Andrew Zannettino

Professor

  • 10842 Citations
  • 57 h-Index
1994 …2020

Research output per year

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Research Output

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2020

Allogeneic primary mesenchymal stem/stromal cell aggregates within poly(N-isopropylacrylamide-co-acrylic acid) hydrogel for osteochondral regeneration

Zhang, J., Zhang, M., Lin, R., Yun, S., Du, Y., Wang, L., Yao, Q., Zannettino, A. & Zhang, H., 1 Mar 2020, In : Applied Materials Today. 18, 100487.

Research output: Contribution to journalArticle

Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma

Cheong, C. M., Mrozik, K. M., Hewett, D., Bell, E., Panagopoulos, V., Noll, J., Licht, J. D., Gronthos, S., Zannettino, A. & Vandyke, K., 10 Apr 2020, In : Cancer Letters. 475, p. 99-108 10 p.

Research output: Contribution to journalArticle

2019

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Khoo, W. H., Ledergor, G., Weiner, A., Roden, D. L., Terry, R. L., McDonald, M. M., Chai, R. C., De Veirman, K., Owen, K. L., Opperman, K. S., Vandyke, K., Clark, J. R., Seckinger, A., Kovacic, N., Nguyen, A., Mohanty, S. T., Pettitt, J. A., Xiao, Y., Corr, A. P., Seeliger, C. & 14 othersNovotny, M., Lasken, R. S., Nguyen, T. V., Oyajobi, B. O., Aftab, D., Swarbrick, A., Parker, B., Hewett, D., Hose, D., Vanderkerken, K., Zannettino, A., Amit, I., Phan, T. G. & Croucher, P. I., 4 Jul 2019, In : Blood. 134, 1, p. 30-43 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo

Opperman, K. S., Vandyke, K., Clark, K. C., Coulter, E. A., Hewett, D. R., Mrozik, K. M., Schwarz, N., Evdokiou, A., Croucher, P. I., Psaltis, P., Noll, J. E. & Zannettino, A., 1 Aug 2019, In : Neoplasia (United States). 21, 8, p. 777-787 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)

Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability

Dutta, A. K., Fink, J. L., Grady, J. P., Morgan, G. J., Mullighan, C. G., To, L. B., Hewett, D. R. & Zannettino, A., 1 Feb 2019, In : Leukemia. 33, 2, p. 457-468 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2018

Co-fuse: a new class discovery analysis tool to identify and prioritize recurrent fusion genes from RNA-sequencing data

Paisitkriangkrai, S., Quek, K., Nievergall, E., Jabbour, A., Zannettino, A. & Kok, C., 1 Oct 2018, In : Molecular Genetics and Genomics. 293, 5, p. 1217-1229 13 p.

Research output: Contribution to journalArticle

Enhanced multi-lineage differentiation of human mesenchymal stem/stromal cells within poly(: N -isopropylacrylamide-acrylic acid) microgel-formed three-dimensional constructs

Zhang, J., Yun, S., Bi, J., Dai, S., Du, Y., Zannettino, A. & Zhang, H., 1 Jan 2018, In : Journal of Materials Chemistry B. 6, 12, p. 1799-1814 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mesenchymal progenitor cells primed with pentosan polysulfate promote lumbar intervertebral disc regeneration in an ovine model of microdiscectomy

Daly, C. D., Ghosh, P., Zannettino, A., Badal, T., Shimmon, R., Jenkin, G., Oehme, D., Jain, K., Sher, I., Vais, A., Cohen, C., Chandra, R. V. & Goldschlager, T., 1 Mar 2018, In : Spine Journal. 18, 3, p. 491-506 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

Martin, S. K., Fitter, S., El Khawanky, N., Grose, R., Walkley, C. R., Purton, L. E., Ruegg, M. A., Hall, M. N., Gronthos, S. & Zannettino, A., 1 Dec 2018, In : Scientific Reports. 8, 1, 14501.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2 Citations (Scopus)

Translation of remote control regenerative technologies for bone repair

Markides, H., McLaren, J. S., Telling, N. D., Alom, N., Al-Mutheffer, E. A., Oreffo, R. O. C., Zannettino, A., Scammell, B. E., White, L. J. & El Haj, A. J., 2018, In : Regenerative Medicine. 3, p. 9

Research output: Contribution to journalArticle

Using genomics to better define high-risk MGUS/SMM patients

Dutta, A. K., Hewett, D. R., Fink, J. L. & Zannettino, A. C. W., 27 Nov 2018, In : Oncotarget. 9, 93, p. 36549-36550 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Zoledronate Enhances the Cytotoxicity of Gamma Delta T Cell Immunotherapy in an Orthotopic Mouse Model of Osteolytic Osteosarcoma

Zysk, A., Denichilo, M., Zinonos, I., Hay, S., Liapis, V., Ponomarev, V., Zannettino, A., Evdokiou, A. & Panagopoulos, V., 12 Sep 2018, In : Journal of Cancer Science & Therapy.

