Adeline Bowen

Dr

  • 264 Citations
  • 8 h-Index
20042018
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Personal profile

Public Profile

Dr Adeline Lau joined the Childhood Dementia Research group (formerly the CNS Therapeutics Section) in the Hopwood Centre for Neurobiology (formerly the Lysosomal Diseases Research Unit) in 2001. She was awarded an NHMRC Biomedical (Dora Lush) Postgraduate Research Scholarship to examine the clinical efficacy of a gene therapy approach for mucopolysaccharidosis type IIIA (MPS IIIA), a neurological lysosomal storage disorder, under the supervision of Dr Kim Hemsley and Professor John Hopwood. As part of these studies, she was a visiting scientist at the Institut de Génétique Moléculaire de Montpellier in France, where she generated gene transfer vectors in the laboratory of Dr Eric Kremer. Adeline’s research has focused on evaluating novel, long-term therapies for children affected by MPS IIIA, and understanding how pathology develops in this disorder to make treatments more effective. 

Research Interests

  • Neurological disorders
  • Behavioural phenotyping
  • Viral vectors
  • Bone marrow transplantation
  • Brain-directed therapies

Education/Academic qualification

Bachelor's Degree (Honours), Flinders University

PhD, University of Adelaide

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Research Output 2004 2018

  • 264 Citations
  • 8 h-Index
  • 13 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate

MPS-IIIA mice acquire autistic behaviours with age

Lau, A. A., Hemsley, K. M. & Tamang, S., 1 Jul 2018, In : Journal of Inherited Metabolic Disease. 41, 4, p. 669-677 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer's disease

Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J. & Sargeant, T. J., 15 Jan 2018, In : Behavioural Brain Research. 336, p. 177-181 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration

Lau, A. A. & Hemsley, K. M., 29 Jun 2017, In : Journal of Molecular Medicine.

Research output: Contribution to journalReview article

1 Citation (Scopus)

A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome

Lau, A. A., King, B. M., Thorsen, C. L., Hassiotis, S., Beard, H., Trim, P. J., Whyte, L. S., Tamang, S. J., Duplock, S. K., Snel, M. F., Hopwood, J. J. & Hemsley, K. M., 27 Apr 2017, (Accepted/In press) In : Journal of Inherited Metabolic Disease. 40, 5, p. 1-10 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J. & Sargeant, T. J., 1 Mar 2017, In : Journal of Neurochemistry. 140, 5, p. 703-717 15 p.

Research output: Contribution to journalReview article

Prizes

Alice Davey Award

Kim Hemsley (Recipient), Leanne K. Winner (Recipient), Helen Beard (Recipient), Sofia Hassiotis (Recipient), Adeline Bowen (Recipient), Amanda J. Luck (Recipient) & John J. Hopwood (Recipient), Oct 2017

Prize