Deborah White

Professor

  • Director, Cancer Program, Cancer
  • 4031 Citations
  • 26 h-Index
1987 …2019
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Research Output 1987 2019

2019

Gene expression signature that predicts early molecular response failure in chronic-phase CML patients on frontline imatinib

Kok, C., Yeung, D., Lu, L., Watkins, D. B., Gray, T., Dang, Y., Saunders, V., Reynolds, J., White, D. & Hughes, T., 28 May 2019, In : Blood Advances. 3, 10, p. 1610-1621 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lenalidomide maintenance treatment after imatinib discontinuation: results of a phase 1 clinical trial in chronic myeloid leukaemia

Ross, D. M., Pagani, I., Irani, Y., Clarson, J., Gray, T., Dang, Y., McLean, J., Saunders, V., Carne, L., Reynolds, J., Ritchie, D. S., White, D., Branford, S., Hughes, T. & Yong, A., 1 Aug 2019, In : British Journal of Haematology. 186, 3, p. e56-e60

Research output: Contribution to journalLetter

7 Citations (Scopus)

BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia

Pagani, I. S., Dang, P., Kommers, I. O., Goyne, J. M., Nicola, M., Saunders, V. A., Braley, J., White, D. L., Yeung, D. T., Branford, S., Hughes, T. P. & Ross, D. M., 30 Nov 2018, In : Haematologica. 103, 12, p. 2026-2032 7 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten

Nair, S. S., Luu, P. L., Qu, W., Maddugoda, M., Huschtscha, L., Reddel, R., Chenevix-Trench, G., Toso, M., Kench, J. G., Horvath, L. G., Hayes, V. M., Stricker, P. D., Hughes, T. P., White, D. L., Rasko, J. E. J., Wong, J. J. L. & Clark, S. J., 28 May 2018, In : Epigenetics and Chromatin. 11, 1, 24.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease

Branford, S., Wang, P., Yeung, D., Thomson, D., Purins, A., Wadham, C., Shahrin, N. H., Marum, J. E., Nataren, N., Parker, W. T., Geoghegan, J., Feng, J., Shanmuganathan, N., Mueller, M. C., Dietz, C., Stangl, D., Donaldson, Z., Altamura, H., Georgievski, J., Braley, J. & 13 othersBrown, A., Hahn, C., Walker, I., Kim, S. H., Choi, S. Y., Park, S. H., Kim, D. W., White, D., Yong, A., Ross, D. M., Scott, H. S., Schreiber, A. W. & Hughes, T., 30 Aug 2018, In : Blood. 132, 9, p. 948-961 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Long-term treatment-free remission of chronic myeloid leukemia with falling levels of residual leukemic cells

on behalf of the Australasian Leukaemia and Lymphoma Group (ALLG), 1 Dec 2018, In : Leukemia. 32, 12, p. 2572-2579 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant BCR-ABL1+ cell lines

Lu, L., Kok, C. H., Saunders, V. A., Wang, J., McLean, J. A., Hughes, T. & White, D. L., 1 Oct 2018, In : Oncotarget. 9, 78, p. 34735-34747 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression

McClure, B., Heatley, S., Kok, C., Sadras, T., An, J., Hughes, T., Lock, R. B., Yeung, D., Sutton, R. & White, D., 1 Apr 2018, In : British Journal of Cancer. 118, 7, p. 1000-1004 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro

Eadie, L., Saunders, V., Branford, S., White, D. & Hughes, T., 1 Jan 2018, In : Oncotarget. 9, 17, p. 13423-13437 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH

Sadras, T., Heatley, S. L., Kok, C. H., McClure, B. J., Yeung, D., Hughes, T. P., Sutton, R., Ziegler, D. S. & White, D. L., 1 Oct 2017, In : Cancer Genetics. 216-217, p. 86-90 5 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

CML patients with deep molecular responses to TKI have restored immune effectors and decreased PD-1 and immune suppressors

Hughes, A., Clarson, J., Tang, C., Vidovic, L., White, D. L., Hughes, T. P. & Yong, A. S. M., 2 Mar 2017, In : Blood. 129, 9, p. 1166-1176 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients

Barratt, D. T., Cox, H. K., Menelaou, A., Yeung, D., White, D., Hughes, T. & Somogyi, A. A., 1 Aug 2017, In : Clinical Pharmacokinetics. 56, 8, p. 977-985 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions

