright, J. A., Churchill, M., Wang, T., Rosati, R., Lannagan, T. R. M., Vrbanac, L., Richardson, A. B., Kobayashi, H., Price, T., Tye, G. X. Y., Marker, J., Hewett, P. J., Flood, M. P., Pereira, S., Whitney, G. A., Michael, M., Tie, J., Mukherjee, S., Grandori, C. & 4 others, Heriot, A. G., Worthley, D. L., Ramsay, R. G. & Woods, S. L., 6 May 2020, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Lannagan, T. R. M., Lee, Y. K., Wang, T., Roper, J., Bettington, M. L., Fennell, L., Vrbanac, L., Jonavicius, L., Somashekar, R., Gieniec, K., Yang, M., Ng, J. Q., Suzuki, N., Ichinose, M., Wright, J. A., Kobayashi, H., Putoczki, T. L., Hayakawa, Y., Leedham, S. J., Abud, H. E. & 10 others, Yilmaz, Ö. H., Marker, J., Klebe, S., Wirapati, P., Mukherjee, S., Tejpar, S., Leggett, B. A., Whitehall, V. L. J., Worthley, D. L. & Woods, S. L., 1 Apr 2019, In : Gut. 68, 4, p. 684-692 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Combination of Selenium and Green Tea Improves the Efficacy of Chemoprevention in a Rat Colorectal Cancer Model by Modulating Genetic and Epigenetic Biomarkers

Hu, Y., McIntosh, G. H., Le Leu, R. K., Nyskohus, L. S., Woodman, R. J. & Young, G. P., 23 May 2013, In : PloS one. 8, 5, e64362.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis

Vrbanac, L., Watson, A. J., Margison, G. P., Le Leu, R. K., Kim, S., Lockett, T. J., Head, R. J., Young, G. P. & Hu, Y., 12 Dec 2013, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 758, 1-2, p. 80-86 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon

Winter, J., Nyskohus, L., Young, G. P., Hu, Y., Conlon, M. A., Bird, A. R., Topping, D. L. & Le Leu, R. K., 1 Nov 2011, In : Cancer Prevention Research. 4, 11, p. 1920-1928 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)