• 642 Citations
  • 13 h-Index
20092019
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Personal profile

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From the beginning of my PhD, my research interests have been mainly focused on delineating the cellular signalling pathways involving the mechanistic target of rapamycin (mTOR) complexes (mTORCs), which are multisubunit protein kinases. By regulating the protein synthesis machinery, mTORC1 serve as master controllers of cell growth, proliferation, survival and migration. After joining Professor Proud’s lab in Southampton, my work focused on two protein kinases highly related to the mTORC1 signalling pathways, especially the role of eukaryotic elongation factor 2 kinase (eEF2K) and the mitogen-activated protein kinases (MAPK)-interacting kinases (MNKs) in regulating protein synthesis. Stemming from those studies, my research interest has now evolved towards studying the role of MNKs in the propagation of tumour cells. Deregulation of the MAPKs and the MNKs signalling has been closely implicated in tumorigenesis and development. Genes implicated in the MAPK pathway (i.e. Ras, B-Raf and MEK) are well known to be oncogenic whose mutations have been commonly found in cancer patients and contribute to cancer progression. Indeed, inhibitors to the MAPK pathway have attracted a very high level of interest in academia and the pharmaceutical industry during the last decades.

Education/Academic qualification

PhD, University of Leicester

1 Oct 200813 Jul 2012

Masters, University of Leicester

1 Oct 200730 Sep 2008

Keywords

  • QP Physiology
  • RS Pharmacy and materia medica

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Research Output 2009 2019

  • 642 Citations
  • 13 h-Index
  • 23 Article
  • 7 Review article
1 Citation (Scopus)

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

Jin, X., Merrett, J., Tong, S., Flower, B., Xie, J., Yu, R., Tian, S., Gao, L., Zhao, J., Wang, X., Jiang, T. & Proud, C., 15 Jan 2019, In : European Journal of Medicinal Chemistry. p. 735-751 17 p.

Research output: Contribution to journalArticle

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

Xie, J., de Souza Alves, V., von der Haar, T., O'Keefe, L., Lenchine, R. V., Jensen, K. B., Liu, R., Coldwell, M. J., Wang, X. & Proud, C. G., 4 Feb 2019, In : Current Biology. 29, 5

Research output: Contribution to journalArticle

The MAP kinase-interacting kinases (MNKs) as targets in oncology

Xie, J., Merrett, J. E., Jensen, K. B. & Proud, C. G., 4 Mar 2019, In : Expert Opinion on Therapeutic Targets. 23, 3, p. 187-199 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

Xie, J., Shen, K., Lenchine, R. V., Gethings, L. A., Trim, P. J., Snel, M. F., Zhou, Y., Kenney, J. W., Kamei, M., Kochetkova, M., Wang, X. & Proud, C. G., 1 May 2018, In : International Journal of Cancer. 142, 9, p. 1865-1877 13 p.

Research output: Contribution to journalArticle

Who does TORC2 talk to?

Xie, J., Wang, X. & Proud, C. G., 24 May 2018, In : Biochemical Journal. 475, 10, p. 1721-1738 18 p.

Research output: Contribution to journalReview article