Sadras, T., Heatley, S. L., Kok, C. H., Dang, Y., Galbraith, K. M., McClure, B. J., Muskovic, W., Venn, N. C., Moore, S., Osborn, M., Revesz, T., Moore, A. S., Hughes, T. P., Yeung, D., Sutton, R. & White, D. L., 30 Aug 2017, In : Cancer Letters.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment

Heatley, S., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, Y., McClure, B., Venn, N. C., Moore, S., Suttle, J. M., Law, T., Ng, A., Muskovic, W., Norris, M., Revesz, T., Osborn, M., Moore, S., Suppiah, R., Fraser, C., Alvaro, F. & 7 othersHughes, T., Mullighan, C. G., Marshall, G. M., Dalla Pozza, L., Yeung, D., Sutton, R. & White, D., Dec 2017, In : Haematologica. p. e490-e493

Research output: Contribution to journalLetter

2 Citations (Scopus)

Modelling predictors of molecular response to frontline imatinib for patients with chronic myeloid leukaemia

Banjar, H., Ranasinghe, D., Brown, F., Adelson, D., Kroger, T., Gray, T., White, D., Hughes, T. & Chaudhri, N., 1 Jan 2017, In : PloS one. 12, 1, e0168947.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Reduced CD62L expression on T cells and increased soluble CD62L levels predict molecular response to tyrosine kinase inhibitor therapy in early chronic-phase chronic myelogenous leukemia

Sopper, S., Mustjoki, S., White, D., Hughes, T., Valent, P., Burchert, A., Gjertsen, B. T., Gastl, G., Baldauf, M., Trajanoski, Z., Giles, F., Hochhaus, A., Ernst, T., Schenk, T., Janssen, J. J. W. M., Ossenkoppele, G. J., Porkka, K. & Wolf, D., 10 Jan 2017, In : Journal of Clinical Oncology. 35, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2016
18 Citations (Scopus)
9 Citations (Scopus)

Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant

Richmond, J., Robbins, A., Evans, K., Beck, D., Kurmasheva, R. T., Billups, C. A., Carol, H., Heatley, S., Sutton, R., Marshall, G. M., White, D., Pimanda, J., Houghton, P. J., Smith, M. A. & Lock, R. B., 1 Aug 2016, In : Cancer Research. 76, 15, p. 4579-4591 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

BCR-ABL1 expression, RT-qPCR and treatment decisions in chronic myeloid leukaemia

Latham, S., Bartley, P. A., Budgen, B., Ross, D. M., Hughes, E., Branford, S., White, D., Hughes, T. P. & Morley, A. A., 1 Sep 2016, In : Journal of Clinical Pathology. 69, 9, p. 817-821 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Characterization of leukemias with ETV6-ABL1 fusion

Zaliova, M., Moorman, A. V., Cazzaniga, G., Stanulla, M., Harvey, R. C., Roberts, K. G., Heatley, S. L., Loh, M. L., Konopleva, M., Chen, I. M., Zimmermannova, O., Schwab, C., Smith, O., Mozziconacci, M. J., Chabannon, C., Kim, M., Frederik Falkenburg, J. H., Norton, A., Marshall, K., Haas, O. A. & 9 othersStarkova, J., Stuchly, J., Hunger, S. P., White, D., Mullighan, C. G., Willman, C. L., Stary, J., Trka, J. & Zuna, J., 1 Jan 2016, In : Haematologica. 101, 9, p. 1082-1093 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

COBL is a novel hotspot for IKZF1 deletions in childhood acute lymphoblastic leukemia

Lopes, B. A., Meyer, C., Barbosa, T. C., Stadt, U. Z., Horstmann, M., Venn, N. C., Heatley, S., White, D. L., Sutton, R., Pombo-de-Oliveira, M. S., Marschalek, R. & Emerenciano, M., 1 Aug 2016, In : Oncotarget. 7, 33, p. 53064-53073 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia

Dolai, S., Sia, K. C. S., Robbins, A. K., Zhong, L., Heatley, S. L., Vincent, T. L., Hochgräfe, F., Sutton, R., Kurmasheva, R. T., Revesz, T., White, D. L., Houghton, P. J., Smith, M. A., Teachey, D. T., Daly, R. J., Raftery, M. J. & Lock, R. B., 1 May 2016, In : Cancer Research. 76, 9, p. 2766-2777 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy

Nievergall, E., Reynolds, J., Kok, C. H., Watkins, D. B., Biondo, M., Busfield, S. J., Vairo, G., Fuller, K., Erber, W. N., Sadras, T., Grose, R., Yeung, D. T., Lopez, A. F., Hiwase, D. K., Hughes, T. P. & White, D. L., 1 Jun 2016, In : Leukemia. 30, 6, p. 1263-1272 10 p.

