Research Output 1980 2020

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2020

Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

Morton, A. J., Middleton, B., Rudiger, S., Bawden, C. S., Kuchel, T. & Skene, D. J., 1 Mar 2020, In : Journal of Pineal Research. 68, 2, e12624.

Research output: Contribution to journalArticle

2019

Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissues

Darby, J. R. T., Sorvina, A., Bader, C. A., Lock, M. C., Soo, J. Y., Holman, S. L., Seed, M., Kuchel, T., Brooks, D. A., Plush, S. E. & Morrison, J. L., 1 Jan 2019, In : Journal of Biophotonics. e201960085.

Research output: Contribution to journalArticle

Differential response to injury in fetal and adolescent sheep hearts in the immediate post in the immediate post-myocardial myocardial myocardial infarction period

Lock, M. C., Darby, J. R. T., Soo, J. Y., Brooks, D. A., Perumal, R., Selvanayagam, J., Seed, M., MacGowan, C. K., Porrello, E. R., Tellam, R. L. & Morrison, J. L., 5 Mar 2019, In : Frontiers in Physiology. 10, MAR, p. 208 208.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Efficacy of a synthetic calcium phosphate with submicron surface topography as autograft extender in lapine posterolateral spinal fusion

van Dijk, L. A., Barbieri, D., Barrère-de Groot, F., Yuan, H., Oliver, R., Christou, C., Walsh, W. R. & de Bruijn, J. D., 1 Aug 2019, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 107, 6, p. 2080-2090 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus

Duan, A. Q., Darby, J. R. T., Soo, J. Y., Lock, M. C., Zhu, M. Y., Flynn, L. V., Perumal, R., Macgowan, C. K., Selvanayagam, J., Morrison, J. L. & Seed, M., 1 Dec 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 317, 6, p. R780-R792

Research output: Contribution to journalArticle

High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support

Stevens, N. E., Nash, C. H., Fraser, C. K., Kuchel, T. R., Maiden, M. J., Chapman, M. J., Diener, K. R. & Hayball, J. D., 30 Aug 2019, In : Experimental and therapeutic medicine. 18, 5, p. 3271-3280 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Immuno-PET of innate immune markers CD11b and IL-1b detects inflammation in murine colitis

Dmochowska, N., Tieu, W., Keller, M. D., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P., 1 Jun 2019, In : Journal of Nuclear Medicine. 60, 6, p. 858-863 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

In Vitro, in Vivo, and Spectroscopic Assessment of Lead Exposure Reduction via Ingestion and Inhalation Pathways Using Phosphate and Iron Amendments

Kastury, F., Smith, E., Doelsch, E., Lombi, E., Donnelley, M., Cmielewski, P. L., Parsons, D. W., Scheckel, K. G., Paterson, D., De Jonge, M. D., Herde, C. & Juhasz, A. L., 29 Jul 2019, In : Environmental Science and Technology.

Research output: Contribution to journalArticle

Neurological Examination of Sheep (Ovis aries) with Unilateral and Bilateral Quinolinic Acid Lesions of the Striatum Assessed by Magnetic Resonance Imaging

O’Connell, A., Sinnott, B., Kuchel, T. R., Perumal, S. R., Fraser, C. K., Hemsley, K. M. & Morton, A. J., 6 Aug 2019, In : Journal of Neurology and Experimental Neuroscience. 05, 02

Research output: Contribution to journalArticle

2018
5 Citations (Scopus)

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Wang, D., Zhong, L., Li, M., Li, J., Tran, K., Ren, L., He, R., Xie, J., Moser, R. P., Fraser, C., Kuchel, T., Sena-Esteves, M., Flotte, T. R., Aronin, N. & Gao, G., 14 Dec 2018, In : Molecular Therapy - Methods and Clinical Development. 11, p. 65-72 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Application of Calcium Sulfate for Dead Space Management in Soft Tissue: Characterisation of a Novel in Vivo Response

