Research Output per year
Research Output per year
Personal profile
Public Profile
Research Focus:
Our lab has focussed on cancer biology to bring clinical impact.
To this end we have developed a translational network of labs and clinics across Adelaide, Australia and the world to identify, develop, translate and then validate new approaches to preventing and treating gastrointestinal cancer, particularly colorectal and gastric cancer. Our laboratory is based at SAHMRI, but we collect tissues and perform human studies across every major metropolitan public hospital in South Australia as well as St Andrews private hospital. We have established two biotech companies, and collaborate with researchers from Columbia University, Oxford University, Melbourne University and University of Queensland.
Our major projects at the moment are:
1. Engineering probiotics to detect and prevent colorectal cancer.
2. Identifying new therapeutic targets in the colorectal cancer stroma.
3. Developing new prevention and treatment for patients with an inherited form of gastric cancer, GAPPS.
4. Studying human tumour organoids to better personalise therapy in cancer.
Education/Academic qualification
PhD, Doctor of Medicine , University of Queensland
2007 → 2010
MB BS (Honours), University of Adelaide
… → 1999
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
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Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification
Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vazquez, E. G., Davis, H., East, J. E., Arnold, R., Koppens, M. A. J., Blake, A., Domingo, E., Cunningham, C., Beggs, A. D., Pestinger, V., Loughrey, M. B., Wang, L. M., Lannagan, T. R. M., Woods, S. L., Worthley, D., Consortium, S., Tomlinson, I. & 3 others, , 1 Jun 2020, In : Gut. 69, 6, p. 1092-1103 12 p.Research output: Contribution to journal › Article
6 Citations (Scopus) -
GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia
Hata, M., Kinoshita, H., Hayakawa, Y., Konishi, M., Tsuboi, M., Oya, Y., Kurokawa, K., Hayata, Y., Nakagawa, H., Tateishi, K., Fujiwara, H., Hirata, Y., Worthley, D. L., Muranishi, Y., Furukawa, T., Kon, S., Tomita, H., Wang, T. C. & Koike, K., May 2020, In : Gastroenterology. 158, 6, p. 1650-1666.e15Research output: Contribution to journal › Article
3 Citations (Scopus) -
Improving Australian National Bowel Cancer Screening Program outcomes through increased participation and cost-effective investment
Worthington, J., Lew, J. B., Feletto, E., Holden, C. A., Worthley, D. L., Miller, C. & Canfell, K., 1 Feb 2020, In : PloS one. 15, 2, e0227899.Research output: Contribution to journal › Article
2 Citations (Scopus) -
Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy
Narasimhan, V., Wright, J. A., Churchill, M., Wang, T., Rosati, R., Lannagan, T. R. M., Vrbanac, L., Richardson, A. B., Kobayashi, H., Price, T., Tye, G. X. Y., Marker, J., Hewett, P. J., Flood, M. P., Pereira, S., Whitney, G. A., Michael, M., Tie, J., Mukherjee, S., Grandori, C. & 4 others, , 15 Jul 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 14, p. 3662-3670 9 p.Research output: Contribution to journal › Article
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Pathways to a cancer-free future: A protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia
No Australians Dying of Bowel Cancer & Worthley, D., 21 Jun 2020, In : BMJ open. 10, 6Research output: Contribution to journal › Article