Research output: Contribution to journalArticle

The role of Wnt/β-Catenin signaling in normal and malignant hematopoiesis

Sadras, T., D'Andrea, R. & White, D., 2016, In : Journal of blood research & hematologic diseases. 1, p. 1 9 p., 1000103.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Xenograft-directed personalized therapy for a patient with post-transplant relapse of ALL

Trahair, T. N., Lock, R. B., Sutton, R., Sia, K. C. S., Evans, K., Richmond, J., Law, T., Venn, N. C., Irving, J. A., Moore, S., Nievergall, E., Dang, P., Heatley, S. L., White, D. L. & Revesz, T., 1 Sep 2016, In : Bone Marrow Transplantation. 51, 9, p. 1279-1282 4 p.

Research output: Contribution to journalLetter

2015
14 Citations (Scopus)

A DNA real-time quantitative PCR method suitable for routine monitoring of low levels of minimal residual disease in chronic myeloid leukemia

Bartley, P. A., Latham, S., Budgen, B., Ross, D. M., Hughes, E., Branford, S., White, D., Hughes, T. P. & Morley, A. A., 1 Jan 2015, In : Journal of Molecular Diagnostics. 17, 2, p. 185-192 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

KIR2DL5B genotype predicts outcomes in CML patients treated with response-directed sequential imatinib/nilotinib strategy

Yeung, D. T., Tang, C., Vidovic, L., White, D. L., Branford, S., Hughes, T. P. & Yong, A. S., 17 Dec 2015, In : Blood. 126, 25, p. 2720-2723 4 p.

Research output: Contribution to journalArticle

Living with CML: Is death no longer the end (point)?

White, D. & Hughes, T., 2 Jul 2015, In : Blood. 126, 1, p. 2-4 3 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

OCT1 and imatinib transport in CML: Is it clinically relevant?

Watkins, D. B., Hughes, T. & White, D., 1 Oct 2015, In : Leukemia. 29, 10, p. 1960-1969 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Ponatinib is not transported by ABCB1, ABCG2 or OCT-1 in CML cells

Lu, L., Saunders, V. A., Leclercq, T. M., Hughes, T. P. & White, D. L., 7 Aug 2015, In : Leukemia. 29, 8, p. 1792-1794 3 p.

Research output: Contribution to journalLetter

14 Citations (Scopus)

Relapse of BCR-ABL1-like ALL mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment

Yeung, D. T., Moulton, D. J., Heatley, S. L., Nievergall, E., Dang, P., Braley, J., Branford, S., Moore, S., Mullighan, C. G., Hughes, T. P. & White, D. L., 10 Jan 2015, In : Leukemia. 29, 1, p. 230-232 3 p.

Research output: Contribution to journalLetter

20 Citations (Scopus)

Sustained inhibition of STAT5, but not JAK2, is essential for TKI-induced cell death in chronic myeloid leukemia

Schafranek, L., Nievergall, E., Powell, J. A., Hiwase, D. K., Leclercq, T., Hughes, T. P. & White, D. L., 1 Jan 2015, In : Leukemia. 29, 1, p. 76-85 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

TIDEL-Ii: First-line use of imatinib in CML with early switch to nilotinib for failure to achieve time-dependent molecular targets

Yeung, D. T., Osborn, M. P., White, D. L., Branford, S., Braley, J., Herschtal, A., Kornhauser, M., Issa, S., Hiwase, D. K., Hertzberg, M., Schwarer, A. P., Filshie, R., Arthur, C. K., Kwan, Y. L., Trotman, J., Forsyth, C. J., Taper, J., Ross, D. M., Beresford, J., Tam, C. & 3 othersMills, A. K., Grigg, A. P. & Hughes, T. P., 5 Feb 2015, In : Blood. 125, 6, p. 915-923 9 p.