Oliver, R. A., Lovric, V., Christou, C., Aiken, S. S., Cooper, J. J. & Walsh, W. R., 2018, In : BioMed Research International. 2018, 8065141.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease

Pfister, E. L., Dinardo, N., Mondo, E., Borel, F., Conroy, F., Fraser, C., Gernoux, G., Han, X., Hu, D., Johnson, E., Kennington, L., Liu, P., Reid, S. J., Sapp, E., Vodicka, P., Kuchel, T., Morton, A. J., Howland, D., Moser, R., Sena-Esteves, M. & 4 othersGao, G., Mueller, C., Difiglia, M. & Aronin, N., 1 Jun 2018, In : Human Gene Therapy. 29, 6, p. 663-673 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

Tong, W. Y., Alnakhli, M., Bhardwaj, R., Apostolou, S., Sinha, S., Fraser, C., Kuchel, T., Kuss, B. & Voelcker, N. H., 13 Apr 2018, In : Journal of Nanobiotechnology. 16, 1, 38.

Research output: Contribution to journalArticle

Immuno-PET of innate immune markers CD11b and 1IL-1β detect inflammation in murine colitis.

Dmochowska, N., Tieu, W., Keller, M., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P., 2018, In : Journal of Nuclear Medicine. JNUMED/2018/219287.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The in vivo response to a novel Ti coating compared with polyether ether ketone: evaluation of the periphery and inner surfaces of an implant

Walsh, W. R., Pelletier, M. H., Christou, C., He, J., Vizesi, F. & Boden, S. D., 2018, (Accepted/In press) In : Spine Journal. 18, 7, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

2017
1 Citation (Scopus)

A novel method of suspending sheep for clinical research

Christou, C. & Walsh, W. R., 1 Dec 2017, In : Laboratory Animals. 51, 6, p. 652-655 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Biomechanical comparison of pin and nitinol bone staple fixation to pin and tension band wire fixation for the stabilization of canine olecranon osteotomies

Lai, A., Christou, C., Bailey, C., Tan, C. J., Culvenor, J., Wang, T. & Walsh, W. R., 2017, In : Veterinary and Comparative Orthopaedics and Traumatology. 30, 5, p. 324-330 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity

Wilson, C. H., Nikolic, A., Kentish, S. J., Keller, M., Hatzinikolas, G., Dorstyn, L., Page, A. J. & Kumar, S., 26 Oct 2017, In : Cell death & disease. 8, 10, p. e3136

Research output: Contribution to journalArticle

10 Citations (Scopus)

Critical size bone defect healing using collagen-calcium phosphate bone graft materials

Walsh, W. R., Oliver, R. A., Christou, C., Lovric, V., Walsh, E. R., Prado, G. R. & Haider, T., 1 Jan 2017, In : PLoS ONE. 12, 1, e0168883.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of relative bioaccessibility leaching procedure for an assessment of lead bioavailability in mixed metal contaminated soils

Wijayawardena, M. A. A., Naidu, R., Megharaj, M., Lamb, D., Thavamani, P. & Kuchel, T., 1 Apr 2017, In : Environmental Technology and Innovation. 7, p. 229-238 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging

Duan, A. Q., Lock, M. C., Perumal, S. R., Darby, J. R., Soo, J. Y., Selvanayagam, J. B., Macgowan, C. K., Seed, M. & Morrison, J. L., 13 Sep 2017, In : Journal of Cardiovascular Magnetic Resonance. 19, 1, 69.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Influence of co-contaminant exposure on the absorption of arsenic, cadmium and lead

Ollson, C. J., Smith, E., Herde, P. & Juhasz, A. L., 1 Jan 2017, In : Chemosphere. 168, p. 658-666 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Influence of sample matrix on the bioavailability of arsenic, cadmium and lead during co-contaminant exposure

Ollson, C. J., Smith, E., Herde, P. & Juhasz, A. L., 1 Oct 2017, In : Science of the Total Environment. 595, p. 660-665 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart

Morrison, J. L., Sorvina, A., Darby, J. R. T., Bader, C. A., Lock, M. C., Seed, M., Kuchel, T., Plush, S. E. & Brooks, D. A., 23 Oct 2017, In : Journal of Biophotonics.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers

Skene, D. J., Middleton, B., Fraser, C., Pennings, J. L. A., Kuchel, T., Rudiger, S. R., Bawden, C. S. & Morton, A. J., 22 Feb 2017, In : Scientific Reports. 7, 43030.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

Stevens, N. E., Chapman, M. J., Fraser, C., Kuchel, T., Hayball, J. D. & Diener, K. R., 1 Dec 2017, In : Scientific Reports. 7, 1, 5850.

