• 489 Citations
  • 10 h-Index
20112020

Research output per year

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Personal profile

Public Profile

I am the current recipient of the Veronika Sacco Clinical Cancer Research Fellowship in the Myeloma Research Laboratory, Adelaide Medical School, University of Adelaide based in the Cancer Theme at the South Australian Health and Medical Research Institute (SAHMRI).

I completed my PhD through the University of Adelaide in December 2011, with a thesis entitled “An Investigation of mutant p53 function”. In 2012, I began work as a post-doctoral researcher in the Myeloma Research Laboratory where my research interests have centred on the role of the bone marrow microenvironment in the development and progression of Multiple Myeloma.

 

Myeloma is a haematological malignancy that is characterised by the clonal proliferation of plasma cells within the bone marrow. Myeloma is the second most common blood cancer, and is responsible for approximately 80,000 deaths worldwide each year. Although significant advances have been made in the treatment of myeloma in recent years, almost all patients will eventually relapse. My current research interests revolve around investigating the role of the bone marrow microenvironment in the development and progression of myeloma.

Myeloma develops almost exclusively within the bone marrow of patients, wherein myeloma plasma cells colonise discrete niches adjacent to bone and interact with cells of the bone marrow stroma. Stromal cells of the bone marrow niche have been well documented to support the pathogenesis of both primary and metastatic tumours, including myeloma. However, the identity of the cells within the bone marrow microenvironment that are essential for MM development remain to be determined. My primary research interest focuses on identifying a role for bone resident macrophages in mediating myeloma development with the aim of developing novel therapeutic strategies to target the bone microenvironment to limit disease progression. 

Current Projects include:

  • Investigation of the role of the bone marrow microenvironment in the development of myeloma
  • Identification of bone resident macrophage populations involved in mediating myeloma development

 

Education/Academic qualification

PhD, University of Adelaide

20082011

Bachelor of Science (Honours), University of Adelaide

2007

Bachelor's Degree, University of Adelaide

20042006

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Research Output

  • 489 Citations
  • 10 h-Index
  • 12 Article
  • 1 Review article

Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma

Cheong, C. M., Mrozik, K. M., Hewett, D., Bell, E., Panagopoulos, V., Noll, J., Licht, J. D., Gronthos, S., Zannettino, A. & Vandyke, K., 10 Apr 2020, In : Cancer Letters. 475, p. 99-108 10 p.

Research output: Contribution to journalArticle

Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo

Opperman, K. S., Vandyke, K., Clark, K. C., Coulter, E. A., Hewett, D. R., Mrozik, K. M., Schwarz, N., Evdokiou, A., Croucher, P. I., Psaltis, P., Noll, J. E. & Zannettino, A., 1 Aug 2019, In : Neoplasia (United States). 21, 8, p. 777-787 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment

Hewett, D. R., Vandyke, K., Lawrence, D. M., Friend, N., Noll, J. E., Geoghegan, J. M., Croucher, P. I. & Zannettino, A., 1 Dec 2017, In : Neoplasia (United States). 19, 12, p. 972-981 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
12 Citations (Scopus)

Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells

Noll, J. E., Williams, S. A., Tong, C. M., Wang, H., Quach, J. M., Purton, L. E., Pilkington, K., To, L. B., Evdokiou, A., Grontho, S. & Zannettino, A. C. W., 1 Jan 2014, In : Haematologica. 99, 1, p. 163-171 9 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)