Research Output per year
Personal profile
Public Profile
Research Focus:
Our lab has focussed on cancer biology to bring clinical impact.
To this end we have developed a translational network of labs and clinics across Adelaide, Australia and the world to identify, develop, translate and then validate new approaches to preventing and treating gastrointestinal cancer, particularly colorectal and gastric cancer. Our laboratory is based at SAHMRI, but we collect tissues and perform human studies across every major metropolitan public hospital in South Australia as well as St Andrews private hospital. We have established two biotech companies, and collaborate with researchers from Columbia University, Oxford University, Melbourne University and University of Queensland.
Our major projects at the moment are:
1. Engineering probiotics to detect and prevent colorectal cancer.
2. Identifying new therapeutic targets in the colorectal cancer stroma.
3. Developing new prevention and treatment for patients with an inherited form of gastric cancer, GAPPS.
4. Studying human tumour organoids to better personalise therapy in cancer.
Education/Academic qualification
PhD, Doctor of Medicine , University of Queensland
2007 → 2010
MB BS (Honours), University of Adelaide
… → 1999
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2001 2019
Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing
Suzuki, N., Niikura, R., Ihara, S., Hikiba, Y., Kinoshita, H., Higashishima, N., Hayakawa, Y., Yamada, A., Hirata, Y., Nakata, R., Okamoto, M., Sano, M., Kushiyama, A., Ichinose, M., Woods, S. L., Worthley, D., Iwamoto, Y. & Koike, K., 1 Mar 2019, In : Cancer prevention research (Philadelphia, Pa.). 12, 3, p. 185-194 10 p.Research output: Contribution to journal › Article
Cancer-associated fibroblasts in gastrointestinal cancer
Kobayashi, H., Enomoto, A., Woods, S. L., Burt, A. D., Takahashi, M. & Worthley, D., 1 Jan 2019, In : Nature Reviews Gastroenterology and Hepatology.Research output: Contribution to journal › Review article
3
Citations
(Scopus)
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
Lannagan, T. R. M., Lee, Y. K., Wang, T., Roper, J., Bettington, M. L., Fennell, L., Vrbanac, L., Jonavicius, L., Somashekar, R., Gieniec, K., Yang, M., Ng, J. Q., Suzuki, N., Ichinose, M., Wright, J. A., Kobayashi, H., Putoczki, T. L., Hayakawa, Y., Leedham, S. J., Abud, H. E. & 10 others, 1 Apr 2019, In : Gut. 68, 4, p. 684-692 9 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing
Duan, M., Hao, J., Cui, S., Worthley, D. L., Zhang, S., Wang, Z., Shi, J., Liu, L., Wang, X., Ke, A., Cao, Y., Xi, R., Zhang, X., Zhou, J., Fan, J., Li, C. & Gao, Q., 1 Mar 2018, In : Cell Research. 28, 3, p. 359-373 15 p.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Erratum: β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer (Cancer Cell (2018) 33(1) (75–90.e7), (S153561081730510X) (10.1016/j.ccell.2017.11.007))
Renz, B. W., Takahashi, R., Tanaka, T., Macchini, M., Hayakawa, Y., Dantes, Z., Maurer, H. C., Chen, X., Jiang, Z., Westphalen, C. B., Ilmer, M., Valenti, G., Mohanta, S. K., Habenicht, A. J. R., Middelhoff, M., Chu, T., Nagar, K., Tailor, Y., Casadei, R., Di Marco, M. & 10 others, 12 Nov 2018, In : Cancer Cell. 34, 5, p. 863-867 5 p.Research output: Contribution to journal › Comment/debate