• 2849 Citations
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1985 …2019
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Research Output 1985 2019

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Article
2018
3 Citations (Scopus)

Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction

Grundy, L., Harrington, A. M., Castro, J., Garcia-Caraballo, S., Deiteren, A., Maddern, J., Rychkov, G. Y., Ge, P., Peters, S., Feil, R., Miller, P., Ghetti, A., Hannig, G., Kurtz, C. B., Silos-Santiago, I. & Brierley, S. M., 4 Oct 2018, In : JCI Insight. 3, 19

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

Castro, J., Grundy, L., Deiteren, A., Harrington, A., O'Donnell, T., Maddern, J., Moore, J., Garcia-Caraballo, S., Rychkov, G., Yu, R., Kaas, Q., Craik, D. J., Adams, D. J. & Brierley, S., 1 Jun 2018, In : British Journal of Pharmacology. 175, 12, p. 2384-2398 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

NaV1.1 inhibition can reduce visceral hypersensitivity

Salvatierra, J., Castro, J., Erickson, A., Li, Q., Braz, J., Gilchrist, J., Grundy, L., Rychkov, G., Deiteren, A., Rais, R., King, G. F., Slusher, B. S., Basbaum, A., Pasricha, P. J., Brierley, S. & Bosmans, F., 7 Jun 2018, In : JCI insight. 3, 11

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes

Kheradpezhouh, E., Zhou, F. H., Barritt, G. J. & Rychkov, G., 10 Sep 2018, In : Biochemical and Biophysical Research Communications. 503, 3, p. 1891-1896 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension

Grundy, L., Erickson, A., Caldwell, A., Garcia-Caraballo, S., Rychkov, G., Harrington, A. & Brierley, S., 1 Jan 2018, In : Pain. 159, 12, p. 2573-2584 12 p.

Research output: Contribution to journalArticle

2017
23 Citations (Scopus)

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Inserra, M. C., Israel, M. R., Caldwell, A., Castro, J., Deuis, J. R., Harrington, A. M., Keramidas, A., Garcia-Caraballo, S., Maddern, J., Erickson, A., Grundy, L., Rychkov, G. Y., Zimmermann, K., Lewis, R. J., Brierley, S. M. & Vetter, I., 22 Feb 2017, In : Scientific Reports. 7, 42810.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH

Gavriliouk, D., Scrimgeour, N. R., Grigoryev, S., Ma, L., Zhou, F. H., Barritt, G. J. & Rychkov, G., 1 Dec 2017, In : Scientific Reports. 7, 1, 9829.

Research output: Contribution to journalArticle

2016
27 Citations (Scopus)

Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

Kheradpezhouh, E., Barritt, G. J. & Rychkov, G. Y., 1 Apr 2016, In : Redox Biology. 7, p. 1-7 7 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

Osteen, J. D., Herzig, V., Gilchrist, J., Emrick, J. J., Zhang, C., Wang, X., Castro, J., Garcia-Caraballo, S., Grundy, L., Rychkov, G. Y., Weyer, A. D., Dekan, Z., Undheim, E. A. B., Alewood, P., Stucky, C. L., Brierley, S. M., Basbaum, A. I., Bosmans, F., King, G. F. & Julius, D., 6 Jun 2016, In : Nature. 534, 7608, p. 494-499 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide

Zhang, W., Garg, S., Eldi, P., Zhou, F. H. H., Johnson, I. R. D., Brooks, D. A., Lam, F., Rychkov, G., Hayball, J. & Albrecht, H., 20 Nov 2016, In : International Journal of Pharmaceutics. 513, 1-2, p. 270-279 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca2 + signalling in steatotic hepatocytes

Ali, E. S., Hua, J., Wilson, C. H., Tallis, G. A., Zhou, F. H., Rychkov, G. Y. & Barritt, G. J., 1 Sep 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 9, p. 2135-2146 12 p.

Research output: Contribution to journalArticle

2015
21 Citations (Scopus)

Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel

Karttunen, S., Duffield, M., Scrimgeour, N. R., Squires, L., Lim, W. L., Dallas, M. L., Scragg, J. L., Chicher, J., Dave, K. A., Whitelaw, M. L., Peers, C., Gorman, J. J., Gleadle, J. M., Rychkov, G. Y. & Peet, D. J., 1 Jan 2015, In : Journal of Cell Science. 128, 2, p. 225-231 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism

Wilson, C. H., Ali, E. S., Scrimgeour, N., Martin, A. M., Hua, J., Tallis, G. A., Rychkov, G. Y. & Barritt, G. J., 1 Mar 2015, In : Biochemical Journal. 466, p. 379-390 12 p.

