Agnes Arthur

Post-doctoral researcher, PhD, B.Sc (Hons)

  • 536 Citations
  • 5 h-Index
20082020

Research output per year

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Personal profile

Public Profile

Dr Agnes Arthur leads the Musculoskeletal Cellular Communication (MCC) research group within the Mesenchymal Stem Cell (MSC) Laboratory located at SAHMRI. Dr Arthur received her PhD (2007) from the School of Molecular and Biomedical Science at the University of Adelaide and subsequently undertook a postdoctoral position at the MSC laboratory at SA Pathology with Prof Stan Gronthos. Here she continued her interest in characterising a mesenchymal stem cell population called dental pulp stem cells (DPSC) as a potential therapy for neurological disorders. This work resulted in two patents that are currently licensed to Mesoblast Ltd. Dr Arthur also examined the maintenance of DPSC within their niche in response to Eph/ephrin signalling and its potential role in dental repair. In 2009 the direction of the research shifted towards understanding the importance of cell-cell interactions and signalling mediating the function of bone marrow derived mesenchymal stem cells. In 2013 Dr Arthur became a Mary Overton Research Fellow and an International Federation of Musculoskeletal Research Societies (IFMRS) Fellow in 2018.

Our group is interested in the communication between mesenchymal stem cells and their surrounding microenvironment. More specifically, our research centres on understanding the cellular (mesenchymal (bone/ dental), haematopoietic, immune, neural) communication within neural and skeletal tissue, with a focus on Eph-ephrin signalling in bone metabolism under steady state, disease and trauma induced conditions, including osteoporosis and femoral fracture repair.

Keywords

  • bone biology
  • osteoporosis
  • fracture repair
  • Mesenchymal stem cells
  • osteoblasts
  • osteoclasts
  • chondrocytes
  • Eph and ephrin molecules
  • nerve

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Research Output

  • 536 Citations
  • 5 h-Index
  • 6 Article
  • 1 Abstract
  • 1 Poster

Generation of Neural Crest-Like Cells From Human Periodontal Ligament Cell-Derived Induced Pluripotent Stem Cells

Tomokiyo, A., Hynes, K., Ng, J., Menicanin, D., Camp, E., Arthur, A., Gronthos, S. & Mark Bartold, P., 1 Feb 2017, In : Journal of Cellular Physiology. 232, 2, p. 402-416 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

EphB and ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells

Nguyen, T. M., Arthur, A., Hayball, J. D. & Gronthos, S., 15 Oct 2013, In : Stem Cells and Development. 22, 20, p. 2751-2764 14 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms

Leong, W. K., Henshall, T. L., Arthur, A., Kremer, K. L., Lewis, M. D., Helps, S. C., Field, J., Hamilton-Bruce, M. A., Warming, S., Manavis, J., Vink, R., Gronthos, S. & Koblar, S. A., 1 Jan 2012, In : Stem Cells Translational Medicine. 1, 3, p. 177-187 11 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Human adult stem cells as a treatment for focal cerebral ischemia

Leong, W. K., Arthur, A., Warming, S., Lewis, M., Gronthos, S. & Koblar, S., Aug 2011.

Research output: Contribution to conferencePoster