The Makinen EMBL Australia Group

Research Output 2004 2020

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2020

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease

Ohukainen, P., Kuusisto, S., Kettunen, J., Perola, M., Järvelin, M. R., Makinen, V-P. & Ala-Korpela, M., 1 Feb 2020, In : Atherosclerosis. 294, p. 10-15 6 p.

Research output: Contribution to journalArticle

2019

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: An interventional study

Wang, Q., Jokelainen, J., Auvinen, J., Puukka, K., Keinänen-Kiukaanniemi, S., Järvelin, M. R., Kettunen, J., Makinen, V-P. & Ala-Korpela, M., 29 Nov 2019, In : BMC Medicine. 17, 1, 217.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Numero: a statistical framework to define multivariable subgroups in complex population-based datasets

Gao, S., Mutter, S., Casey, A. & Makinen, V-P., 1 Jan 2019, In : International Journal of Epidemiology. 48, 2, p. 369-374 6 p.

Research output: Contribution to journalArticle

Statistical reporting of metabolomics data: experience from a high-throughput NMR platform and epidemiological applications

Mutter, S., Worden, C., Paxton, K. & Makinen, V-P., 19 Dec 2019, In : Metabolomics. 16, 1, 5.

Research output: Contribution to journalArticle

2018
30 Citations (Scopus)