Research output: Contribution to journalArticle

3 Citations (Scopus)
13 Citations (Scopus)

Variation in arsenic bioavailability in rice genotypes using swine model: An animal study

Islam, S., Rahman, M. M., Duan, L., Islam, M. R., Kuchel, T. & Naidu, R., 1 Dec 2017, In : Science of the Total Environment. 599-600, p. 324-331 8 p.

Research output: Contribution to journalArticle

2016
2 Citations (Scopus)

A synthetic olfactory agonist reduces aggression when sows are mixed into small groups

Plush, K., Hughes, P., Herde, P. & van Wettere, W., 1 Dec 2016, In : Applied Animal Behaviour Science. 185, p. 45-51 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Biomechanical evaluation of shape-memory alloy staples for internal fixation—an in vitro study

Hoon, Q. C. J., Pelletier, M. H., Christou, C., Johnson, K. A. & Walsh, W. R., 1 Dec 2016, In : Journal of Experimental Orthopaedics. 3, 1, 19.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Comparison of oral bioavailability of benzo[a]pyrene in soils using rat and swine and the implications for human health risk assessment

Duan, L., Naidu, R., Liu, Y., Dong, Z., Mallavarapu, M., Herde, P., Kuchel, T. & Semple, K. T., 1 Sep 2016, In : Environment International. 94, p. 95-102 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Does PEEK/HA Enhance Bone Formation Compared With PEEK in a Sheep Cervical Fusion Model?

Walsh, W. R., Pelletier, M. H., Bertollo, N., Christou, C. & Tan, C., 1 Nov 2016, In : Clinical Orthopaedics and Related Research. 474, 11, p. 2364-2372 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Glycosphingolipid analysis in a naturally occurring ovine model of acute neuronopathic Gaucher disease

Karageorgos, L., Hein, L., Rozaklis, T., Adams, M., Duplock, S., Snel, M., Hemsley, K., Kuchel, T., Smith, N. & Hopwood, J. J., 1 Jul 2016, In : Neurobiology of Disease. 91, p. 143-154 12 p.

Research output: Contribution to journalArticle

NIF Networking Fellows Workshop, Research Imaging Snapshot

Keller, M. & Salehi, S., 2016, In : NIF Newsletter. 4, p. 11 1 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Possible isoflurane effect observed in isotope ratio mass spectrometry from a large animal model

Matthews, T., Trochsler, M., Barry, S., Kuchel, T., Zacharakis, B. & Maddern, G., 25 Sep 2016, In : Journal of Experimental and Applied Animal Sciences. 2, 2314-5692, p. 71-79

Research output: Contribution to journalArticle

5 Citations (Scopus)

Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection

Stevens, N. E., Hatjopolous, A., Fraser, C. K., Alsharifi, M., Diener, K. R. & Hayball, J. D., 6 Jul 2016, In : Scientific Reports. 6, 29154.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Structure and function of the kidney in septic shock: A prospective controlled experimental study

Maiden, M. J., Otto, S., Brealey, J. K., Finnis, M. E., Chapman, M. J., Kuchel, T. R., Nash, C. H., Edwards, J. & Bellomo, R., 15 Sep 2016, In : American journal of respiratory and critical care medicine. 194, 6, p. 692-700 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Towards a subcutaneous optical biosensor based on thermally hydrocarbonised porous silicon

Tong, W. Y., Sweetman, M. J., Marzouk, E. R., Fraser, C., Kuchel, T. & Voelcker, N. H., 1 Jan 2016, In : Biomaterials. 74, p. 217-230 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Triiodothyronine administration in a model of septic shock: A randomized blinded placebo-controlled trial

Maiden, M. J., Chapman, M. J., Torpy, D. J., Kuchel, T. R., Clarke, I. J., Nash, C. H., Fraser, J. D. & Ludbrook, G. L., 1 Jun 2016, In : Critical Care Medicine. 44, 6, p. 1153-1160 8 p.

