David Lynn

Professor

  • 4088 Citations
  • 28 h-Index
20022019
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Personal profile

Public Profile

David has an international track record in applying computational and experimental systems biology approaches to investigate the immune system. Following a PhD in computational immunology and a postdoctoral position in population immunogenomics at Trinity College Dublin, he moved to Vancouver (SFU & UBC) where he was the lead computational biologist on a Grand Challenges in Global Health Initiative project investigating how to modulate the innate immune response to several pathogens of major importance to global health. He was also awarded a a Michael Smith Foundation for Health Research postdoctoral fellowship during this time. In 2009, he was appointed as a “Vision” Group Leader in Computational Biology at the Irish agriculture and food research agency (Teagasc), where his group developed computational and experimental approaches (particularly NGS based) to investigate the immune response to several bovine infectious diseases. Within 3 years here, he built up a group of eight people and attracted more than €1.5 million in funding. He also continued to collaborate extensively in the area of human infectious disease. In 2011, he was awarded the Teagasc Excellence in Research Award. In 2014, he fulfilled his wish to return full-time to human translational research and was appointed as EMBL Australia Group Leader in the Infection and Immunity Theme at the South Australian Health and Medical Research (SAHMRI). He also holds a joint faculty appointment as Professor at the School of Medicine, Flinders University. At SAHMRI, David’s group is a multi-disciplinary group that is equally divided between bioinformatics and experimental biology. On the wet-lab side his group employs in vitro and in vivo experimental and clinical models coupled with systems biology approaches to investigate the interplay between the microbiome, vaccines and the immune system. On the bioinformatics side his group leads the development of InnateDB.com, an internationally recognised systems biology platform for innate immunity networks (10,000 users worldwide). David also leads the computational biology aspects of €12 million European Commission funded project called PRIMES, which is investigating how to model and subsequently therapeutically target protein interaction networks in cancer.

Education/Academic qualification

PhD, University College Dublin

20012004

Masters, University of Ottawa

20002001

Bachelor's Degree (Honours), Trinity College Dublin

19962000

External positions

Professor, School of Medicine, Flinders University, Flinders University

1 Jan 2019 → …

Associate Professor, School of Medicine, Flinders University

201431 Dec 2018

Adjunct Lecturer, School of Biochemistry & Immunology, Trinity College Dublin, Ireland.

20122013

Vision Appointment in Computational Biology, Teagasc

20092014

Postdoctoral Research Associate, Simon Fraser University

20072009

Honorary Research Associate, University of British Columbia

20072009

Postdoctoral Fellow, Trinity College Dublin, Ireland.

20042006

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Research Output 2002 2019

Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

del-Toro, N., Duesbury, M., Koch, M., Perfetto, L., Shrivastava, A., Ochoa, D., Wagih, O., Piñero, J., Kotlyar, M., Pastrello, C., Beltrao, P., Furlong, L. I., Jurisica, I., Hermjakob, H., Orchard, S., Porras, P., Khadake, J., Meldal, B., Panni, S., Thorneycroft, D. & 23 othersvan Roey, K., Abbani, S., Salwinski, L., Pellegrini, M., Iannuccelli, M., Licata, L., Cesareni, G., Roechert, B., Bridge, A., Ammari, M. G., McCarthy, F., Broackes-Carter, F., Campbell, N. H., Melidoni, A. N., Rodriguez-Lopez, M., Lovering, R. C., Jagannathan, S., Chen, C., Lynn, D. J., Ricard-Blum, S., Mahadevan, U., Raghunath, A. & authors, IME. C. C., 2019, In : Nature Communications. 10, 1

Research output: Contribution to journalArticle

Analysis and visualization of dynamic networks using the DyNet App for cytoscape

Salamon, J., Goenawan, I. H. & Lynn, D., 31 Aug 2018, In : Current Protocols in Bioinformatics. 30168906.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., Kang, J. H., Haines, J. L., Souzeau, E., Zhou, T., Siggs, O. M., Landers, J., Awadalla, M., Sharma, S., Mills, R. A., Ridge, B., Lynn, D., Casson, R., Graham, S. L., Goldberg, I. & 20 othersWhite, A., Healey, P. R., Grigg, J., Lawlor, M., Mitchell, P., Ruddle, J., Coote, M., Walland, M., Best, S., Vincent, A., Gale, J., RadfordSmith, G., Whiteman, D. C., Montgomery, G. W., Martin, N. G., Mackey, D. A., Wiggs, J. L., MacGregor, S., Craig, J. E. & NEIGHBORHOOD consortium, 15 Feb 2018, In : Scientific Reports. 8, 1, p. 3124

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion

Armstrong, H. K., Gillis, J. L., Johnson, I. R. D., Nassar, Z. D., Moldovan, M., Levrier, C., Sadowski, M. C., Chin, M. Y., Tomlinson Guns, E. S., Tarulli, G., Lynn, D. J., Brooks, D. A., Selth, L. A., Centenera, M. M. & Butler, L. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 2090.

Research output: Contribution to journalArticle