A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., William Rayner, N., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E., Loredana Marcovecchio, M., Igo, R. P., Salem, R. M., Perico, N. & 578 othersLajer, M., Käräjämäki, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., Van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Clara, T. S. H., McKnight, A. J., Duffy, S., Warren, Pezzolesi, M. G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Ahluwalia, T. S., Almgren, P., Schulz, C. A., Orho-Melander, M., Linneberg, A., Christensen, C., Witte, D. R., Grarup, N., Brandslund, I., Melander, O., Paterson, A. D., Tregouet, D., Maxwell, A. P., Lim, S. C., Ma, R. C. W., Shyong Tai, E., Maeda, S., Lyssenko, V., Tuomi, T., Krolewski, A. S., Rich, S. S., Hirschhorn, J. N., Florez, J. C., Dunger, D., Pedersen, O., Hansen, T., Rossing, P., Remuzzi, G., Brosnan, M. J., Palmer, C. N. A., Groop, P. H., Colhoun, H. M., Groop, L. C., McCarthy, M. I., Koivula, S., Uggeldahl, T., Forslund, T., Halonen, A., Koistinen, A., Koskiaho, P., Laukkanen, M., Saltevo, J., Tiihonen, M., Forsen, M., Granlund, H., Jonsson, A. C., Nyroos, B., Kinnunen, P., Orvola, A., Salonen, T., Vähänen, A., Paldanius, K. R., Riihelä, M., Ryysy, L., Laukkanen, K. H., Nyländen, P., Sademies, A., Anderson, S., Asplund, B., Byskata, U., Liedes, P., Kuusela, M., Virkkala, T., Nikkola, A., Ritola, E., Niska, T. M., Saarinen, H., Oukko-Ruponen, S. E., Virtanen, T., Lyytinen, V. A., Kari, P. H., Simonen, T., Kaprio, S. A., Kärkkäinen, J., Rantaeskola, B., Kääriäinen, T. P., Haaga, J., Pietiläinen, A. L., Klemetti, S., Nyandoto, T., Rontu, E., Satuli-Autere, S., Toivonen, K. R., Lansimaki, H. V., Ahonen, R., Ivaska-Suomela, M., Jauhiainen, A., Laine, M. M., Pellonpää, T., Puranen, R., Airas, M. A., Laakso, J., Rautavaara, K., Erola, R. M., Jatkola, E., Lönnblad, T. R., Malm, A., Mäkelä, J., Rautamo, E., Hentunen, P., Lagerstam, J., Feodoroff, M., Gordin, D., Heikkilä, O., Hietala, K., Fagerudd, J., Korolainen, M., Kyllönen, L., Kytö, J., Lindh, S., Pettersson-Fernholm, K., Rosengård-Bärlund, M., Sandelin, A., Thorn, L., Tuomikangas, J., Vesisenaho, T., Wadén, J., Sipilä, V., Kalliomäki, F. T., Koskelainen, J., Nikkanen, R., Savolainen, N., Sulonen, H., Valtonen, E., Norvio, L., Hämäläinen, A., Toivanen, E., Parta, J. A., Pirttiniemi, I., Aranko, S., Ervasti, S., Kauppinen-Mäkelin, R., Kuusisto, A., Leppälä, T., Nikkilä, K., Pekkonen, L., Jokelainen, K. S., Kananen, K., Karjalainen, M., Kemppainen, P., Mankinen, A. M., Reponen, A., Sankari, M., Suominen, P., Lappalainen, A., Liimatainen, M., Santaholma, J., Aimolahti, A., Huovinen, E., Ilkka, V., Lehtimäki, M., Pälikkö-Kontinen, E., Vanhanen, A., Koskinen, E., Siitonen, T., Huttunen, E., Ikäheimo, R., Karhapää, P., Kekäläinen, P., Laakso, M., Lakka, T., Lampainen, E., Moilanen, L., Tanskanen, S., Niskanen, L., Tuovinen, U., Vauhkonen, I., Voutilainen, E., Huang, Y., Lan, H. Y., Lok, S., Tomlinson, B., Tsui, S. K. W., Yu, W., Yip, K. Y. L., Chan, T. F., Fan, X., Tang, N., Tian, X., Chan, K. K. H., Xie, F., Ng, A. C. W., Cheung, G. P. Y., Yeung, M. W., Mai, S., Xie, F., Zhang, S., Yu, P., Weng, M., Savage, D. A., Walker, J., Thomas, S., Viberti, G. C., Boulton, A. J. M., Marshall, S., Demaine, A. G., Millward, B. A., Bain, S. C., Makinen, V-P., Ahola, A. J., Dahlström, E., Gordin, D., Heikkilä, O., Hietala, K., Kytö, J., Lehto, M., Lithovius, R., Panduru, N. M., Parkkonen, M., Rosengård-Bärlund, M., Saraheimo, M., Söderlund, J., Soro-Paavonen, A., Syreeni, A., Thorn, L. M., Tolonen, N., Wadén, J., McKay, G. J., Isakova, T., Guiducci, C., Taylor, A., Mirel, D. B., Williams, W. W., Brennan, E. P., Sadlier, D. M., Martin, F., Godson, C., Mayer, L., Gubitosi-Klug, R., Bourne, P., Schutta, M., Lackaye, M. E., Gregory, N. S., Kruger, D., Jones, J. K., Bhan, A., Golden, E., Aiello, L., Larkin, M., Nathan, D., Ziegler, G., Caulder, S., Pittman, C., Luttrell, L., Lopes-Virella, M., Johnson, M., Gunyou, K., Bergenstal, R., Vittetoe, B., Sivitz, W., Flaherty, N., Bantle, J., Hitt, S., Goldstein, D., Hainsworth, D., Cimino, L., Orchard, T., Wigley, C., Dagogo-Jack, S., Strowig, S., Raskin, P., Barnie, A., Zinman, B., Fahlstrom, R., Palmer, J., Harth, J., Driscoll, M., McDonald, C., Lipps