Christopher Proud

Professor

  • 19272 Citations
  • 79 h-Index
1975 …2019
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Personal profile

Public Profile

Professor Chris Proud has held numerous positions as lecturer, reader or professor in universities in the UK, Germany and Canada.
 
At the University of Dundee (Scotland), alongside his duties as Head of the Division of Molecular Physiology, he also coordinated the Medical Research Council Nutrient Sensing & Signalling Research Group.
 
From 2005-2008, he was Head of the Department of Biochemistry & Molecular Biology at the University of British Columbia, in Vancouver, Canada, where he continued his research into the molecular mechanisms that regulate protein synthesis. He also served as co-Director of that University’s Life Sciences Institute.
Chris worked at the University of Southampton from 2008 – 2014 where he led a substantial research team studying the mechanisms that control protein synthesis and ribosome biogenesis. He studied their roles in metabolic diseases such as diabetes, in cancer, in cardiovascular disorders, and in neurological processes.
He has supervised more than forty MSc or PhD students and almost fifty postdoctoral researchers.
In September 2014 Chris moved to Adelaide to take up the position of Theme Leader: Nutrition and Metabolism at the SAHMRI.
 
Chris is also a Professor in Molecular and Biomedical Science at the University of Adelaide.
 
Chris is a member of the Editorial Boards of the Biochemical Journal and f1000 Research. He holds a Visiting Professorship at China Ocean University in Qingdao.
 
His research at SAHMRI includes studies on the regulation of protein synthesis nutrients and hormones; cancer cell biology; and the molecular mechanisms involved in diet-induced inflammation, insulin resistance and type 2 diabetes. Much of this research focuses on protein kinases that control the protein synthesis machinery, i.e., mammalian target of rapamycin (mTOR), eukaryotic elongation factor 2 kinase (eEF2K) and the MAP kinase-interacting kinases (MNKs).
 
Since 2016, he has also been Director of the Lysosomal Diseases Research Unit at SAHMRI (the LDRU).

Education / Academic qualification

University of Bristol

University of Dundee

External positions

Visiting Professor, Ocean University of China

Professor in Molecular and Biomedical Science, University of Adelaide

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Research Output 1975 2019

1 Citations

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

Jin, X., Merrett, J., Tong, S., Flower, B., Xie, J., Yu, R., Tian, S., Gao, L., Zhao, J., Wang, X., Jiang, T. & Proud, C. G. 15 Jan 2019 In : European Journal of Medicinal Chemistry. p. 735-751 17 p.

Research output: Research - peer-reviewArticle

The MAP kinase-interacting kinases (MNKs) as targets in oncology

Xie, J., Merrett, J. E., Jensen, K. B. & Proud, C. G. 2019 (Accepted/In press) In : Expert Opinion on Therapeutic Targets.

Research output: Research - peer-reviewArticle

Adult mouse eIF2Bϵ Arg191His astrocytes display a normal integrated stress response in vitro

Wisse, L. E., Ter Braak, T. J., Van De Beek, M. C., Van Berkel, C. G. M., Wortel, J., Heine, V. M., Proud, C. G., Van Der Knaap, M. S. & Abbink, T. E. M. 1 Jan 2018 In : Scientific Reports. 8, 1, 3773

Research output: Research - peer-reviewArticle

1 Citations

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

Xie, J., Shen, K., Lenchine, R. V., Gethings, L. A., Trim, P. J., Snel, M. F., Zhou, Y., Kenney, J. W., Kamei, M., Kochetkova, M., Wang, X. & Proud, C. G. 1 May 2018 In : International Journal of Cancer. 142, 9, p. 1865-1877 13 p.

Research output: Research - peer-reviewArticle

Lysosomal N-acetyltransferase interacts with ALIX and is detected in extracellular vesicles

Fedele, A. O., Isenmann, S., Kamei, M., Snel, M., Trim, P., Proud, C. & Hopwood, J. 1 Oct 2018 In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 10, p. 1451-1464 14 p.

Research output: Research - peer-reviewArticle