Josephine Wright

  • 1638 Citations
  • 14 h-Index
20022014
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Public Profile

Research Focus
Our lab has focussed on cancer biology to bring clinical impact.
To this end we have developed a translational network of labs and clinics across Adelaide, Australia and the world to identify, develop, translate and then validate new approaches to preventing and treating gastrointestinal cancer, particularly colorectal and gastric cancer. Our laboratory is based at SAHMRI, but we collect tissues and perform human studies across every major metropolitan public hospital in South Australia as well as St Andrews private hospital. We have established two biotech companies, and collaborate with researchers from Columbia University, Oxford University, Melbourne University and University of Queensland.
Our major projects at the moment are:
1. Engineering probiotics to detect and prevent colorectal cancer.
2. Identifying new therapeutic targets in the colorectal cancer stroma.
3. Developing new prevention and treatment for patients with an inherited form of gastric cancer, GAPPS.
4. Studying human tumour organoids to better personalise therapy in cancer.

Education/Academic qualification

PhD, University of Adelaide

20002004

Research Output 2002 2014

  • 1638 Citations
  • 14 h-Index
  • 16 Article
  • 2 Review article
  • 1 Short survey
79 Citations (Scopus)

MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways

Li, X., Roslan, S., Johnstone, C. N., Wright, J., Bracken, C. P., Anderson, M., Bert, A. G., Selth, L. A., Anderson, R. L., Goodall, G. J., Gregory, P. A. & Khew-Goodall, Y., 31 Jul 2014, In : Oncogene. 33, 31, p. 4077-4088 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

Bersten, D. C., Wright, J., McCarthy, P. J. & Whitelaw, M. L., 1 Jan 2014, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1839, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level

Wright, J., McHugh, P. C., Pan, S., Cunningham, A. & Brown, D. R., 1 Nov 2013, In : Molecular and Cellular Neuroscience. 57, p. 33-41 9 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-celllike state

Lim, Y. Y., Wright, J., Attema, J. L., Gregory, P. A., Bert, A. G., Smith, E., Thomas, D., Lopez, A. F., Drew, P. A., Khew-Goodall, Y. & Goodall, G. J., 1 May 2013, In : Journal of Cell Science. 126, 10, p. 2256-2266 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Prion protein expression alters APP cleavage without interaction with BACE-1

McHugh, P. C., Wright, J., Williams, R. J. & Brown, D. R., 1 Oct 2012, In : Neurochemistry International. 61, 5, p. 672-680 9 p.

Research output: Contribution to journalArticle