Hagan, J., May, M., Levandoski, L., White, N., Gatcomb, P., Tamborlane, W., Adelman, D., Colson, S., Molitch, M., Lorenzi, G., Mudaliar, S., Johnsonbaugh, S., Miller, R., Canady, J., Schade, D., Bernal, M. L., Malone, J., Morrison, A., Martin, C., Herman, W., Pop-Busui, R., Cowie, C., Leschek, E., Cleary, P., Lachin, J., Zinman, B., Lorenzi, G., Braffett, B., Steffes, M., Arends, V., Blodi, B., Danis, R., Lawrence, D., Wabers, H., Soliman, E., Zhang, Z. M., Campbell, C., Hensley, S., Keasler, L., Mark, M., Albertini, M., Boustany, C., Ehlgen, A., Gerl, M., Huber, J., Schölch, C., Zimdahl-Gelling, H., Agardh, E., Ajanki, T., Al Maghrabi, N., Apelqvist, J., Bengtsson, E., Berglund, L., Björckbacka, H., Blom-Nilsson, U., Borell, M., Burström, A., Cilio, C., Cinthio, M., Dreja, K., Dunér, P., Engelbertsen, D., Fadista, J., Gomez, M., Goncalves, I., Hedblad, B., Hultgårdh, A., Johansson, M. E., Kennbäck, C., Kravic, J., Lernmark, A., Lindholm, E., Ling, C., Luthman, H., Neptin, M., Nilsson, J., Nilsson, P., Nilsson, T., Nordin, G., Ottoson-Laakso, E., Persson, A., Persson, M., Persson, M. A., Postma, J., Pranter, E., Rattik, S., Sterner, G., Tindberg, L., Wigren, M., Zetterqvist, A., Åkerlund, M., Ostling, G., Kanninen, T., Ahonen-Bishopp, A., Eliasson, A., Herrala, T., Tikka-Kleemola, P., Hamsten, A., Betsholtz, C., Björkholm, A., Foroogh, F., Genové, G., Gertow, K., Gigante, B., He, B., Leander, K., McLeod, O., Nastase-Mannila, M., Patrakka, J., Silveira, A., Strawbridge, R., Tryggvason, K., Vikström, M., Ohrvik, J., Österholm, A. M., Thorand, B., Gieger, C., Grallert, H., Ludwig, T., Nitz, B., Schneider, A., Wang-Sattler, R., Zierer, A., Benigni, A., Donadelli, R., Lesti, M. D., Noris, M., Piras, R., Ruggenenti, P., Chassin, L., Dalton, N., Deanfield, J., Horsford, J., Rice, C., Rudd, J., Walker, N., Whitehead, K., Wong, M., Adams, F., Akbar, T., Belch, J., Dove, F., Ellingford, A., Farran, B., Ferguson, M., Henderson, G., Houston, G., Khan, F., Leese, G., Livingstone, S., Looker, H., McCann, M., McGurnaghan, S., Morris, A., Newton, D., Pearson, E., Reekie, G., Smith, N., Shore, A., Aizawa, K., Ball, C., Bellenger, N., Casanova, F., Frayling, T., Gates, P., Gooding, K., Hattersley, A., Ling, R., Mawson, D., Shandas, R., Strain, D., Thorn, C., Smith, U., Hammarstedt, A., Häring, H., Sesti, G., Fagerholm, E., Parkkonen, M., Tolonen, N., Toppila, I., Salomaa, V., Havulinna, A., Kristiansson, K., Okamo, P., Peltola, T., Perola, M., Pietilä, A., Ripatti, S., Taimi, M., Ylä-Herttuala, S., Babu, M., Dijkstra, M., Gurzeler, E., Huusko, J., Kholová, I., Laakso, M., Merentie, M., Poikolainen, M., Groves, C., Juliusdottir, T., Karpe, F., Lagou, V., Morris, A., Cobelli, C., Di Camillo, B., Finotello, F., Sambo, F., Toffolo, G., Trifoglio, E., Bellazzi, R., Barbarini, N., Bucalo, M., Larizza, C., Magni, P., Malovini, A., Marini, S., Mulas, F., Quaglini, S., Sacchi, L., Vitali, F., Ferrannini, E., Boldrini, B., Kozakova, M., Mari, A., Morizzo, C., Mota, L., Natali, A., Palombo, C., Venturi, E., Walker, M., Patrono, C., Pagliaccia, F., Rocca, B., Nuutila, P., Haukkala, J., Knuuti, J., Roivainen, A., Saraste, A., McKeague, P., Colombo, M., Steckel-Hamann, B., Bokvist, K., Shankar, S., Thomas, M., Gan, L. M., Heinonen, S., Jönsson-Rylander, A. C., Momo, R., Schnecke, V., Unwin, R., Walentinsson, A., Whatling, C., Nogoceke, E., Pacheco, G. D., Formentini, I., Schindler, T., Tortoli, P., Bassi, L., Boni, E., Dallai, A., Guidi, F., Lenge, M., Matera, R., Ramalli, A., Ricci, S., Viti, J., Jablonka, B., Crowther, D., Gassenhuber, J., Hess, S., Hubschle, T., Juretschke, H. P., Rutten, H., Sadowski, T., Wohlfart, P., Clerin, V., Hyde, C., Malarstig, A., Pullen, N., Tilley, M., Tuthill, T. & Vangjeli, C., 1 Jul 2018, In : Diabetes. 67, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease

