• 236 Citations
  • 7 h-Index
20082018
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Personal profile

Public Profile

Research Focus 

Acute Lymphoblastic Leukaemia (ALL) is an extremely heterogeneous disease with subtypes of patients exhibiting a diverse range of genetic mutations. Certain subtypes of ALL can be treated with drugs already in clinical use. Laura undertook her Fulbright fellowship (2016-2017) at St. Jude Children’s Research Hospital in Memphis, Tennessee where she learned mouse models of high-risk ALL. Laura is now leading in vivo mouse studies for high-risk ALL with a specific focus on T-cell ALL. This project will assess targeted therapies in mouse models of ALL through ongoing generation of 1) patient derived xenografts from patient samples received in our laboratory and 2) transgenic models. This will enable the evaluation of novel and combination therapeutic approaches compared with the current standard of care. Mouse models of drug resistance will also be developed and pre-emptive intervention in the resistant disease setting investigated. These studies will ultimately inform clinical practice, impacting significantly on response to therapy and overall survival of adults and children with high-risk ALL. 

Education/Academic qualification

PhD, University of Adelaide

30 Mar 200927 Mar 2013

Bachelor's Degree (Honours), University of Adelaide

17 Jan 20062 Dec 2006

Bachelor's Degree, University of Adelaide

22 Jan 20032 Dec 2005

External positions

Post Doctoral Research Associate, St. Jude Children's Research Hospital

14 Aug 201615 Aug 2017

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Research Output 2008 2018

  • 236 Citations
  • 7 h-Index
  • 7 Article
  • 3 Letter
  • 1 Review article
1 Citation (Scopus)

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro

Eadie, L., Saunders, V., Branford, S., White, D. & Hughes, T., 2018, In : Oncotarget. 9, 17, p. 13423-13437 15 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Prizes

Australian Postgraduate Award

Laura Eadie (Recipient), 2008

Prize: Other distinction

Baillieu Supplementary Research Scholarship

Laura Eadie (Recipient), 2008

Prize: Other distinction

Biomedical Postgraduate Scholarship

Laura Eadie (Recipient), 2008

Prize: Other distinction

Activities 2016 2016

  • 2 Invited talk

18th Annual ESH-iCMLF International Conference on CML – Biology and Therapy

Laura Eadie (Speaker)
Sep 2016

Activity: Talk or presentationInvited talk

18th Annual ESH-iCMLF International Conference on CML – Biology and Therapy

Laura Eadie (Speaker)
Sep 2016

Activity: Talk or presentationInvited talk