• 775 Citations
  • 15 h-Index
20092019
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Research Output 2009 2019

  • 775 Citations
  • 15 h-Index
  • 26 Article
  • 7 Review article
2019
2 Citations (Scopus)

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress

Xie, J., Van Damme, P., Fang, D. & Proud, C., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 18, p. 7169-7176 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

Jin, X., Merrett, J., Tong, S., Flower, B., Xie, J., Yu, R., Tian, S., Gao, L., Zhao, J., Wang, X., Jiang, T. & Proud, C., 15 Jan 2019, In : European Journal of Medicinal Chemistry. 162, p. 735-751 17 p.

Research output: Contribution to journalArticle

Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3

Zhou, Y., Li, Y., Xu, S., Lu, J., Zhu, Z., Chen, S., Tan, Y., He, P., Xu, J., Proud, C., Xie, J. & Shen, K., 8 Jul 2019, In : International Journal of Cancer. 146, 5, p. 1383-1395 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

Xie, J., de Souza Alves, V., von der Haar, T., O'Keefe, L., Lenchine, R. V., Jensen, K. B., Liu, R., Coldwell, M. J., Wang, X. & Proud, C. G., 4 Feb 2019, In : Current Biology. 29, 5

Research output: Contribution to journalArticle

5 Citations (Scopus)

The MAP kinase-interacting kinases (MNKs) as targets in oncology

Xie, J., Merrett, J. E., Jensen, K. B. & Proud, C. G., 4 Mar 2019, In : Expert Opinion on Therapeutic Targets. 23, 3, p. 187-199 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation

Charitou, T., Srihari, S., Lynn, M., Jarboui, M. A., Fasterius, E., Moldovan, M., Shirasawa, S., Tsunoda, T., Ueffing, M., Xie, J., Xin, J., Wang, X., Proud, C., Boldt, K., Al-Khalili Szigyarto, C., Kolch, W. & Lynn, D., 2 Jul 2019, In : British Journal of Cancer. 121, 1, p. 37-50 14 p.

Research output: Contribution to journalArticle

2018
5 Citations (Scopus)

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

Xie, J., Shen, K., Lenchine, R. V., Gethings, L. A., Trim, P. J., Snel, M. F., Zhou, Y., Kenney, J. W., Kamei, M., Kochetkova, M., Wang, X. & Proud, C. G., 1 May 2018, In : International Journal of Cancer. 142, 9, p. 1865-1877 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Who does TORC2 talk to?

Xie, J., Wang, X. & Proud, C. G., 24 May 2018, In : Biochemical Journal. 475, 10, p. 1721-1738 18 p.

Research output: Contribution to journalReview article

2017
3 Citations (Scopus)
8 Citations (Scopus)

Eukaryotic elongation factor 2 kinase (eEF2K) in cancer

Wang, X., Xie, J. & Proud, C., 1 Dec 2017, In : Cancers. 9, 12, 162.

Research output: Contribution to journalReview article

22 Citations (Scopus)

mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation

Fitter, S., Matthews, M. P., Martin, S. K., Xie, J., Ooi, S. S., Walkley, C. R., Codrington, J. D., Ruegg, M. A., Hall, M. N., Proud, C. G., Gronthos, S. & Zannettino, A. C. W., 1 Jan 2017, In : Molecular and Cellular Biology. 37, 7, e00668-16.

Research output: Contribution to journalArticle

2016
12 Citations (Scopus)

Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics

Shen, K., Lu, F., Xie, J., Wu, M., Cai, B., Liu, Y., Zhang, H., Tan, H., Pan, Y. & Xu, H., 1 Jan 2016, In : Oncotarget. 7, 31, p. 50596-50611 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells

Pan, W., Kremer, K. L., Kaidonis, X., Ludlow, V. E., Rogers, M. L., Xie, J., Proud, C. G. & Koblar, S. A., 1 Oct 2016, In : International Journal of Developmental Neuroscience. 53, p. 90-98 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

Moore, C. E. J., Wang, X., Xie, J., Pickford, J., Barron, J., Regufe da Mota, S., Versele, M. & Proud, C. G., 1 Apr 2016, In : Cellular Signalling. 28, 4, p. 284-293 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1

Shen, K., Xi, Z., Xie, J., Wang, H., Xie, C., Lee, C. S., Fahey, P., Dong, Q. & Xu, H., 1 Jan 2016, In : Oncotarget. 7, 35, p. 56650-56663 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

MTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GSCHOK1 cells

Jossé, L., Xie, J., Proud, C. G. & Smales, C. M., 1 Jan 2016, In : Biochemical Journal. 473, 24, p. 4651-4664 14 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

mTOR inhibitors in cancer therapy [version 1; referees: 3 approved]

Xie, J., Wang, X. & Proud, C. G., 1 Jan 2016, In : F1000Research. 5, 2078.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Quantitative non-canonical amino acid tagging (QuaNCAT) proteomics identifies distinct patterns of protein synthesis rapidly induced by hypertrophic agents in cardiomyocytes, revealing new aspects of metabolic remodeling

Liu, R., Kenney, J. W., Manousopoulou, A., Johnston, H. E., Kamei, M., Woelk, C. H., Xie, J., Schwarzer, M., Garbis, S. D. & Proud, C. G., 1 Oct 2016, In : Molecular and Cellular Proteomics. 15, 10, p. 3170-3189 20 p.