Gao, S., Casey, A., Sargeant, T. & Makinen, V-P., 1 Sep 2018, In : Brain. 141, 9, p. 2711-2720 10 p.

Research output: Contribution to journalArticle

Open Access
2017
38 Citations (Scopus)

Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line

Yusufi, F. N. K., Lakshmanan, M., Ho, Y. S., Loo, B. L. W., Ariyaratne, P. N., Yang, Y., Ng, S. K., Tan, T. R. M., Yeo, H. C., Lim, H. L., Ng, S. W., Hiu, A. P., Chow, C. P., Wan, C., Chen, S., Teo, G., Song, G., Chin, J. X., Ruan, X., Sung, K. W. K. & 5 othersHu, W. S., Yap, M. G. S., Bardor, M., Nagarajan, N. & Lee, D. Y., 24 May 2017, In : Cell Systems. 4, 5, p. 530-542.e6

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016
21 Citations (Scopus)

Mergeomics: Multidimensional data integration to identify pathogenic perturbations to biological systems

Shu, L., Zhao, Y., Kurt, Z., Byars, S. G., Tukiainen, T., Kettunen, J., Orozco, L. D., Pellegrini, M., Lusis, A. J., Ripatti, S., Zhang, B., Inouye, M., Makinen, V-P. & Yang, X., 4 Nov 2016, In : BMC Genomics. 17, 1, 874.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Mergeomics: A web server for identifying pathological pathways, networks, and key regulators via multidimensional data integration

Arneson, D., Bhattacharya, A., Shu, L., Mäkinen, V. P. & Yang, X., 9 Sep 2016, In : BMC Genomics. 17, 1, 722.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Wang, Q., Würtz, P., Auro, K., Makinen, V-P., Kangas, A. J., Soininen, P., Tiainen, M., Tynkkynen, T., Jokelainen, J., Santalahti, K., Salmi, M., Blankenberg, S., Zeller, T., Viikari, J., Kähönen, M., Lehtimäki, T., Salomaa, V., Perola, M., Jalkanen, S., Järvelin, M. R. & 4 othersRaitakari, O. T., Kettunen, J., Lawlor, D. A. & Ala-Korpela, M., 13 Dec 2016, In : BMC Medicine. 14, 1, p. 205

Research output: Contribution to journalArticle

2 Citations (Scopus)

Oxygen deteriorates arterial function in type 1 diabetes

Gordin, D., Bernardi, L., Rosengård-Bärlund, M., Mäkinen, V. P., Soro-Paavonen, A., Forsblom, C., Sandelin, A. & Groop, P. H., 1 Jun 2016, In : Acta Diabetologica. 53, 3, p. 349-357 9 p.

Research output: Contribution to journalArticle

2015
14 Citations (Scopus)

High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells

Fogarty, C. L., Nieminen, J. K., Peräneva, L., Lassenius, M. I., Ahola, A. J., Taskinen, M. R., Jauhiainen, M., Kirveskari, J., Pussinen, P., Hörkkö, S., Mäkinen, V. P., Gordin, D., Forsblom, C., Groop, P. H., Vaarala, O. & Lehto, M., 3 Sep 2015, In : Acta Diabetologica. 52, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification and characterisation of synaptonemal complex genes in monotremes

Casey, A. E., Daish, T. J. & Grutzner, F., 1 Jan 2015, In : Gene. 567, 2, p. 146-153 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., Paananen, J., Hansson, O., Pankow, J., Goodarzi, M. O., Carcamo-Orive, I., Morris, A. P., Chen, Y. D. I., Mäkinen, V. P., Ganna, A., Mahajan, A., Guo, X., Abbasi, F., Greenawalt, D. M., Lum, P., Molony, C. & 20 othersLind, L., Lindgren, C., Raffel, L. J., Tsao, P. S., Schadt, E. E., Rotter, J. I., Sinaiko, A., Reaven, G., Yang, X., Hsiung, C. A., Groop, L., Cordell, H. J., Laakso, M., Hao, K., Ingelsson, E., Frayling, T. M., Weedon, M. N., Walker, M., Quertermous, T. & The RISC (Relationship between Insulin 1Sensitivity and Cardiovascular Disease) Consortium The EUGENE2 (European Network on Functional Genomics of Type 2 Diabetes) Study The GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium, 1 Apr 2015, In : Journal of Clinical Investigation. 125, 4, p. 1739-1751 13 p.

