Dan Worthley


  • 2629 Citations
  • 30 h-Index

Research output per year

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Personal profile

Public Profile

Research Focus: 
Our lab has focussed on cancer biology to bring clinical impact.
To this end we have developed a translational network of labs and clinics across Adelaide, Australia and the world to identify, develop, translate and then validate new approaches to preventing and treating gastrointestinal cancer, particularly colorectal and gastric cancer. Our laboratory is based at SAHMRI, but we collect tissues and perform human studies across every major metropolitan public hospital in South Australia as well as St Andrews private hospital. We have established two biotech companies, and collaborate with researchers from Columbia University, Oxford University, Melbourne University and University of Queensland.
Our major projects at the moment are:
1. Engineering probiotics to detect and prevent colorectal cancer.
2. Identifying new therapeutic targets in the colorectal cancer stroma.
3. Developing new prevention and treatment for patients with an inherited form of gastric cancer, GAPPS.
4. Studying human tumour organoids to better personalise therapy in cancer.

Education/Academic qualification

PhD, Doctor of Medicine , University of Queensland


MB BS (Honours), University of Adelaide

… → 1999

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Research Output

Pathways to a cancer-free future: A protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia

No Australians Dying of Bowel Cancer & Worthley, D., 21 Jun 2020, In : BMJ open. 10, 6

Research output: Contribution to journalArticle

Cancer-associated fibroblasts—heroes or villains?

Gieniec, K. A., Butler, L., Worthley, D. & Woods, S. L., 13 Aug 2019, In : British Journal of Cancer. 121, 4, p. 293-302 10 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Lannagan, T. R. M., Lee, Y. K., Wang, T., Roper, J., Bettington, M. L., Fennell, L., Vrbanac, L., Jonavicius, L., Somashekar, R., Gieniec, K., Yang, M., Ng, J. Q., Suzuki, N., Ichinose, M., Wright, J. A., Kobayashi, H., Putoczki, T. L., Hayakawa, Y., Leedham, S. J., Abud, H. E. & 10 others, Yilmaz, Ö. H., Marker, J., Klebe, S., Wirapati, P., Mukherjee, S., Tejpar, S., Leggett, B. A., Whitehall, V. L. J., Worthley, D. L. & Woods, S. L., 1 Apr 2019, In : Gut. 68, 4, p. 684-692 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Roles of the mesenchymal stromal/stem cell marker meflin in cardiac tissue repair and the development of diastolic dysfunction

Hara, A., Kobayashi, H., Asai, N., Saito, S., Higuchi, T., Kato, K., Okumura, T., Bando, Y. K., Takefuji, M., Mizutani, Y., Miyai, Y., Saito, S., Maruyama, S., Maeda, K., Ouchi, N., Nagasaka, A., Miyata, T., Mii, S., Kioka, N., Worthley, D. L. & 3 others, Murohara, T., Takahashi, M. & Enomoto, A., 2 Aug 2019, In : Circulation Research. 125, 4, p. 414-430 17 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Stem cell injections for osteoarthritis of the knee

Whittle, S. L., Johnston, R. V., McDonald, S., Worthley, D., Campbell, T. M. & Buchbinder, R., 22 May 2019, In : Cochrane Database of Systematic Reviews. 2019, 5, CD013342.

Research output: Contribution to journalArticle

2 Citations (Scopus)