Research output: Contribution to journalArticle

2017

Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer

Zysk, A., DeNichilo, M. O., Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., Ingman, W., Ponomarev, V., Atkins, G., Findlay, D., Zannettino, A. & Evdokiou, A., 1 Feb 2017, In : Cancer Letters. 386, p. 141-150 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma

Liapis, V., Zysk, A., DeNichilo, M., Zinonos, I., Hay, S., Panagopoulos, V., Shoubridge, A., Difelice, C., Ponomarev, V., Ingman, W., Atkins, G. J., Findlay, D. M., Zannettino, A. C. W. & Evdokiou, A., 1 Sep 2017, In : Cancer Medicine. 6, 9, p. 2164-2176 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment

Hewett, D. R., Vandyke, K., Lawrence, D. M., Friend, N., Noll, J. E., Geoghegan, J. M., Croucher, P. I. & Zannettino, A., 1 Dec 2017, In : Neoplasia (United States). 19, 12, p. 972-981 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
4 Citations (Scopus)

EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture & structural integrity & accelerates remodeling

Hemming, S., Cakouros, D., Codrington, J., Vandyke, K., Arthur, A., Zannettino, A. & Gronthos, S., 1 Mar 2017, In : FASEB Journal. 31, 3, p. 1011-1027 17 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

HIF-2α promotes dissemination of plasma cells in multiple myeloma by regulating CXCL12/CXCR4 and CCR1

Vandyke, K., Zeissig, M. N., Hewett, D. R., Martin, S. K., Mrozik, K. M., Cheong, C. M., Diamond, P., To, L. B., Gronthos, S., Peet, D. J., Croucher, P. I. & Zannettino, A. C. W., 15 Oct 2017, In : Cancer Research. 77, 20, p. 5452-5463 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation

Fitter, S., Matthews, M. P., Martin, S. K., Xie, J., Ooi, S. S., Walkley, C. R., Codrington, J. D., Ruegg, M. A., Hall, M. N., Proud, C. G., Gronthos, S. & Zannettino, A. C. W., 1 Jan 2017, In : Molecular and Cellular Biology. 37, 7, e00668-16.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Peroxidase enzymes inhibit osteoclast differentiation and bone resorption

Panagopoulos, V., Liapis, V., Zinonos, I., Hay, S., Leach, D. A., Ingman, W., DeNichilo, M. O., Atkins, G. J., Findlay, D. M., Zannettino, A. C. W. & Evdokiou, A., 15 Jan 2017, In : Molecular and Cellular Endocrinology. 440, p. 8-15 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress

Wallington-Beddoe, C. T., Bennett, M. K., Vandyke, K., Davies, L., Zebol, J. R., Moretti, P. A. B., Pitman, M. R., Hewett, D. R., Zannettino, A. C. W. & Pitson, S. M., 1 Jan 2017, In : Oncotarget. 8, 27, p. 43602-43616 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells

Vuckovic, S., Vandyke, K., Rickards, D. A., Mccauley Winter, P., Brown, S. H. J., Mitchell, T. W., Liu, J., Lu, J., Askenase, P. W., Yuriev, E., Capuano, B., Ramsland, P. A., Hill, G. R., Zannettino, A. C. W. & Hutchinson, A. T., 1 May 2017, In : British Journal of Haematology. 177, 3, p. 423-440 18 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70

Fitter, S., Gronthos, S., Ooi, S. S. & Zannettino, A. C. W., 1 Apr 2017, In : Stem Cells. 35, 4, p. 940-951 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Treatment of patients with Waldenström macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group

Talaulikar, D., Tam, C. S., Joshua, D., Ho, J. P., Szer, J., Quach, H., Spencer, A., Harrison, S., Mollee, P., Roberts, A. W., Horvath, N., Lee, C., Zannettino, A., Brown, R., Augustson, B., Jaksic, W., Gibson, J., Kalff, A., Johnston, A., Trotman, J. & 4 othersKalro, A., Grigoriadis, G., Ward, C. & Prince, H. M., 1 Jan 2017, In : Internal Medicine Journal. 47, 1, p. 35-49 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Tyrosine kinase receptor c-ros-oncogene 1 mediates TWIST-1 regulation of human mesenchymal stem cell lineage commitment

Camp, E., Anderson, P. J., Zannettino, A. C. W. & Gronthos, S., 1 Jan 2017, In : Bone. 94, p. 98-107 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

Walia, M. K., Ho, P. M. W., Taylor, S., Ng, A. J. M., Gupte, A., Chalk, A. M., Zannettino, A. C. W., Martin, T. J. & Walkley, C. R., 12 Apr 2016, In : eLife. 5, April 2016, e13446.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Allogeneic Mesenchymal Precursor Cells Promote Healing in Postero-lateral Annular Lesions and Improve Indices of Lumbar Intervertebral Disc Degeneration in an Ovine Model

Freeman, B. J. C., Kuliwaba, J. S., Jones, C. F., Shu, C. C., Colloca, C. J., Zarrinkalam, M. R., Mulaibrahimovic, A., Gronthos, S., Zannettino, A. C. W. & Howell, S., 1 Sep 2016, In : Spine. 41, 17, p. 1331-1339 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis

