• 873 Citations
  • 17 h-Index
20092020

Research output per year

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Personal profile

Public Profile

From the beginning of my PhD, my research interests have been mainly focused on delineating the cellular signalling pathways involving the mechanistic target of rapamycin (mTOR) complexes (mTORCs), which are multisubunit protein kinases. By regulating the protein synthesis machinery, mTORC1 serve as master controllers of cell growth, proliferation, survival and migration. After joining Professor Proud’s lab in Southampton, my work focused on two protein kinases highly related to the mTORC1 signalling pathways, especially the role of eukaryotic elongation factor 2 kinase (eEF2K) and the mitogen-activated protein kinases (MAPK)-interacting kinases (MNKs) in regulating protein synthesis. Stemming from those studies, my research interest has now evolved towards studying the role of MNKs in the propagation of tumour cells. Deregulation of the MAPKs and the MNKs signalling has been closely implicated in tumorigenesis and development. Genes implicated in the MAPK pathway (i.e. Ras, B-Raf and MEK) are well known to be oncogenic whose mutations have been commonly found in cancer patients and contribute to cancer progression. Indeed, inhibitors to the MAPK pathway have attracted a very high level of interest in academia and the pharmaceutical industry during the last decades.

Education/Academic qualification

PhD, University of Leicester

1 Oct 200813 Jul 2012

Masters, University of Leicester

1 Oct 200730 Sep 2008

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Research Output

  • 873 Citations
  • 17 h-Index
  • 29 Article
  • 7 Review article

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K., Trim, P., Snel, M., Kamei, M., Martin, S., Fitter, S., Tian, S., Wang, X. & 3 others, Butler, L., Zannettino, A. & Proud, C., 1 Jan 2020, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2

Xiao, M., Xie, J., Wu, Y., Wang, G., Qi, X., Liu, Z., Wang, Y., Wang, X., Hoque, A., Oakhill, J., Proud, C. & Li, J., 13 Feb 2020, In : Cell Communication and Signaling. 18, 1, 25.

Research output: Contribution to journalArticle

The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation

Galeano Niño, J. L., Tay, S. S., Tearle, J. L. E., Xie, J., Govendir, M. A., Kempe, D., Mazalo, J., Drew, A. P., Colakoglu, F., Kummerfeld, S. K., Proud, C. & Biro, M., 5 Mar 2020, In : Journal of cell science. 133, 5

Research output: Contribution to journalArticle

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress

Xie, J., Van Damme, P., Fang, D. & Proud, C., 3 May 2019, In : Journal of Biological Chemistry. 294, 18, p. 7169-7176 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

Jin, X., Merrett, J., Tong, S., Flower, B., Xie, J., Yu, R., Tian, S., Gao, L., Zhao, J., Wang, X., Jiang, T. & Proud, C., 15 Jan 2019, In : European Journal of Medicinal Chemistry. 162, p. 735-751 17 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Prizes