Research Output 1985 2019

2019

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

Prowse, T. A., Adikusuma, F., Cassey, P., Thomas, P. & Ross, J. V., 1 Feb 2019, In : eLife. 8, e41873.

Research output: Contribution to journalArticle

Differential response to injury in fetal and adolescent sheep hearts in the immediate post in the immediate post-myocardial myocardial myocardial infarction period

Lock, M. C., Darby, J. R. T., Soo, J. Y., Brooks, D. A., Perumal, R., Selvanayagam, J., Seed, M., MacGowan, C. K., Porrello, E. R., Tellam, R. L. & Morrison, J. L., 1 Mar 2019, In : Frontiers in Physiology. 10, MAR, 208.

Research output: Contribution to journalArticle

Early disease course is unaltered in mucopolysaccharidosis type IIIA (MPS IIIA) mice lacking α-synuclein

Soe, K., Beard, H., Neumann, D., Trim, P., Duplock, S., Snel, M., Hopwood, J. & Hemsley, K., 1 Jan 2019, In : Neuropathology and Applied Neurobiology.

Research output: Contribution to journalArticle

Efficacy of a synthetic calcium phosphate with submicron surface topography as autograft extender in lapine posterolateral spinal fusion

van Dijk, L. A., Barbieri, D., Barrère-de Groot, F., Yuan, H., Oliver, R., Christou, C., Walsh, W. R. & de Bruijn, J. D., 1 Aug 2019, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 107, 6, p. 2080-2090 11 p.

Research output: Contribution to journalArticle

Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model

Oliver, R. A., Lovric, V., Christou, C. & Walsh, W. R., 1 Jul 2019, In : Journal of Biomaterials Applications. 34, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

Fetal Hepatic Flow in Sheep Assessed using 4D flow MRI

Schrauben, E., Saini, B., Darby, J. R., Holman, S., Yin Soon, J., Lock, M. C., Perumal, S. R., Seed, M. & Morrison, J. L., 15 Feb 2019, (Submitted).

Research output: Contribution to conferenceAbstract

Immuno-PET of innate immune markers CD11b and IL-1b detects inflammation in murine colitis

Dmochowska, N., Tieu, W., Keller, M. D., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P., 1 Jun 2019, In : Journal of Nuclear Medicine. 60, 6, p. 858-863 6 p.

Research output: Contribution to journalArticle

PNEUMATOCELES AS A MARKER OF CHEST TRAUMA IN POST-MORTEM CT SCANS

Langlois, N., Perumal, R. & Sebben, R., 4 Feb 2019, (Submitted).

Research output: Contribution to conferencePoster

Synthetic disaccharide standards enable quantitative analysis of stored heparan sulfate in MPS IIIA murine brain regions

He, Q. Q., Trim, P. J., Lau, A. A., King, B. M., Hopwood, J. J., Hemsley, K. M., Snel, M. F. & Ferro, V., 2 Jul 2019, In : ACS chemical neuroscience.

Research output: Contribution to journalArticle

2018

18-kDa translocator protein radioligand [18F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury

O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C., 2018.

Research output: Contribution to conferencePoster

1 Citation (Scopus)

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Wang, D., Zhong, L., Li, M., Li, J., Tran, K., Ren, L., He, R., Xie, J., Moser, R. P., Fraser, C., Kuchel, T., Sena-Esteves, M., Flotte, T. R., Aronin, N. & Gao, G., 14 Dec 2018, In : Molecular Therapy - Methods and Clinical Development. 11, p. 65-72 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Application of Calcium Sulfate for Dead Space Management in Soft Tissue: Characterisation of a Novel in Vivo Response

Oliver, R. A., Lovric, V., Christou, C., Aiken, S. S., Cooper, J. J. & Walsh, W. R., 2018, In : BioMed Research International. 2018, 8065141.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease

