Christopher Proud

Professor, PhD, BSc

  • 20979 Citations
  • 82 h-Index
1975 …2020

Research output per year

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Personal profile

Public Profile

Professor Chris Proud has held numerous positions as lecturer, reader or professor in universities in the UK, Germany and Canada.
 
At the University of Dundee (Scotland), alongside his duties as Head of the Division of Molecular Physiology, he also coordinated the Medical Research Council Nutrient Sensing & Signalling Research Group.
 
From 2005-2008, he was Head of the Department of Biochemistry & Molecular Biology at the University of British Columbia, in Vancouver, Canada, where he continued his research into the molecular mechanisms that regulate protein synthesis. He also served as co-Director of that University’s Life Sciences Institute.
Chris worked at the University of Southampton from 2008 – 2014 where he led a substantial research team studying the mechanisms that control protein synthesis and ribosome biogenesis. He studied their roles in metabolic diseases such as diabetes, in cancer, in cardiovascular disorders, and in neurological processes.
He has supervised more than forty MSc or PhD students and almost fifty postdoctoral researchers.
In September 2014 Chris moved to Adelaide to take up the position of Theme Leader: Nutrition and Metabolism at the SAHMRI.
 
Chris is also a Professor in Molecular and Biomedical Science at the University of Adelaide.
 
Chris is a member of the Editorial Boards of the Biochemical Journal and f1000 Research. He holds a Visiting Professorship at China Ocean University in Qingdao.
 
His research at SAHMRI includes studies on the regulation of protein synthesis nutrients and hormones; cancer cell biology; and the molecular mechanisms involved in diet-induced inflammation, insulin resistance and type 2 diabetes. Much of this research focuses on protein kinases that control the protein synthesis machinery, i.e., mammalian target of rapamycin (mTOR), eukaryotic elongation factor 2 kinase (eEF2K) and the MAP kinase-interacting kinases (MNKs).
 
Since 2016, he has also been Director of the Lysosomal Diseases Research Unit at SAHMRI (the LDRU). In 2019, Chris was appointed to the position of Theme Leader: Lifelong Health at SAHMRI.

Education/Academic qualification

University of Bristol

University of Dundee

External positions

Visiting Professor, Ocean University of China

Professor in Molecular and Biomedical Science, University of Adelaide

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Research Output

Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling

Fedele, A. O. & Proud, C., Apr 2020, In : Bioscience Reports. 40, 4, BSR20200905.

Research output: Contribution to journalArticle

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K., Trim, P., Snel, M., Kamei, M., Martin, S., Fitter, S., Tian, S., Wang, X. & 3 others, Butler, L., Zannettino, A. & Proud, C., 1 Jan 2020, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2

Xiao, M., Xie, J., Wu, Y., Wang, G., Qi, X., Liu, Z., Wang, Y., Wang, X., Hoque, A., Oakhill, J., Proud, C. & Li, J., 13 Feb 2020, In : Cell Communication and Signaling. 18, 1, 25.

Research output: Contribution to journalArticle

The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation

Galeano Niño, J. L., Tay, S. S., Tearle, J. L. E., Xie, J., Govendir, M. A., Kempe, D., Mazalo, J., Drew, A. P., Colakoglu, F., Kummerfeld, S. K., Proud, C. & Biro, M., 5 Mar 2020, In : Journal of cell science. 133, 5

Research output: Contribution to journalArticle

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress

Xie, J., Van Damme, P., Fang, D. & Proud, C., 3 May 2019, In : Journal of Biological Chemistry. 294, 18, p. 7169-7176 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)