Fatwa Adikusuma

Dr

  • 123 Citations
  • 5 h-Index
20172019

Research output per year

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Personal profile

Public Profile

Dr Adikusuma is a research fellow in Genome Editing Laboratory led by Prof Paul Thomas. He completed his PhD at the University of Adelaide under Prof Thomas supervision. He is the recipient of a fellowship from CSIRO Synthetic Biology Future Science Platform. Dr Adikusuma discovered the strategies to eliminate an entire chromosome using CRISPR genome editing. Also, his landmark finding that CRISPR-Cas9 cleavage often induces large deletions (Adikusuma et al Nature 2018) cautions the biomedical community about unintended and hitherto unrecognised editing outcomes that could occur when performing germline CRISPR genome editing therapy. Together with his students and Prof Thomas, he is now developing a highly efficient strategy of using CRISPR genome editing for therapeutic of Duchenne Muscular Dystrophy that could lead to effective clinical genome editing therapy using CRISPR system.

Education/Academic qualification

PhD, University of Adelaide

Nov 2011Oct 2017

External positions

Postdoctoral scientist, Adelaide Medical School

Dec 2017 → …

University of Adelaide

Keywords

  • Gene editing
  • Genome engineering
  • DMD
  • CRISPR
  • Therapy

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Research Output

  • 123 Citations
  • 5 h-Index
  • 6 Article
  • 1 Letter

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

Prowse, T. A., Adikusuma, F., Cassey, P., Thomas, P. & Ross, J. V., 1 Feb 2019, In : eLife. 8, e41873.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Expanding the RNA-Guided Endonuclease Toolkit for Mouse Genome Editing

Robertson, L., Pederick, D., Piltz, S., White, M., Nieto, A., Ahladas, M., Adikusuma, F. & Thomas, P. Q., Dec 2018, In : The CRISPR journal. 1, p. 431-439 9 p.

Research output: Contribution to journalArticle

Large deletions induced by Cas9 cleavage

Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T. & Thomas, P., 9 Aug 2018, In : Nature. 560, 7717, p. E8-E9

Research output: Contribution to journalArticle

38 Citations (Scopus)

Functional equivalence of the SOX2 and SOX3 transcription factors in the developing mouse brain and testes

Adikusuma, F., Pederick, D., McAninch, D., Hughes, J. & Thomas, P., 1 Jul 2017, In : Genetics. 206, 3, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

Adikusuma, F., Williams, N., Grutzner, F., Hughes, J. & Thomas, P., 2 Aug 2017, In : Molecular Therapy. 25, 8, p. 1736-1738 3 p.

Research output: Contribution to journalLetter

18 Citations (Scopus)