Pfister, E. L., Dinardo, N., Mondo, E., Borel, F., Conroy, F., Fraser, C., Gernoux, G., Han, X., Hu, D., Johnson, E., Kennington, L., Liu, P., Reid, S. J., Sapp, E., Vodicka, P., Kuchel, T., Morton, A. J., Howland, D., Moser, R., Sena-Esteves, M. & 4 othersGao, G., Mueller, C., Difiglia, M. & Aronin, N., 1 Jun 2018, In : Human Gene Therapy. 29, 6, p. 663-673 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Cell banking for regulatory T cell-based therapy: Strategies to overcome the impact of cryopreservation on the Treg viability and phenotype

Gołab, K., Grose, R., Placencia, V., Wickrema, A., Solomina, J., Tibudan, M., Konsur, E., Ciepły, K., Marek-Trzonkowska, N., Trzonkowski, P., Millis, J. M., Fung, J. & Witkowski, P., 1 Jan 2018, In : Oncotarget. 9, 11, p. 9728-9740 13 p.

Research output: Contribution to journalArticle

Correction: Gestational dietary protein is associated with sex specific decrease in blood flow, fetal heart growth and postnatal blood pressure of progeny (PLoS ONE (2015) 10:4 (e0125694) DOI: 10.1371/journal.pone.0125694)

Hernandez-Medrano, J. H., Copping, K. J., Hoare, A., Wapanaar, W., Grivell, R., Kuchel, T., Miguel-Pacheco, G., Caroline McMillen, I., Rodgers, R. J. & Perry, V. E. A., 1 May 2018, In : PLoS ONE. 13, 5, e0197942.

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

Tong, W. Y., Alnakhli, M., Bhardwaj, R., Apostolou, S., Sinha, S., Fraser, C., Kuchel, T., Kuss, B. & Voelcker, N. H., 13 Apr 2018, In : Journal of Nanobiotechnology. 16, 1, 38.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of disease lesions in the developing canine MPS IIIA brain

Winner, L. K., Marshall, N. R., Jolly, R. D., Trim, P. J., Duplock, S. K., Snel, M. F. & Hemsley, K. M., 20 Jun 2018, JIMD Reports. Springer, p. 91-101 11 p. (JIMD Reports; vol. 43).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fetal Hepatic Flow in Sheep Assessed using 4D flow MRI

Schrauben, E., Saini, B., Darby, J. R. T., Holman, S., Yin Soon, J., Perumal, S. R., Lock, M. C., Seed, M. & Macgowan, C., 8 Nov 2018.

Research output: Contribution to conferenceAbstract

Open Access
8 Citations (Scopus)

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

MacGregor, S., Ong, J-S., An, J., Han, X., Zhou, T., Siggs, O. M., Law, M. H., Souzeau, E., Sharma, S., Lynn, D. J., Beesley, J., Sheldrick, B., Mills, R. A., Landers, J., Ruddle, J. B., Graham, S. L., Healey, P. R., White, A. J. R., Casson, R. J., Best, S. & 12 othersGrigg, J. R., Goldberg, I., Powell, J. E., Whiteman, D. C., Radford-Smith, G. L., Martin, N. G., Montgomery, G. W., Burdon, K. P., Mackey, D. A., Gharahkhani, P., Craig, J. E. & Hewitt, A. W., 2018, In : Nature Genetics. 50, 8, p. 1067-1071 5 p.

Research output: Contribution to journalArticle

Immuno-PET of innate immune markers CD11b and 1IL-1β detect inflammation in murine colitis.

Dmochowska, N., Tieu, W., Keller, M., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P., 2018, In : Journal of Nuclear Medicine. JNUMED/2018/219287.

Research output: Contribution to journalArticle

In vivo PET of innate immune responses in murine DSS colitis

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H. R., Keller, M., Tieu, W. & Hughes, P., 2018.

