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2020

Abstract P507: Interplay Between Diet and Gut Microbiota, and Circulating Levels of Trimethylamine N-oxide: Findings From the Men’s Lifestyle Validation Study

Li, J., Li, Y., Ivey, K., Wang, D., Wilkinson, J., Franke, A., Chan, A., Huttenhower, C., Hu, F. B., Rimm, E. & Sun, Q., 3 Mar 2020, In : Circulation. 141, Suppl_1

Research output: Contribution to journalArticle

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

Hin, N., Newman, M., Kaslin, J., Douek, A. M., Lumsden, A., Nik, S. H. M., Dong, Y., Zhou, X. F., Manucat-Tan, N. B., Ludington, A., Adelson, D. L., Pederson, S. & Lardelli, M., 24 Jan 2020, In : PloS one. 15, 1, e0227258.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ageing human bone marrow mesenchymal stem cells have depleted NAD(P)H and distinct multispectral autofluorescence

Campbell, J. M., Mahbub, S., Habibalahi, A., Paton, S., Gronthos, S. & Goldys, E., 1 Jan 2020, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalArticle

A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation

Khomtchouk, K. M., Kouhi, A., Xia, A., Bekale, L. A., Massa, S. M., Sweere, J. M., Pletzer, D., Hancock, R. E., Bollyky, P. L. & Santa Maria, P. L., Aug 2020, In : Science Advances. 6, 33, eabc1828.

Research output: Contribution to journalArticle

Open Access

A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, W., Qiu, J., Nassar, Z. D., Shaw, P. N., McMahon, K. A., Ferguson, C., Parton, R. G., Riggins, G. J., Harris, J. M. & Parat, M. O., 1 Mar 2020, In : Journal of Cellular and Molecular Medicine. 24, 6, p. 3724-3738 15 p.

Research output: Contribution to journalArticle

Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer

Miladinovic, D., Cusick, T., Mahon, K. L., Haynes, A. M., Cortie, C. H., Meyer, B. J., Stricker, P. D., Wittert, G. A., Butler, L. M., Horvath, L. G. & Hoy, A. J., Jun 2020, In : Cancers. 12, 6, 1385.

Research output: Contribution to journalArticle

Open Access

Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men

Nguyen, L. H., Ma, W., Wang, D. D., Cao, Y., Mallick, H., Gerbaba, T. K., Lloyd-Price, J., Abu-Ali, G., Hall, A. B., Sikavi, D., Drew, D. A., Mehta, R. S., Arze, C., Joshi, A. D., Yan, Y., Branck, T., DuLong, C., Ivey, K. L., Ogino, S., Rimm, E. B. & 5 others, Song, M., Garrett, W. S., Izard, J., Huttenhower, C. & Chan, A. T., 20 Jan 2020, In : Gastroenterology.

Research output: Contribution to journalArticle

Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men

Nguyen, L. H., Ma, W., Wang, D. D., Cao, Y., Mallick, H., Gerbaba, T. K., Lloyd-Price, J., Abu-Ali, G., Hall, A. B., Sikavi, D., Drew, D. A., Mehta, R. S., Arze, C., Joshi, A. D., Yan, Y., Branck, T., DuLong, C., Ivey, K. L., Ogino, S., Rimm, E. B. & 5 others, Song, M., Garrett, W. S., Izard, J., Huttenhower, C. & Chan, A. T., Apr 2020, In : Gastroenterology. 158, 5, p. 1313-1325 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice

Haifer, C., Kelly, C. R., Paramsothy, S., Andresen, D., Papanicolas, L. E., McKew, G. L., Borody, T. J., Kamm, M., Costello, S. P., Andrews, J. M., Begun, J., Chan, H. T., Connor, S., Ghaly, S., Johnson, P. D. R., Lemberg, D. A., Paramsothy, R., Redmond, A., Sheorey, H., Van Der Poorten, D. & 1 others, Leong, R. W., 1 May 2020, In : Gut. 69, 5, p. 801-810 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Bacterial Aggregation Triggered by Fibril Forming Tryptophan-Rich Sequences: Effects of Peptide Side Chain and Membrane Phospholipids

Bagheri, M., Nikolenko, H., Arasteh, S., Rezaei, N., Behzadi, M., Dathe, M. & Hancock, R. E. W., 17 Jun 2020, In : ACS Applied Materials and Interfaces. 12, 24, p. 26852-26867 16 p.

Research output: Contribution to journalArticle

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

The EPIC Consortium*, 6 May 2020, In : Science Translational Medicine. 12, 542, eaax4517.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold

Black, C., Kanczler, J. M., de Andrés, M. C., White, L. J., Savi, F. M., Bas, O., Saifzadeh, S., Henkel, J., Zannettino, A., Gronthos, S., Woodruff, M. A., Hutmacher, D. W. & Oreffo, R. O. C., Jul 2020, In : Biomaterials. 247, 119998.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Clinical protocol for a longitudinal cohort study employing systems biology to identify markers of vaccine immunogenicity in newborn infants in the gambia and papua New Guinea

Idoko, O. T., Smolen, K. K., Wariri, O., Imam, A., Shannon, C. P., Dibassey, T., Diray-Arce, J., Darboe, A., Strandmark, J., Ben-Othman, R., Odumade, O. A., McEnaney, K., Amenyogbe, N., Pomat, W. S., Van Haren, S., Sanchez-Schmitz, G., Brinkman, R. R., Steen, H., Hancock, R. E. W., Tebbutt, S. J. & 6 others, Richmond, P. C., Van Den Biggelaar, A. H. J., Kollmann, T. R., Levy, O., Ozonoff, A. & Kampmann, B., 1 Jan 2020, In : Frontiers in Pediatrics. 8, 197.