Research output: Contribution to journalArticle

2014
4 Citations (Scopus)

Arterial function can be obtained by noninvasive finger pressure waveform

Bernardi, L., Gordin, D., Rosengård-Bärlund, M., Mäkinen, V. P., Mereu, R., Ditoro, A. & Groop, P. H., 15 Jul 2014, In : International Journal of Cardiology. 175, 1, p. 169-171 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Different lipid variables predict incident coronary artery disease in patients with type 1 diabetes with or without diabetic nephropathy: The FinnDiane study

Tolonen, N., Forsblom, C., Mäkinen, V. P., Harjutsalo, V., Gordin, D., Feodoroff, M., Sandholm, N., Thorn, L. M., Wadén, J., Taskinen, M. R. & Groop, P. H., 1 Jan 2014, In : Diabetes Care. 37, 8, p. 2374-2382 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes

Sandholm, N., Forsblom, C., Mäkinen, V. P., McKnight, A. J., Österholm, A. M., He, B., Harjutsalo, V., Lithovius, R., Gordin, D., Parkkonen, M., Saraheimo, M., Thorn, L. M., Tolonen, N., Wadén, J., Tuomilehto, J., Lajer, M., Ahlqvist, E., Möllsten, A., Marcovecchio, M. L., Cooper, J. & 8 othersDunger, D., Paterson, A. D., Zerbini, G., Groop, L., Tarnow, L., Maxwell, A. P., Tryggvason, K. & Groop, P. H., 1 Jan 2014, In : Diabetologia. 57, 6, p. 1143-1153 11 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V. P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., Nikpay, M., Stewart, A. F. R., Nelson, C. P., Willenborg, C., Erdmann, J., Blakenberg, S., O'Donnell, C. J., März, W., Laaksonen, R., Epstein, S. E. & 11 othersKathiresan, S., Shah, S. H., Hazen, S. L., Reilly, M. P., Lusis, A. J., Samani, N. J., Schunkert, H., Quertermous, T., McPherson, R., Yang, X. & Assimes, T. L., 1 Jan 2014, In : PLoS genetics. 10, 7, e1004502.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification

Sambo, F., Malovini, A., Sandholm, N., Stavarachi, M., Forsblom, C., Mäkinen, V. P., Harjutsalo, V., Lithovius, R., Gordin, D., Parkkonen, M., Saraheimo, M., Thorn, L. M., Tolonen, N., Wadén, J., He, B., Österholm, A. M., Tuomilehto, J., Lajer, M., Salem, R. M., McKnight, A. J. & 9 othersTarnow, L., Panduru, N. M., Barbarini, N., Di Camillo, B., Toffolo, G. M., Tryggvason, K., Bellazzi, R., Cobelli, C. & Groop, P. H., 1 Jan 2014, In : Diabetologia. 57, 8, p. 1611-1622 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals

Lassenius, M. I., Mäkinen, V. P., Fogarty, C. L., Peräneva, L., Jauhiainen, M., Pussinen, P. J., Taskinen, M. R., Kirveskari, J., Vaarala, O., Nieminen, J. K., Hörkkö, S., Kangas, A. J., Soininen, P., Ala-Korpela, M., Gordin, D., Ahola, A. J., Forsblom, C., Groop, P. H. & Lehto, M., 13 Jun 2014, In : Nutrition and Metabolism. 11, 1, 28.

Research output: Contribution to journalArticle

86 Citations (Scopus)

The Opisthorchis viverrini genome provides insights into life in the bile duct

Young, N. D., Nagarajan, N., Lin, S. J., Korhonen, P. K., Jex, A. R., Hall, R. S., Safavi-Hemami, H., Kaewkong, W., Bertrand, D., Gao, S., Seet, Q., Wongkham, S., Teh, B. T., Wongkham, C., Intapan, P. M., Maleewong, W., Yang, X., Hu, M., Wang, Z., Hofmann, A. & 4 othersSternberg, P. W., Tan, P., Wang, J. & Gasser, R. B., 9 Jul 2014, In : Nature communications. 5, 4378.

