Our lab has focussed on cancer biology to bring clinical impact.
To this end we have developed a translational network of labs and clinics across Adelaide, Australia and the world to identify, develop, translate and then validate new approaches to preventing and treating gastrointestinal cancer, particularly colorectal and gastric cancer. Our laboratory is based at SAHMRI, but we collect tissues and perform human studies across every major metropolitan public hospital in South Australia as well as St Andrews private hospital. We have established two biotech companies, and collaborate with researchers from Columbia University, Oxford University, Melbourne University and University of Queensland.
Our major projects at the moment are:
1. Engineering probiotics to detect and prevent colorectal cancer.
2. Identifying new therapeutic targets in the colorectal cancer stroma.
3. Developing new prevention and treatment for patients with an inherited form of gastric cancer, GAPPS.
4. Studying human tumour organoids to better personalise therapy in cancer.