Barbara McClure

Dr

  • 681 Citations
  • 13 h-Index
19962018
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Personal profile

Public Profile

Dr Barbara McClure has recently joined the Genomics Research group bringing with her expertise in the structure and function of cytokine receptors, proteins that tightly regulate normal haematopoiesis and whose alterations can result in haematological malignancies. Her position within the Genomics Research Team will be focused on investigating a cancer of white blood cells, Acute Lymphoblastic Leukaemia (ALL), an aggressive disease that is caused by a variety of genetic lesions. This research will focus on a new subtype of ALL, Ph-like ALL, which has an extremely poor prognosis. Using whole genome sequencing it has been identified that novel genetic fusions are present in the ALL patient samples. Mrs McClure will be cloning these novel fusion genes and determining if the products of these fusion genes are the driving force responsible the uncontrolled leukaemic cell growth. Cell systems will then be developed to investigate the altered molecular events responsible for driving proliferation, and to determine if current therapeutics can abrogate the novel driver genes function. This work will help with improvement in the early diagnostic identification of ALL subtypes and to identify better therapeutic options for this aggressive disease.

Education/Academic qualification

PhD, School of Medicine, The University of Adelaide, Adelaide, Australia.

… → 4 Jul 2017

Bachelor's Degree, University of Adelaide

1 Mar 199021 Nov 1992

Bachelor's Degree (Honours), University of Adelaide

1 Feb 19932 Nov 1993

External positions

Research Assistant, Centre for Cancer Biology

14 Jan 199415 Aug 2015

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Research Output 1996 2018

  • 681 Citations
  • 13 h-Index
  • 24 Article
  • 1 Letter

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression

McClure, B., Heatley, S., Kok, C., Sadras, T., An, J., Hughes, T., Lock, R. B., Yeung, D., Sutton, R. & White, D., 1 Apr 2018, In : British Journal of Cancer. 118, 7, p. 1000-1004 5 p.

Research output: Contribution to journalArticle

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Dhagat, U., Hercus, T. R., Broughton, S. E., Nero, T. L., Cheung Tung Shing, K. S., Barry, E. F., Thomson, C. A., Bryson, S., Pai, E. F., McClure, B., Schrader, J. W., Lopez, A. F. & Parker, M. W., 3 Oct 2018, In : mAbs. 10, 7, p. 1018-1029 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH

Sadras, T., Heatley, S. L., Kok, C. H., McClure, B. J., Yeung, D., Hughes, T. P., Sutton, R., Ziegler, D. S. & White, D. L., 1 Oct 2017, In : Cancer Genetics. 216-217, p. 86-90 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions

Sadras, T., Heatley, S. L., Kok, C. H., Dang, Y., Galbraith, K. M., McClure, B. J., Muskovic, W., Venn, N. C., Moore, S., Osborn, M., Revesz, T., Moore, A. S., Hughes, T. P., Yeung, D., Sutton, R. & White, D. L., 30 Aug 2017, In : Cancer Letters.

Research output: Contribution to journalArticle

High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment

Heatley, S., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, Y., McClure, B., Venn, N. C., Moore, S., Suttle, J. M., Law, T., Ng, A., Muskovic, W., Norris, M., Revesz, T., Osborn, M., Moore, S., Suppiah, R., Fraser, C., Alvaro, F. & 7 othersHughes, T., Mullighan, C. G., Marshall, G. M., Dalla Pozza, L., Yeung, D., Sutton, R. & White, D., Dec 2017, In : Haematologica. p. e490-e493

Research output: Contribution to journalLetter