Georgina Eden

  • 50 Citations
  • 5 h-Index
20162020

Research output per year

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Personal profile

Public Profile

Georgina completed her Honours at The University of Adelaide working on developing novel therapies for the adverse side effects of chemotherapy on the gastrointestinal tract. She then worked at the Children’s Cancer Institute in Sydney for 4 years where she assisted in discovering new therapeutic approaches for the treatment of Neuroblastoma (most common extracranial solid tumour in children). During her time at the Children’s Cancer Institute she was involved in the Zero Childhood Cancer national clinical trial. This trial aims to develop personalised cancer treatment strategies for children, throughout Australia, with high-risk or relapsed cancer.

In mid-2018, Georgina returned to Adelaide to work as an EMBL Australia Laboratory Manager and Research Officer in David Lynn’s Computational and Systems Biology Program, part of the Precision Medicine Theme at SAHMRI. She is assisting in projects investigating the interplay between the microbiota and the immune system.

 

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Research Output

  • 50 Citations
  • 5 h-Index
  • 7 Article

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

Kamili, A., Gifford, A. J., Li, N., Mayoh, C., Chow, S. O., Failes, T. W., Eden, G. L., Cadiz, R., Xie, J., Lukeis, R. E., Norris, M. D., Haber, M., McCowage, G. B., Arndt, G. M., Trahair, T. N. & Fletcher, J. I., 3 Mar 2020, In : British Journal of Cancer. 122, 5, p. 680-691 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition

Khan, A., Valli, E., Lam, H., Scott, D. A., Murray, J., Hanssen, K. M., Eden, G., Gamble, L. D., Pandher, R., Flemming, C. L., Allan, S., Osterman, A. L., Haber, M., Norris, M. D., Fletcher, J. I. & Yu, D. M. T., 23 Apr 2020, In : Oncogene. 39, 17, p. 3555-3570 16 p.

Research output: Contribution to journalArticle

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

Gamble, L. D., Purgato, S., Murray, J., Xiao, L., Yu, D. M. T., Hanssen, K. M., Giorgi, F. M., Carter, D. R., Gifford, A. J., Valli, E., Milazzo, G., Kamili, A., Mayoh, C., Liu, B., Eden, G., Sarraf, S., Allan, S., Giacomo, S. D., Flemming, C. L., Russell, A. J. & 13 others, Cheung, B. B., Oberthuer, A., London, W. B., Fischer, M., Trahair, T. N., Fletcher, J. I., Marshall, G. M., Ziegler, D. S., Hogarty, M. D., Burns, M. R., Perini, G., Norris, M. D. & Haber, M., 30 Jan 2019, In : Science Translational Medicine. 11, 477, aau1099.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Macrophage-derived IL1B and TNFa regulate arginine metabolism in neuroblastoma

Fultang, L., Gamble, L. D., Gneo, L., Berry, A. M., Egan, S. A., De Bie, F., Yogev, O., Eden, G., Booth, S., Brownhill, S., Vardon, A., McConville, C. M., Cheng, P. N., Norris, M. D., Etchevers, H. C., Murray, J., Ziegler, D. S., Chesler, L., Schmidt, R., Burchill, S. A. & 3 others, Haber, M., De Santo, C. & Mussai, F., 1 Feb 2019, In : Cancer Research. 79, 3, p. 611-624 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo

Murray, J., Valli, E., Yu, D. M. T., Truong, A. M., Gifford, A. J., Eden, G., Gamble, L. D., Hanssen, K. M., Flemming, C. L., Tan, A., Tivnan, A., Allan, S., Saletta, F., Cheung, L., Ruhle, M., Schuetz, J. D., Henderson, M. J., Byrne, J. A., Norris, M. D., Haber, M. & 1 others, Fletcher, J. I., 1 Sep 2017, In : European Journal of Cancer. 83, p. 132-141 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)