Ebert, L. M., Tan, L. Y., Johan, M. Z., Min, K. K. M., Cockshell, M. P., Parham, K. A., Betterman, K. L., Szeto, P., Boyle, S., Silva, L., Peng, A., Zhang, Y. F., Ruszkiewicz, A., Zannettino, A. C. W., Gronthos, S., Koblar, S., Harvey, N. L., Lopez, A. F., Shackleton, M. & Bonder, C. S., 1 Oct 2016, In : Angiogenesis. 19, 4, p. 463-486 24 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models

Liapis, V., Zinonos, I., Labrinidis, A., Hay, S., Ponomarev, V., Panagopoulos, V., Zysk, A., Denichilo, M., Ingman, W., Atkins, G. J., Findlay, D. M., Zannettino, A. C. W. & Evdokiou, A., 1 Mar 2016, In : Cancer Medicine. 5, 3, p. 534-545 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Engineering DN hydrogels from regenerated silk fibroin and poly(: N -vinylcaprolactam)

Whittaker, J. L., Dutta, N. K., Zannettino, A. & Choudhury, N. R., 1 Jan 2016, In : Journal of Materials Chemistry B. 4, 33, p. 5519-5533 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Identification of novel EZH2 targets regulating osteogenic differentiation in mesenchymal stem cells

Hemming, S., Cakouros, D., Vandyke, K., Davis, M. J., Zannettino, A. C. W. & Gronthos, S., 15 Jun 2016, In : Stem Cells and Development. 25, 12, p. 909-921 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death

Bhattacharya, S., Chalk, A. M., Ng, A. J. M., Martin, T. J., Zannettino, A. C., Purton, L. E., Lu, J., Baker, E. K. & Walkley, C. R., 6 Oct 2016, In : Oncogene. 35, 40, p. 5282-5294 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development

Nguyen, T. M., Arthur, A., Paton, S., Hemming, S., Panagopoulos, R., Codrington, J., Walkley, C. R., Zannettino, A. C. W. & Gronthos, S., 1 Dec 2016, In : Bone. 93, p. 12-21 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Twist-1 Enhances Bone Marrow Mesenchymal Stromal Cell Support of Hematopoiesis by Modulating CXCL12 Expression

Arthur, A., Cakouros, D., Cooper, L., Nguyen, T., Isenmann, S., Zannettino, A. C. W., Glackin, C. A. & Gronthos, S., 1 Feb 2016, In : Stem Cells. 34, 2, p. 504-509 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

Baker, E. K., Taylor, S., Gupte, A., Sharp, P. P., Walia, M., Walsh, N. C., Zannettino, A. C. W., Chalk, A. M., Burns, C. J. & Walkley, C. R., 6 May 2015, In : Scientific Reports. 5, 10120.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Bone marrow recovery by morphometry during induction chemotherapy for acute lymphoblastic leukemia in children

Nguyen, T. V., Melville, A., Nath, S., Story, C., Howell, S., Sutton, R., Zannettino, A. & Revesz, T., 11 May 2015, In : PloS one. 10, 5, e0126233.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Brief report: The differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation

Martin, S. K., Fitter, S., Dutta, A. K., Matthews, M. P., Walkley, C. R., Hall, M. N., Ruegg, M. A., Gronthos, S. & Zannettino, A. C. W., 1 Apr 2015, In : Stem Cells. 33, 4, p. 1359-1365 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance

Nguyen, T. M., Arthur, A., Panagopoulos, R., Paton, S., Hayball, J. D., Zannettino, A. C. W., Purton, L. E., Matsuo, K. & Gronthos, S., 1 Sep 2015, In : Stem Cells. 33, 9, p. 2838-2849 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma

Liapis, V., Labrinidis, A., Zinonos, I., Hay, S., Ponomarev, V., Panagopoulos, V., DeNichilo, M., Ingman, W., Atkins, G. J., Findlay, D. M., Zannettino, A. C. W. & Evdokiou, A., 1 Jan 2015, In : Cancer Letters. 357, 1, p. 160-169 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

Forristal, C. E., Brown, A. L., Helwani, F. M., Winkler, I. G., Nowlan, B., Barbier, V., Powell, R. J., Engler, G. A., Diakiw, S. M., Zannettino, A. C. W., Martin, S., Pattabiraman, D., D'Andrea, R. J., Lewis, I. D. & Levesque, J. P., 1 Oct 2015, In : Leukemia. 29, 10, p. 2075-2085 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
14 Citations (Scopus)

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

Lawson, M. A., McDonald, M. M., Kovacic, N., Khoo, W. H., Terry, R. L., Down, J., Kaplan, W., Paton-Hough, J., Fellows, C., Pettitt, J. A., Dear, T. N., Van Valckenborgh, E., Baldock, P. A., Rogers, M. J., Eaton, C. L., Vanderkerken, K., Pettit, A. R., Quinn, J. M. W., Zannettino, A. C. W., Phan, T. G. & 1 othersCroucher, P. I., 3 Dec 2015, In : Nature communications. 6, 8983.

Research output: Contribution to journalArticle

112 Citations (Scopus)
12 Citations (Scopus)