Research output: Contribution to journalArticle

2014
5 Citations (Scopus)

Elevated PTPN2 expression is associated with inferior molecular response in de-novo chronic myeloid leukaemia patients

Kok, C. H., Leclercq, T., Watkins, D. B., Saunders, V., Wang, J., Hughes, T. P. & White, D. L., 1 Jan 2014, In : Leukemia. 28, 3, p. 702-705 4 p.

Research output: Contribution to journalLetter

36 Citations (Scopus)
49 Citations (Scopus)

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells

Nievergall, E., Ramshaw, H. S., Yong, A. S. M., Biondo, M., Busfield, S. J., Vairo, G., Lopez, A. F., Hughes, T. P., White, D. L. & Hiwase, D. K., 20 Feb 2014, In : Blood. 123, 8, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

560 Citations (Scopus)

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

Roberts, K. G., Li, Y., Payne-Turner, D., Harvey, R. C., Yang, Y. L., Pei, D., McCastlain, K., Ding, L., Lu, C., Song, G., Ma, J., Becksfort, J., Rusch, M., Chen, S. C., Easton, J., Cheng, J., Boggs, K., Santiago-Morales, N., Iacobucci, I., Fulton, R. S. & 54 othersWen, J., Valentine, M., Cheng, C., Paugh, S. W., Devidas, M., Chen, I. M., Reshmi, S., Smith, A., Hedlund, E., Gupta, P., Nagahawatte, P., Wu, G., Chen, X., Yergeau, D., Vadodaria, B., Mulder, H., Winick, N. J., Larsen, E. C., Carroll, W. L., Heerema, N. A., Carroll, A. J., Grayson, G., Tasian, S. K., Moore, A. S., Keller, F., Frei-Jones, M., Whitlock, J. A., Raetz, E. A., White, D. L., Hughes, T. P., Guidry Auvil, J. M., Smith, M. A., Marcucci, G., Bloomfield, C. D., Mrózek, K., Kohlschmidt, J., Stock, W., Kornblau, S. M., Konopleva, M., Paietta, E., Pui, C. H., Jeha, S., Relling, M. V., Evans, W. E., Gerhard, D. S., Gastier-Foster, J. M., Mardis, E., Wilson, R. K., Loh, M. L., Downing, J. R., Hunger, S. P., Willman, C. L., Zhang, J. & Mullighan, C. G., 11 Sep 2014, In : New England Journal of Medicine. 371, 11, p. 1005-1015 11 p.

Research output: Contribution to journalArticle

Validation of Nanostring Microrna Analysis in Leukaemic Blood

Gordon, J., Bailey, C., Ritchie, W., Watkins, D. B., Gray (leclercq), T., White, D., Hughes, T. & Rasko, J. E. J., 2014, In : Pathology.

Research output: Contribution to journalArticle

2013
23 Citations (Scopus)

A common novel splice variant of SLC22A1 (OCT1) is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia

Grinfeld, J., Gerrard, G., Alikian, M., Alonso-Dominguez, J., Ale, S., Valgañon, M., Nteliopoulos, G., White, D., Marin, D., Hedgley, C., O'Brien, S., Clark, R., Goldman, J. M., Milojkovic, D., Apperley, J. F. & Foroni, L., 1 Dec 2013, In : British Journal of Haematology. 163, 5, p. 631-639 9 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy

Angelini, S., Soverini, S., Ravegnini, G., Barnett, M., Turrini, E., Thornquist, M., Pane, F., Hughes, T. P., White, D. L., Radich, J., Kim, D. W., Saglio, G., Cilloni, D., Iacobucci, I., Perini, G., Woodman, R., Cantelli-Forti, G., Baccarani, M., Hrelia, P. & Martinelli, G., 1 Feb 2013, In : Haematologica. 98, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
8 Citations (Scopus)

Dasatinib targets chronic myeloid leukemia-CD34+ progenitors as effectively as it targets mature cells

Hiwase, D. K., Saunders, V. A., Nievergall, E., Ross, D. D., White, D. L. & Hughes, T. P., 6 Jun 2013, In : Haematologica. 98, 6, p. 896-900 5 p.

Research output: Contribution to journalArticle