Research output: Contribution to journalArticle

2015
3 Citations (Scopus)

A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine

Miller, D. S., Parsons, A. M., Bresland, J., Herde, P., Pham, D. M., Tan, A., Hsu, H. Y., Prestidge, C. A., Kuchel, T., Begg, R., Aziz, S. M. & Butler, R. N., 23 Jul 2015, In : Journal of Zhejiang University: Science B. 16, 7, p. 586-592 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

BRAF and MEK inhibition variably affect GD2-specific chimeric antigen receptor (CAR) T-cell function in vitro

Gargett, T., Fraser, C. K., Dotti, G., Yvon, E. S. & Brown, M. P., 14 Jan 2015, In : Journal of Immunotherapy. 38, 1, p. 12-23 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Development of a novel model for the assessment of dead-space management in soft tissue

Oliver, R. A., Lovric, V., Yu, Y., Christou, C., Aiken, S. S., Cooper, J. J. & Walsh, W. R., 25 Aug 2015, In : PLoS ONE. 10, 8, e0136514.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Gestational dietary protein is associated with sex specific decrease in blood flow, fetal heart growth and post-natal blood pressure of progeny

Hernandez-Medrano, J. H., Copping, K. J., Hoare, A., Wapanaar, W., Grivell, R., Kuchel, T., Miguel-Pacheco, G., McMillen, I. C., Rodgers, R. J. & Perry, V. E. A., 27 Apr 2015, In : PloS one. 10, 4, e0125694.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Plasma-sprayed titanium coating to polyetheretherketone improves the bone-implant interface

Walsh, W. R., Bertollo, N., Christou, C., Schaffner, D. & Mobbs, R. J., 1 May 2015, In : Spine Journal. 15, 5, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Predicting Arsenic Relative Bioavailability Using Multiple in Vitro Assays: Validation of in Vivo-in Vitro Correlations

Juhasz, A. L., Herde, P., Herde, C., Boland, J. & Smith, E., 15 Sep 2015, In : Environmental Science and Technology. 49, 18, p. 11167-11175 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Quantification of b-amyloidosis and rCBF with dedicated PET, 7 T MR imaging, and high-resolution microscopic MR imaging at 16.4 T in APP23 Mice

Maier, F. C., Keller, M., Bukala, D., Bender, B., Mannheim, J. G., Brereton, I. M., Galloway, G. J. & Pichler, B. J., 1 Jan 2015, In : Journal of Nuclear Medicine. 56, 10, p. 1593-1599 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Transdermal fentanyl and its use in ovine surgery

Christou, C., Oliver, R. A., Rawlinson, J. & Walsh, W. R., 1 Jun 2015, In : Research in Veterinary Science. 100, p. 252-256 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Using soil properties to predict in vivo bioavailability of lead in soils

Wijayawardena, M. A. A., Naidu, R., Megharaj, M., Lamb, D., Thavamani, P. & Kuchel, T., 1 Nov 2015, In : Chemosphere. 138, p. 422-428 7 p.

Research output: Contribution to journalArticle

2014
3 Citations (Scopus)

Comparative studies of the venom of a new taipan species, Oxyuranus temporalis, with other members of its genus

Barber, C. M., Madaras, F., Turnbull, R. K., Morley, T., Dunstan, N., Allen, L., Kuchel, T., Mirtschin, P. & Hodgson, W. C., 1 Jan 2014, In : Toxins. 6, 7, p. 1979-1995 17 p.

Research output: Contribution to journalArticle