Research Output per year
Personal profile
Public Profile
Dr Adeline Lau joined the Childhood Dementia Research group (formerly the CNS Therapeutics Section) in the Hopwood Centre for Neurobiology (formerly the Lysosomal Diseases Research Unit) in 2001. She was awarded an NHMRC Biomedical (Dora Lush) Postgraduate Research Scholarship to examine the clinical efficacy of a gene therapy approach for mucopolysaccharidosis type IIIA (MPS IIIA), a neurological lysosomal storage disorder, under the supervision of Dr Kim Hemsley and Professor John Hopwood. As part of these studies, she was a visiting scientist at the Institut de Génétique Moléculaire de Montpellier in France, where she generated gene transfer vectors in the laboratory of Dr Eric Kremer. Adeline’s research has focused on evaluating novel, long-term therapies for children affected by MPS IIIA, and understanding how pathology develops in this disorder to make treatments more effective.
Research Interests
- Neurological disorders
- Behavioural phenotyping
- Viral vectors
- Bone marrow transplantation
- Brain-directed therapies
Education / Academic qualification
Bachelor's Degree (Honours), Flinders University
PhD, University of Adelaide
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2004 2018
MPS-IIIA mice acquire autistic behaviours with age
Lau, A. A., Hemsley, K. M. & Tamang, S. 1 Jul 2018 In : Journal of Inherited Metabolic Disease. 41, 4, p. 669-677 9 p.Research output: Research - peer-review › Article
Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer's disease
Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J. & Sargeant, T. J. 15 Jan 2018 In : Behavioural Brain Research. 336, p. 177-181 5 p.Research output: Research - peer-review › Article
Adeno-associated viral gene therapy for mucopolysaccharidoses exhibiting neurodegeneration
Lau, A. A. & Hemsley, K. M. 29 Jun 2017 In : Journal of Molecular Medicine.Research output: Research - peer-review › Review article
A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome
Lau, A. A., King, B. M., Thorsen, C. L., Hassiotis, S., Beard, H., Trim, P. J., Whyte, L. S., Tamang, S. J., Duplock, S. K., Snel, M. F., Hopwood, J. J. & Hemsley, K. M. 27 Apr 2017 (Accepted/In press) In : Journal of Inherited Metabolic Disease. 40, 5, p. 1-10 10 p.Research output: Research - peer-review › Article
Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?
Whyte, L. S., Lau, A. A., Hemsley, K. M., Hopwood, J. J. & Sargeant, T. J. 1 Mar 2017 In : Journal of Neurochemistry. 140, 5, p. 703-717 15 p.Research output: Research - peer-review › Review article
Prizes
Alice Davey Award
Kim Hemsley (Recipient), Leanne K. Winner (Recipient), Helen Beard (Recipient), Sofia Hassiotis (Recipient), Adeline Bowen (Recipient), Amanda J. Luck (Recipient) & John J. Hopwood (Recipient), Oct 2017
Prize