Research output: Contribution to journalArticle

2014
19 Citations (Scopus)

Nedd4-2 (NEDD4L) controls intracellular Na+ -mediated activity of voltage-gated sodium channels in primary cortical neurons

Ekberg, J. A., Boase, N. A., Rychkov, G., Manning, J., Poronnik, P. & Kumar, S., 1 Jan 2014, In : Biochemical Journal. 457, 1, p. 27-31 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Neurogenic potential of dental pulp stem cells isolated from murine incisors

Ellis, K. M., O'Carroll, D. C., Lewis, M. D., Rychkov, G. Y. & Koblar, S. A., 27 Feb 2014, In : Stem Cell Research and Therapy. 5, 1, 30.

Research output: Contribution to journalArticle

48 Citations (Scopus)

TRPM2 channels mediate acetaminophen-induced liver damage

Kheradpezhouh, E., Ma, L., Morphett, A., Barritt, G. J. & Rychkov, G. Y., 25 Feb 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3176-3181 6 p.

Research output: Contribution to journalArticle

2013
43 Citations (Scopus)

Mutations of the ca2+-sensing stromal interaction molecule stim1 regulate ca2+ influx by altered oligomerization of stim1 and by destabilization of the ca2+ channel orai1

Kilch, T., Alansary, D., Peglow, M., Dorr, K., Rychkov, G., Rieger, H., Peinelt, C. & Niemeyer, B. A., 18 Jan 2013, In : Journal of Biological Chemistry. 288, 3, p. 1653-1664 12 p.

Research output: Contribution to journalArticle

2012
25 Citations (Scopus)

Glu 106in the Orai1 pore contributes to fast Ca 2+ -dependent inactivation and pH dependence of Ca 2+ release-activated Ca 2+ (CRAC) current

Scrimgeour, N. R., Wilson, D. P. & Rychkov, G. Y., 15 Jan 2012, In : Biochemical Journal. 441, 2, p. 743-753 11 p.

Research output: Contribution to journalArticle

2011

Expression and function of TRP channels in liver cells

Rychkov, G. Y. & Barritt, G. J., 1 Jan 2011, In : Advances in Experimental Medicine and Biology. 704, p. 1-20 20 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location

Ma, L., Rychkov, G. Y., Bykova, E. A., Zheng, J. & Bretag, A. H., 1 Jun 2011, In : Biochemical Journal. 436, 2, p. 415-428 14 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

Boase, N. A., Rychkov, G. Y., Townley, S. L., Dinudom, A., Candi, E., Voss, A. K., Tsoutsman, T., Semsarian, C., Melino, G., Koentgen, F., Cook, D. I. & Kumar, S., 27 Apr 2011, In : Nature communications. 2, 1, 287.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The predominant role of IP 3 type 1 receptors in activation of store-operated Ca 2+ entry in liver cells

Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G. J. & Rychkov, G. Y., 1 Mar 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 3, p. 745-751 7 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2010
20 Citations (Scopus)

Inter-subunit communication and fast gate integrity are important for common gating in hClC-1

Cederholm, J. M., Rychkov, G. Y., Bagley, C. J. & Bretag, A. H., Jul 2010, In : International Journal of Biochemistry and Cell Biology. 42, 7, p. 1182-1188 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca2+ current in liver cells

To, M. S., Aromataris, E. C., Castro, J., Roberts, M. L., Barritt, G. J. & Rychkov, G. Y., 15 Mar 2010, In : Archives of Biochemistry and Biophysics. 495, 2, p. 152-158 7 p.

Research output: Contribution to journalArticle

2009
20 Citations (Scopus)
5 Citations (Scopus)

Functional study of cytoplasmic loops of human skeletal muscle chloride channel, hClC-1

Ma, L., Rychkov, G. Y. & Bretag, A. H., 1 Jun 2009, In : International Journal of Biochemistry and Cell Biology. 41, 6, p. 1402-1409 8 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

Scrimgeour, N., Litjens, T., Ma, L., Barritt, G. J. & Rychkov, G. Y., 15 Jun 2009, In : Journal of Physiology. 587, 12, p. 2903-2918 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The contribution of voltage-gated Ca2+ currents to K+ channel activation during ovine adrenal chromaffin cell development

Keating, D. J., Rychkov, G. Y. & Roberts, M. L., Jun 2009, In : International Journal of Developmental Neuroscience. 27, 4, p. 357-363 7 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli

Brierley, S. M., Hughes, P. A., Page, A. J., Kwan, K. Y., Martin, C. M., O'Donnell, T. A., Cooper, N. J., Harrington, A. M., Adam, B., Liebregts, T., Holtmann, G., Corey, D. P., Rychkov, G. Y. & Blackshaw, L. A., 1 Jan 2009, In : Gastroenterology. 137, 6

Research output: Contribution to journalArticle

2008
352 Citations (Scopus)
5 Citations (Scopus)