Research output: Contribution to journalArticle

2013
17 Citations (Scopus)

Associations and interactions between lipid profiles, retinopathy and nephropathy in patients with type 1 diabetes: The FinnDiane study

Tolonen, N., Hietala, K., Forsblom, C., Harjutsalo, V., Mäkinen, V. P., Kytö, J., Summanen, P. A., Thorn, L. M., Wadén, J., Gordin, D., Taskinen, M. R. & Groop, P. H., 1 Nov 2013, In : Journal of Internal Medicine. 274, 5, p. 469-479 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Chromosome 2q31. 1 associates with ESRD in women with type 1 diabetes

Sandholm, N., McKnight, A. J., Salem, R. M., Brennan, E. P., Forsblom, C., Harjutsalo, V., Mäkinen, V. P., McKay, G. J., Sadlier, D. M., Williams, W. W., Martin, F., Panduru, N. M., Tarnow, L., Tuomilehto, J., Tryggvason, K., Zerbini, G., Comeau, M. E., Langefeld, C. D., Godson, C., Hirschhorn, J. N. & 3 othersMaxwell, A. P., Florez, J. C. & Groop, P. H., 1 Oct 2013, In : Journal of the American Society of Nephrology. 24, 10, p. 1537-1543 7 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Long-term leisure-time physical activity and serum metabolome

Kujala, U. M., Mäkinen, V. P., Heinonen, I., Soininen, P., Kangas, A. J., Leskinen, T. H., Rahkila, P., Würtz, P., Kovanen, V., Cheng, S., Sipilä, S., Hirvensalo, M., Telama, R., Tammelin, T., Savolainen, M. J., Pouta, A., O'Reilly, P. F., Mäntyselkä, P., Viikari, J., Kähönen, M. & 8 othersLehtimäki, T., Elliott, P., Vanhala, M. J., Raitakari, O. T., Järvelin, M. R., Kaprio, J., Kainulainen, H. & Ala-Korpela, M., 22 Jan 2013, In : Circulation. 127, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

440 Citations (Scopus)

The draft genome of sweet orange (Citrus sinensis)

Xu, Q., Chen, L. L., Ruan, X., Chen, D., Zhu, A., Chen, C., Bertrand, D., Jiao, W. B., Hao, B. H., Lyon, M. P., Chen, J., Gao, S., Xing, F., Lan, H., Chang, J. W., Ge, X., Lei, Y., Hu, Q., Miao, Y., Wang, L. & 19 othersXiao, S., Biswas, M. K., Zeng, W., Guo, F., Cao, H., Yang, X., Xu, X. W., Cheng, Y. J., Xu, J., Liu, J. H., Luo, O. J., Tang, Z., Guo, W. W., Kuang, H., Zhang, H. Y., Roose, M. L., Nagarajan, N., Deng, X. X. & Ruan, Y., 1 Jan 2013, In : Nature Genetics. 45, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Triglyceride-cholesterol imbalance across lipoprotein subclasses predicts diabetic kidney disease and mortality in type 1 diabetes: The FinnDiane Study

Mäkinen, V. P., Soininen, P., Kangas, A. J., Forsblom, C., Tolonen, N., Thorn, L. M., Viikari, J., Raitakari, O. T., Savolainen, M., Groop, P. H. & Ala-Korpela, M., 1 Apr 2013, In : Journal of Internal Medicine. 273, 4, p. 383-395 13 p.

Research output: Contribution to journalArticle

2012
24 Citations (Scopus)

Arterial stiffness and vascular complications in patients with type 1 diabetes: The finnish diabetic nephropathy (FinnDiane) study

Gordin, D., Wadén, J., Forsblom, C., Thorn, L. M., Rosengård-Bärlund, M., Heikkilä, O., Saraheimo, M., Tolonen, N., Hietala, K., Soro-Paavonen, A., Salovaara, L., Mäkinen, V. P., Peltola, T., Bernardi, L. & Groop, P. H., 1 Mar 2012, In : Annals of Medicine. 44, 2, p. 196-204 9 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Circulating metabolite predictors of glycemia in middle-aged men and women