Research output: Contribution to conferencePoster

Ion Mobility Separation Mass Spectrometry Imaging

Snel, M. F., 2018, (Accepted/In press) In : Comprehensive Analytical Chemistry.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Large deletions induced by Cas9 cleavage

Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T. & Thomas, P., 9 Aug 2018, In : Nature. 560, 7717, p. E8-E9

Research output: Contribution to journalArticle

Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

Hassiotis, S., Manavis, J., Blumbergs, P. C., Hattersley, K. J., Carosi, J. M., Kamei, M. & Sargeant, T., 1 May 2018, In : European Journal of Neuroscience. 47, 9, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lysosomal N-acetyltransferase interacts with ALIX and is detected in extracellular vesicles

Fedele, A. O., Isenmann, S., Kamei, M., Snel, M., Trim, P., Proud, C. & Hopwood, J., 1 Oct 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 10, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

Martin, S. K., Fitter, S., El Khawanky, N., Grose, R., Walkley, C. R., Purton, L. E., Ruegg, M. A., Hall, M. N., Gronthos, S. & Zannettino, A., 1 Dec 2018, In : Scientific Reports. 8, 1, 14501.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Neuronal-specific impairment of heparan sulfate degradation in Drosophila reveals pathogenic mechanisms for Mucopolysaccharidosis type IIIA

Webber, D. L., Choo, A., Hewson, L. J., Trim, P. J., Snel, M. F., Hopwood, J. J., Richards, R. I., Hemsley, K. M. & O'Keefe, L. V., 1 May 2018, In : Experimental Neurology. 303, p. 38-47 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice

Masedunskas, A., Appaduray, M. A., Lucas, C. A., Cagigas, M. L., Heydecker, M., Holliday, M., Meiring, J. C. M., Hook, J., Kee, A., White, M., Thomas, P., Zhang, Y., Adelstein, R. S., Meckel, T., Böcking, T., Weigert, R., Bryce, N. S., Gunning, P. W. & Hardeman, E. C., 1 Mar 2018, In : Journal of Cell Science. 131, 6, jcs212654.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy

Homan, C. C., Pederson, S., To, T. H., Tan, C., Piltz, S., Corbett, M. A., Wolvetang, E., Thomas, P. Q., Jolly, L. A. & Gecz, J., 1 Aug 2018, In : Neurobiology of Disease. 116, p. 106-119 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The in vivo response to a novel Ti coating compared with polyether ether ketone: evaluation of the periphery and inner surfaces of an implant

Walsh, W. R., Pelletier, M. H., Christou, C., He, J., Vizesi, F. & Boden, S. D., 2018, (Accepted/In press) In : Spine Journal. 18, 7, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

2017

18F-FDG-PET: A non-invasive tool for imaging colitis: Australasian Society for Immunology Annual Scientific Meeting

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H., Keller, M., Tieu, W. & Hughes, D. P., Nov 2017.

Research output: Contribution to conferencePoster

18F-FDG-PET: A non-invasive tool for imaging colitis

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H. R., Keller, M., Tieu, W. & Hughes, P., 2017.

Research output: Contribution to conferencePoster

18F-FDG-PET: A non-invasive tool for imaging colitis

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H. R., Keller, M., Tieu, W. & Hughes, P., 2017.

Research output: Contribution to conferencePoster

2 Citations (Scopus)

A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome

Lau, A. A., King, B. M., Thorsen, C. L., Hassiotis, S., Beard, H., Trim, P. J., Whyte, L. S., Tamang, S. J., Duplock, S. K., Snel, M. F., Hopwood, J. J. & Hemsley, K. M., 27 Apr 2017, (Accepted/In press) In : Journal of Inherited Metabolic Disease. 40, 5, p. 1-10 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A novel method of suspending sheep for clinical research

Christou, C. & Walsh, W. R., 1 Dec 2017, In : Laboratory Animals. 51, 6, p. 652-655 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Atubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development