Research output: Contribution to journalArticle

2015
22 Citations (Scopus)

Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells

Shen, K., Xie, J., Wang, H., Zhang, H., Yu, M., Lu, F., Tan, H. & Xu, H., 1 Jul 2015, In : Molecular Cancer Therapeutics. 14, 7, p. 1738-1749 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Molecular mechanism for the control of eukaryotic elongation factor 2 kinase by pH: Role in cancer cell survival

Xie, J., Mikolajek, H., Pigott, C. R., Hooper, K. J., Mellows, T., Moore, C. E., Mohammed, H., Werner, J. M., Thomas, G. J. & Proud, C. G., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 10, p. 1805-1824 20 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Regulated stability of Eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity

Wang, X., Xie, J., Da Mota, S. R., Moore, C. E. & Proud, C. G., 15 Apr 2015, In : Biochemical Journal. 467, 2, p. 321-331 11 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding

Beggs, J. E., Tian, S., Jones, G. G., Xie, J., Iadevaia, V., Jenei, V., Thomas, G. & Proud, C. G., 1 Apr 2015, In : Biochemical Journal. 467, 1, p. 63-76 14 p.

Research output: Contribution to journalArticle

2014
44 Citations (Scopus)

Eukaryotic elongation factor 2 kinase activity is controlled by multiple inputs from oncogenic signaling

Wang, X., da Mota, S. R., Liu, R., Moore, C. E., Xie, J., Lanucara, F., Agarwala, U., Ruys, S. P. D., Vertommen, D., Rider, M. H., Eyers, C. E. & Proud, C. G., 1 Jan 2014, In : Molecular and Cellular Biology. 34, 22, p. 4088-4103 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/s6k1

Xie, J., El Sayed, N. M., Qi, C., Zhao, X., Moore, C. E. & Herbert, T. P., 1 Jan 2014, In : Journal of Molecular Endocrinology. 53, 1, p. 105-115 11 p.

Research output: Contribution to journalArticle

Signaling crosstalk between the mTOR complexes

Jianling, X. & Proud, C. G., 2014, In : Translation (Austin, Tex.). 2, 1, p. e28174

Research output: Contribution to journalReview article

2013
219 Citations (Scopus)

Cellular signalling of the receptor for advanced glycation end products (RAGE)

Xie, J., Méndez, J. D., Méndez-Valenzuela, V. & Aguilar-Hernández, M. M., 1 Nov 2013, In : Cellular Signalling. 25, 11, p. 2185-2197 13 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Crosstalk between mTor Complexes

Xie, J. & Proud, C., 1 Jan 2013, In : Nature Cell Biology. 15, 11, p. 1263-1265 3 p.

Research output: Contribution to journalArticle

2012
53 Citations (Scopus)

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)

Barlow, A. D., Xie, J., Moore, C. E., Campbell, S. C., Shaw, J. A. M., Nicholson, M. L. & Herbert, T. P., 1 May 2012, In : Diabetologia. 55, 5, p. 1355-1365 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2011
28 Citations (Scopus)

CAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

Xie, J., Ponuwei, G. A., Moore, C. E., Willars, G. B., Tee, A. R. & Herbert, T. P., 1 Dec 2011, In : Cellular Signalling. 23, 12, p. 1927-1935 9 p.

Research output: Contribution to journalArticle

2010
21 Citations (Scopus)

Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases

Méndez, J. D., Xie, J., Aguilar-Hernández, M. & Méndez-Valenzuela, V., 1 Nov 2010, In : Molecular and Cellular Biochemistry. 344, 1-2, p. 185-193 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Trends in advanced glycation end products research in diabetes mellitus and its complications

Méndez, J. D., Xie, J., Aguilar-Hernández, M. & Méndez-Valenzuela, V., 1 Aug 2010, In : Molecular and Cellular Biochemistry. 341, 1-2, p. 33-41 9 p.

Research output: Contribution to journalReview article

2009
33 Citations (Scopus)

Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

Moore, C. E. J., Xie, J., Gomez, E. & Herbert, T. P., 12 Jun 2009, In : Journal of Molecular Biology. 389, 3, p. 480-494 15 p.

Research output: Contribution to journalArticle