Würtz, P., Tiainen, M., Makinen, V-P., Kangas, A. J., Soininen, P., Saltevo, J., Keinan̈en-Kiukaanniemi, S., Mäntyselkä, P., Lehtimak̈i, T., Laakso, M., Jula, A., Kähönen, M., Vanhala, M. & Ala-Korpela, M., 1 Aug 2012, In : Diabetes Care. 35, 8, p. 1749-1756 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)

van der Kloet, F. M., Tempels, F. W. A., Ismail, N., van der Heijden, R., Kasper, P. T., Rojas-Cherto, M., van Doorn, R., Spijksma, G., Koek, M., van der Greef, J., Makinen, V-P., Forsblom, C., Holthöfer, H., Groop, P. H., Reijmers, T. H. & Hankemeier, T., 1 Feb 2012, In : Metabolomics. 8, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons

Yao, F., Ariyaratne, P. N., Hillmer, A. M., Lee, W. H., Li, G., Teo, A. S. M., Woo, X. Y., Zhang, Z., Chen, J. P., Poh, W. T., Zawack, K. F. B., Chan, C. S., Leong, S. T., Neo, S. C., Choi, P. S. D., Gao, S., Nagarajan, N., Thoreau, H., Shahab, A., Ruan, X. & 6 othersCacheux-Rataboul, V., Wei, C. L., Bourque, G., Sung, W. K., Liu, E. T. & Ruan, Y., 28 Sep 2012, In : PloS one. 7, 9, e46152.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Metabolic diversity of progressive kidney disease in 325 patients with type 1 diabetes (the FinnDiane Study)

Mäkinen, V. P., Tynkkynen, T., Soininen, P., Peltola, T., Kangas, A. J., Forsblom, C., Thorn, L. M., Kaski, K., Laatikainen, R., Ala-Korpela, M. & Groop, P. H., 2 Mar 2012, In : Journal of Proteome Research. 11, 3, p. 1782-1790 9 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes

Sandholm, N., Salem, R. M., McKnight, A. J., Brennan, E. P., Forsblom, C., Isakova, T., McKay, G. J., Williams, W. W., Sadlier, D. M., Mäkinen, V. P., Swan, E. J., Palmer, C., Boright, A. P., Ahlqvist, E., Deshmukh, H. A., Keller, B. J., Huang, H., Ahola, A. J., Fagerholm, E., Gordin, D. & 73 othersHarjutsalo, V., He, B., Heikkilä, O., Hietala, K., Kytö, J., Lahermo, P., Lehto, M., Lithovius, R., Österholm, A. M., Parkkonen, M., Pitkäniemi, J., Rosengård-Bärlund, M., Saraheimo, M., Sarti, C., Söderlund, J., Soro-Paavonen, A., Syreeni, A., Thorn, L. M., Tikkanen, H., Tolonen, N., Tryggvason, K., Tuomilehto, J., Wadén, J., Gill, G. V., Prior, S., Guiducci, C., Mirel, D. B., Taylor, A., Hosseini, S. M., Parving, H. H., Rossing, P., Tarnow, L., Ladenvall, C., Alhenc-Gelas, F., Lefebvre, P., Rigalleau, V., Roussel, R., Tregouet, D. A., Maestroni, A., Maestroni, S., Falhammar, H., Gu, T., Möllsten, A., Cimponeriu, D., Ioana, M., Mota, M., Mota, E., Serafinceanu, C., Stavarachi, M., Hanson, R. L., Nelson, R. G., Kretzler, M., Colhoun, H. M., Panduru, N. M., Gu, H. F., Brismar, K., Zerbini, G., Hadjadj, S., Marre, M., Groop, L., Lajer, M., Bull, S. B., Waggott, D., Paterson, A. D., Savage, D. A., Bain, S. C., Martin, F., Hirschhorn, J. N., Godson, C., Florez, J. C., Groop, P. H., Maxwell, A. P. & Böger, C. A., 1 Sep 2012, In : PLoS genetics. 8, 9, e1002921.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Sphingomyelin is associated with kidney disease in type 1 diabetes (The FinnDiane Study)

Makinen, V-P., Tynkkynen, T., Soininen, P., Forsblom, C., Peltola, T., Kangas, A. J., Groop, P. H. & Ala-Korpela, M., 1 Jun 2012, In : Metabolomics. 8, 3, p. 369-375 7 p.