Diggle, C. P., Martinez-Garay, I., Molnar, Z., Brinkworth, M. H., White, E., Fowler, E., Hughes, R., Hayward, B. E., Carr, I. M., Watson, C. M., Crinnion, L., Asipu, A., Woodman, B., Coletta, P. L., Markham, A. F., Dear, T. N., Bonthron, D. T., Peckham, M., Morrison, E. E. & Sheridan, E., 1 Apr 2017, In : PLoS ONE. 12, 4, e0174264.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Biomechanical comparison of pin and nitinol bone staple fixation to pin and tension band wire fixation for the stabilization of canine olecranon osteotomies

Lai, A., Christou, C., Bailey, C., Tan, C. J., Culvenor, J., Wang, T. & Walsh, W. R., 2017, In : Veterinary and Comparative Orthopaedics and Traumatology. 30, 5, p. 324-330 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity

Wilson, C. H., Nikolic, A., Kentish, S. J., Keller, M., Hatzinikolas, G., Dorstyn, L., Page, A. J. & Kumar, S., 26 Oct 2017, In : Cell death & disease. 8, 10, p. e3136

Research output: Contribution to journalArticle

20 Citations (Scopus)

Caspase-2-mediated cell death is required for deleting aneuploid cells

Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D. R., Dorstyn, L. & Kumar, S., 11 May 2017, In : Oncogene. 36, 19, p. 2704-2714 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Critical size bone defect healing using collagen-calcium phosphate bone graft materials

Walsh, W. R., Oliver, R. A., Christou, C., Lovric, V., Walsh, E. R., Prado, G. R. & Haider, T., 1 Jan 2017, In : PLoS ONE. 12, 1, e0168883.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of relative bioaccessibility leaching procedure for an assessment of lead bioavailability in mixed metal contaminated soils

Wijayawardena, M. A. A., Naidu, R., Megharaj, M., Lamb, D., Thavamani, P. & Kuchel, T., 1 Apr 2017, In : Environmental Technology and Innovation. 7, p. 229-238 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging

Duan, A. Q., Lock, M. C., Perumal, S. R., Darby, J. R., Soo, J. Y., Selvanayagam, J. B., Macgowan, C. K., Seed, M. & Morrison, J. L., 13 Sep 2017, In : Journal of Cardiovascular Magnetic Resonance. 19, 1, 69.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Functional equivalence of the SOX2 and SOX3 transcription factors in the developing mouse brain and testes

Adikusuma, F., Pederick, D., McAninch, D., Hughes, J. & Thomas, P., 1 Jul 2017, In : Genetics. 206, 3, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

Genetic analysis of barley for Shochu quality

Sadohara, R., Iwami, A., Kajiwara, Y., Takashita, H., March, T. J., Coventry, S. J., Box, A. J., Degner, S. & Eglinton, J. K., 1 Mar 2017, In : Journal of Cereal Science. 74, p. 174-182 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Inbred Mouse Populations Exhibit Intergenerational Changes in Intestinal Microbiota Composition and Function Following Introduction to a Facility

Choo, J. M., Trim, P. J., Leong, L. E. X., Abell, G. C. J., Brune, C., Jeffries, N., Wesselingh, S., Dear, T. N., Snel, M. F. & Rogers, G. B., 2017, In : Frontiers in Microbiology. 8, p. 608

Research output: Contribution to journalArticle

8 Citations (Scopus)

Influence of co-contaminant exposure on the absorption of arsenic, cadmium and lead

Ollson, C. J., Smith, E., Herde, P. & Juhasz, A. L., 1 Jan 2017, In : Chemosphere. 168, p. 658-666 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Influence of sample matrix on the bioavailability of arsenic, cadmium and lead during co-contaminant exposure

Ollson, C. J., Smith, E., Herde, P. & Juhasz, A. L., 1 Oct 2017, In : Science of the Total Environment. 595, p. 660-665 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling

Hughes, J., Dawson, R., Tea, M., McAninch, D., Piltz, S., Jackson, D., Stewart, L., Ricos, M. G., Dibbens, L. M., Harvey, N. L. & Thomas, P., 1 Dec 2017, In : Scientific Reports. 7, 1, 12618.

Research output: Contribution to journalArticle