Analysis of carboxyl tail function in the skeletal muscle Cl- channel hClC-1

Ma, L., Rychkov, G. Y., Hughes, B. P. & Bretag, A. H., 1 Jul 2008, In : Biochemical Journal. 413, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2007
30 Citations (Scopus)

Phospholipase C-γ1 is required for the activation of store-operated Ca2+ channels in liver cells

Litjens, T., Nguyen, T., Castro, J., Aromataris, E. C., Jones, L., Barritt, G. J. & Rychkov, G. Y., 15 Jul 2007, In : Biochemical Journal. 405, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

2006
16 Citations (Scopus)

ClC-1 chloride channel: Matching its properties to a role in skeletal muscle

Aromataris, E. C. & Rychkov, G. Y., 1 Nov 2006, In : Clinical and Experimental Pharmacology and Physiology. 33, 11, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Functional complementation of truncated human skeletal-muscle chloride channel (hClC-1) using carboxyl tail fragments

Wu, W., Rychkov, G. Y., Hughes, B. P. & Bretag, A. H., 1 Apr 2006, In : Biochemical Journal. 395, 1, p. 89-97 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Glucagon activates Ca2+ and Cl- channels in rat hepatocytes

Aromataris, E. C., Roberts, M. L., Barritt, G. J. & Rychkov, G. Y., 15 Jun 2006, In : Journal of Physiology. 573, 3, p. 611-625 15 p.

Research output: Contribution to journalArticle

2005
22 Citations (Scopus)

Arachidonic acid inhibits the store-operated Ca2+ current in rat liver cells

Rychkov, G. Y., Litjens, T., Roberts, M. L. & Barritt, G. J., 15 Jan 2005, In : Biochemical Journal. 385, 2, p. 551-556 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

ATP and vasopressin activate a single type of store-operated Ca2+ channel, identified by patch-clamp recording, in rat hepatocytes

Rychkov, G. Y., Litjens, T., Roberts, M. L. & Barritt, G. J., 1 Jan 2005, In : Cell Calcium. 37, 2, p. 183-191 9 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

Bennetts, B., Rychkov, G. Y., Ng, H. L., Morton, C. J., Stapleton, D., Parker, M. W. & Cromer, B. A., 16 Sep 2005, In : Journal of Biological Chemistry. 280, 37, p. 32452-32458 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Oxygen-sensing pathway for SK channels in the ovine adrenal medulla

Keating, D. J., Rychkov, G. Y., Giacomin, P. & Roberts, M. L., Oct 2005, In : Clinical and Experimental Pharmacology and Physiology. 32, 10, p. 882-887 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Zinc inhibits human ClC-1 muscle chloride channel by interacting with its common gating mechanism

Duffield, M. D., Rychkov, G. Y., Bretag, A. H. & Roberts, M. L., 1 Oct 2005, In : Journal of Physiology. 568, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

2004
25 Citations (Scopus)

Characterization of three myotonia-associated mutations of the CLCN1 chloride channel gene via heterologous expression.

Simpson, B. J., Height, T. A., Rychkov, G. Y., Nowak, K. J., Laing, N. G., Hughes, B. P. & Bretag, A. H., 1 Jan 2004, In : Human Mutation. 24, 2, 1 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Fast Ca2+-dependent inactivation of the store-operated Ca2+ current (ISOC) in liver cells: A role for calmodulin

Litjens, T., Harland, M. L., Roberts, M. L., Barritt, G. J. & Rychkov, G. Y., 1 Jul 2004, In : Journal of Physiology. 558, 1, p. 85-97 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels

Keating, D. J., Rychkov, G. Y., Adams, M. B., Holgert, H., McMillen, I. C. & Roberts, M. L., 1 Mar 2004, In : Journal of Physiology. 555, 2, p. 489-502 14 p.

Research output: Contribution to journalArticle

2003
85 Citations (Scopus)

Involvement of helices at the dimer interface in ClC-1 common gating

Duffield, M., Rychkov, G., Bretag, A. & Roberts, M., 1 Feb 2003, In : Journal of General Physiology. 121, 2, p. 149-161 13 p.

Research output: Contribution to journalArticle

2001
158 Citations (Scopus)
26 Citations (Scopus)

Fast and slow gating of CLC-1: Differential effects of 2-(4-chlorophenoxy) propionic acid and dominant negative mutations

Aromataris, E. C., Rychkov, G. Y., Bennetts, B., Hughes, B. P., Bretag, A. H. & Roberts, M. L., 1 Jan 2001, In : Molecular Pharmacology. 60, 1, p. 200-208 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC-1: Effects on permeation and gating

Rychkov, G. Y., Pusch, M., Roberts, M. L. & Bretag, A. H., 1 Feb 2001, In : Journal of Physiology. 530, 3, p. 379-393 15 p.

Research output: Contribution to journalArticle