Research output: Contribution to journalArticle

2011
62 Citations (Scopus)

Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes

Hillmer, A. M., Yao, F., Inaki, K., Lee, W. H., Ariyaratne, P. N., Teo, A. S. M., Woo, X. Y., Zhang, Z., Zhao, H., Ukil, L., Chen, J. P., Zhu, F., So, J. B. Y., Salto-Tellez, M., Poh, W. T., Zawack, K. F. B., Nagarajan, N., Gao, S., Li, G., Kumar, V. & 19 othersLim, H. P. J., Sia, Y. Y., Chan, C. S., Leong, S. T., Neo, S. C., Choi, P. S. D., Thoreau, H., Tan, P. B. O., Shahab, A., Ruan, X., Bergh, J., Hall, P., Cacheux-Rataboul, V., Wei, C. L., Yeoh, K. G., Sung, W. K., Bourque, G., Liu, E. T. & Ruan, Y., 1 May 2011, In : Genome Research. 21, 5, p. 665-675 11 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

Opera: Reconstructing optimal genomic scaffolds with high-throughput paired-end sequences

Gao, S., Sung, W. K. & Nagarajan, N., 1 Nov 2011, In : Journal of Computational Biology. 18, 11, p. 1681-1691 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

Bernardi, L., Rosengård-Bärlund, M., Sandelin, A., Makinen, V-P., Forsblom, C. & Groop, P. H., 1 Aug 2011, In : Diabetologia. 54, 8, p. 2164-2173 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Soluble receptor for AGE (RAGE) is a novel independent predictor of all-cause and cardiovascular mortality in type 1 diabetes

Thomas, M. C., Söderlund, J., Lehto, M., Mäkinen, V. P., Moran, J. L., Cooper, M. E., Forsblom, C. & Groop, P. H., 1 Oct 2011, In : Diabetologia. 54, 10, p. 2669-2677 9 p.

Research output: Contribution to journalArticle

2009
17 Citations (Scopus)

Higher-order genome organization in platypus and chicken sperm and repositioning of sex chromosomes during mammalian evolution

Tsend-Ayush, E., Dodge, N., Mohr, J., Casey, A., Himmelbauer, H., Kremitzki, C. L., Schatzkamer, K., Graves, T., Warren, W. C. & Griützner, F., 1 Jan 2009, In : Chromosoma. 118, 1, p. 53-69 17 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

Tolonen, N., Forsblom, C., Thorn, L., Wadén, J., Rosengård-Bärlund, M., Saraheimo, M., Feodoroff, M., Makinen, V-P., Gordin, D., Taskinen, M. R. & Groop, P. H., 1 Dec 2009, In : Diabetologia. 52, 12, p. 2522-2530 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study)

Mäkinen, V. P., Forsblom, C., Thorn, L. M., Wadén, J., Kaski, K., Ala-Korpela, M. & Groop, P. H., 6 Oct 2009, In : Cardiovascular Diabetology. 8, 1 p., 1475.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Platypus chain reaction: Directional and ordered meiotic pairing of the multiple sex chromosome chain in Ornithorhynchus anatinus

Daish, T., Casey, A. & Grützner, F., 1 Dec 2009, In : Reproduction, Fertility and Development. 21, 8, p. 976-984 9 p.

Research output: Contribution to journalArticle

349 Citations (Scopus)

The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes

Groop, P. H., Thomas, M. C., Moran, J. L., Wadèn, J., Thorn, L. M., Mäkinen, V. P., Rosengård-Bärlund, M., Saraheimo, M., Hietala, K., Heikkilä, O. & Forsblom, C., 1 Jan 2009, In : Diabetes. 58, 7, p. 1651-1658 8 p.

Research output: Contribution to journalArticle

2005
23 Citations (Scopus)

Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy

Fröjdö, S., Sjölind, L., Parkkonen, M., Mäkinen, V. P., Kilpikari, R., Pettersson-Fernholm, K., Forsblom, C., Fagerudd, J., Tikellis, C., Cooper, M. E., Wessman, M. & Groop, P. H., 1 Nov 2005, In : Diabetologia. 48, 11, p. 2278-2281 4 p.

Research output: Contribution to journalArticle