Barbara McClure

Dr, B.Sc (Hons) PhD

  • Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
19962020

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Personal profile

Public Profile

Dr Barbara McClure’s research focus throughout her career has centred around haematological disorders and the mechanisms that promote survival and proliferation of malignant cells in acute leukaemia’s. She completed her PhD from The University of Adelaide for research on “The Molecular Assembly of the Granulocyte-Macrophage Colony Stimulating Factor” at the Centre for Cancer Biology, Adelaide. 

 

Dr McClure is currently an early career Post-Doctoral Researcher in the Acute Lymphoblastic Leukaemia (ALL) Research Group. The focus of Dr McClure’s research is on B-cell acute lymphoblastic leukaemia (B-ALL), the most common cancer diagnosed in children and young adults. While survival rates for children currently reach 90%, those who relapse have a poor prognosis and B-ALL remains the leading cause of non-traumatic death in children. The majority of adults that are diagnosed with ALL do not survive. Dr McClure’s research uses next generation sequencing to rapidly detect genomic lesions in B-cell ALL samples that can guide the use of targeted therapies for these patients. Models are developed to understand the molecular basis of how known and novel genomic lesions drive disease and therapeutic sensitivities assessed. Her aim is to use a precision medicine approach to specifically match treatments to an individual’s genomic lesions for better outcomes for these high-risk patients. In addition, she is currently investigating the contribution of individual’s own immune system at disease onset on treatment response.

 

Dr McClure was selected as an AMP Tomorrow Maker in 2019, where she was awarded funding to simultaneously map leukaemic cell signalling of high-risk ALL subtypes and assess targeted therapies in laboratory models. As a CSIRO STEM Professionals in Schools volunteer Dr McClure is partnered with a local Secondary School taking real life STEM skills to the classroom. She has co-authored 27 publications in peer reviewed journals.

Education/Academic qualification

PhD, School of Medicine, The University of Adelaide, Adelaide, Australia.

… → 4 Jul 2017

Bachelor's Degree, University of Adelaide

1 Mar 199021 Nov 1992

Bachelor's Degree (Honours), University of Adelaide

1 Feb 19932 Nov 1993

External positions

Affiliate Lecturer, School of Medicine, University of Adelaide

2017 → …

Research Assistant, Centre for Cancer Biology

14 Jan 199415 Aug 2015

Keywords

  • acute lymphoblastic leukaemia
  • next generation sequencing
  • gene-fusions
  • immune profiling
  • targeted therapies

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