• 262 Citations
  • 7 h-Index
20082020

Research output per year

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Personal profile

Public Profile

Research Focus 

Acute Lymphoblastic Leukaemia (ALL) is an extremely heterogeneous disease with subtypes of patients exhibiting a diverse range of genetic mutations. Certain subtypes of ALL can be treated with drugs already in clinical use. Laura undertook her Fulbright fellowship (2016-2017) at St. Jude Children’s Research Hospital in Memphis, Tennessee where she learned mouse models of high-risk ALL. Laura is now leading in vivo mouse studies for high-risk ALL with a specific focus on T-cell ALL. This project will assess targeted therapies in mouse models of ALL through ongoing generation of 1) patient derived xenografts from patient samples received in our laboratory and 2) transgenic models. This will enable the evaluation of novel and combination therapeutic approaches compared with the current standard of care. Mouse models of drug resistance will also be developed and pre-emptive intervention in the resistant disease setting investigated. These studies will ultimately inform clinical practice, impacting significantly on response to therapy and overall survival of adults and children with high-risk ALL. 

Education/Academic qualification

PhD, University of Adelaide

30 Mar 200927 Mar 2013

Bachelor's Degree (Honours), University of Adelaide

17 Jan 20062 Dec 2006

Bachelor's Degree, University of Adelaide

22 Jan 20032 Dec 2005

External positions

Post Doctoral Research Associate, St. Jude Children's Research Hospital

14 Aug 201615 Aug 2017

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Research Output

  • 262 Citations
  • 7 h-Index
  • 8 Article
  • 3 Letter
  • 2 Review article
  • 1 Short survey

The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL

Tavakoli Shirazi, P., Eadie, L., Heatley, S., Hughes, T., Yeung, D. & White, D., 18 Feb 2020, In : British Journal of Cancer. 122, 4, p. 455-464 10 p.

Research output: Contribution to journalReview article

High Risk Genomic Alterations Identified at the Time of Diagnosis Are Strongly Associated with MRD and Subsequent Poor Outcomes in AYA ALL Patients Treated on a Pediatric Inspired Chemotherapy Regimen

Yeung, D. T., Greenwood, M., Rhen, J., Heatley, S. L., McClure, B., Eadie, L. N., Breen, J., Schutz, C. S., Trahair, T. N., Wei, A. H., Dalla-Pozza, L., Sutton, R., Bradstock, K. F., Osborn, M. P. & White, D. L., 13 Nov 2019, In : Blood. 134, Supplement_1, p. 3949-3949 1 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Prizes

2019 Travel Grant

Laura Eadie (Recipient), 31 May 2019

Prize

File

Australian Postgraduate Award

Laura Eadie (Recipient), 2008

Prize: Other distinction

Baillieu Supplementary Research Scholarship

Laura Eadie (Recipient), 2008

Prize: Other distinction

Activities

  • 2 Invited talk

18th Annual ESH-iCMLF International Conference on CML – Biology and Therapy

Laura Eadie (Speaker)
Sep 2016

Activity: Talk or presentationInvited talk

18th Annual ESH-iCMLF International Conference on CML – Biology and Therapy

Laura Eadie (Speaker)
Sep 2016

Activity: Talk or presentationInvited talk