Adeline Bowen

Dr

  • 285 Citations
  • 9 h-Index
20042019
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Personal profile

Public Profile

Dr Adeline Lau joined the Childhood Dementia Research group in the Hopwood Centre for Neurobiology (formerly the Lysosomal Diseases Research Unit) in 2001. She was awarded an NHMRC Biomedical (Dora Lush) Postgraduate Research Scholarship to examine the clinical efficacy of a gene therapy approach for mucopolysaccharidosis type IIIA (MPS IIIA), a neurological lysosomal storage disorder, under the supervision of A. Prof. Kim Hemsley and Em. Prof. John Hopwood. As part of these studies, she was a visiting scientist at the Institut de Génétique Moléculaire de Montpellier (France) in the laboratory of Dr Eric Kremer. Adeline’s research has evaluated therapies such as bone marrow transplantation, stem cell therapy, non-human adenoviral and AAV gene transfer and small molecule drugs. She also has an interest in understanding how the pathology develops and in characterising the clinical phenotype of this disease in mammalian and invertebrate animal models.

 

Research Interests

  • Neurological disorders
  • Behavioural phenotyping
  • Gene therapy
  • Small molecule drugs

Education/Academic qualification

Bachelor's Degree (Honours), Flinders University

PhD, University of Adelaide

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Research Output 2004 2019

  • 285 Citations
  • 9 h-Index
  • 15 Article
  • 2 Review article
  • 1 Chapter
  • 1 Comment/debate

Canine adenoviral vector-mediated gene transfer to the guinea pig brain

Lau, A. A., Hopwood, J. & Hemsley, K., 2019, In : Gene Reports. 16, 100432

Research output: Contribution to journalArticle

Open Access

Synthetic Disaccharide Standards Enable Quantitative Analysis of Stored Heparan Sulfate in MPS IIIA Murine Brain Regions

He, Q. Q., Trim, P. J., Lau, A. A., King, B. M., Hopwood, J. J., Hemsley, K. M., Snel, M. F. & Ferro, V., 21 Aug 2019, In : ACS Chemical Neuroscience. 10, 8, p. 3847-3858 12 p.

Research output: Contribution to journalArticle

MPS-IIIA mice acquire autistic behaviours with age

Lau, A. A., Hemsley, K. M. & Tamang, S., 1 Jul 2018, In : Journal of Inherited Metabolic Disease. 41, 4, p. 669-677 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer's disease

Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J. & Sargeant, T. J., 15 Jan 2018, In : Behavioural Brain Research. 336, p. 177-181 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration

Lau, A. A. & Hemsley, K. M., 29 Jun 2017, In : Journal of Molecular Medicine.

Research output: Contribution to journalReview article

Prizes

Alice Davey Award

Kim Hemsley (Recipient), Leanne K. Winner (Recipient), Helen Beard (Recipient), Sofia Hassiotis (Recipient), Adeline Bowen (Recipient), Amanda J. Luck (Recipient) & John Hopwood (Recipient), Oct 2017

Prize