Research output: Contribution to journalArticle

Open Access

CMTM8 Is a Suppressor of Human Mesenchymal Stem Cell Osteogenic Differentiation and Promoter of Proliferation Via EGFR Signaling

H'Ng, C. H., Camp, E., Anderson, P. J., Zannettino, A. C. W. & Gronthos, S., Jul 2020, In : Stem cells and development. 29, 13, p. 823-834 12 p.

Research output: Contribution to journalArticle

Comprehensive geriatric assessment predicts azacitidine treatment duration and survival in older patients with myelodysplastic syndromes

Molga, A., Wall, M., Chhetri, R., Wee, L. Y., Singhal, D., Edwards, S., Singhal, N., Ross, D., To, L. B., Caughey, G., Shakib, S., Germing, U., To, T. & Hiwase, D., 1 Jan 2020, In : Journal of Geriatric Oncology. 11, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity

Etayash, H., Pletzer, D., Kumar, P., Straus, S. K. & Hancock, R. E. W., 10 Sep 2020, In : Journal of medicinal chemistry. 63, 17, p. 9228-9236 9 p.

Research output: Contribution to journalArticle

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease

Ohukainen, P., Kuusisto, S., Kettunen, J., Perola, M., Järvelin, M. R., Mäkinen, V. P. & Ala-Korpela, M., Feb 2020, In : Atherosclerosis. 294, p. 10-15 6 p.

Research output: Contribution to journalArticle

DNA extraction approaches substantially influence the assessment of the human breast milk microbiome

Douglas, C. A., Ivey, K. L., Papanicolas, L. E., Best, K. P., Muhlhausler, B. S. & Rogers, G. B., 10 Jan 2020, In : Scientific Reports. 10, 1, p. 123

Research output: Contribution to journalArticle

5 Citations (Scopus)

Early markers of cystic fibrosis structural lung disease: Follow-up of the ACFBAL cohort

Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB), 1 Apr 2020, In : European Respiratory Journal. 55, 4, 1901694.

Research output: Contribution to journalArticle

2 Citations (Scopus)

EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence

Porto, W. F., Irazazabal, L. N., Humblot, V., Haney, E. F., Ribeiro, S. M., Hancock, R. E. W., Ladram, A. & Franco, O. L., Sep 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 9, 129633.

Research output: Contribution to journalArticle

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vazquez, E. G., Davis, H., East, J. E., Arnold, R., Koppens, M. A. J., Blake, A., Domingo, E., Cunningham, C., Beggs, A. D., Pestinger, V., Loughrey, M. B., Wang, L. M., Lannagan, T. R. M., Woods, S. L., Worthley, D., Consortium, S., Tomlinson, I. & 3 others, Dunne, P. D., Maughan, T. & Leedham, S. J., 1 Jun 2020, In : Gut. 69, 6, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M-A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 24 Jan 2020, In : Nature communications. 11, 1, p. 499

Research output: Contribution to journalArticle

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M. A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 1 Dec 2020, In : Nature Communications. 11, 1, 499.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by HSP90 inhibition

Nassar, Z., Mah, C. Y., Centenera, M. M., Irani, S., Nguyen, E., Sadowski, M. C., Nagarajan, S. R., Moldovan, M., Lynn, D. J., Hoy, A. J., Butler, L. & Daly, R., 15 Jul 2020, In : Molecular Cancer Research.

Research output: Contribution to journalArticle

Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy

Dawson, R. E., Nieto Guil, A. F., Robertson, L., Piltz, S., Hughes, J. N. & Thomas, P., 1 Feb 2020, In : Neurobiology of Disease. 134, 104640.

Research output: Contribution to journalArticle

4 Citations (Scopus)

GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice

Friend, N., Noll, J. E., Opperman, K. S., Clark, K. C., Mrozik, K. M., Vandyke, K., Hewett, D. R. & Zannettino, A. C. W., 1 Jan 2020, In : PloS one. 15, 1, e0228408.

Research output: Contribution to journalArticle

GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia

Hata, M., Kinoshita, H., Hayakawa, Y., Konishi, M., Tsuboi, M., Oya, Y., Kurokawa, K., Hayata, Y., Nakagawa, H., Tateishi, K., Fujiwara, H., Hirata, Y., Worthley, D. L., Muranishi, Y., Furukawa, T., Kon, S., Tomita, H., Wang, T. C. & Koike, K., May 2020, In : Gastroenterology. 158, 6, p. 1650-1666.e15

Research output: Contribution to journalArticle

3 Citations (Scopus)

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

Algate, K., Haynes, D., Fitzsimmons, T., Romeo, O., Wagner, F., Holson, E., Reid, R., Fairlie, D., Bartold, P. & Cantley, M., 1 Jan 2020, In : Journal of Cellular Biochemistry. 121, 1, p. 244-258 15 p.

Research output: Contribution to journalArticle

HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways

Hng, C. H., Camp, E., Anderson, P., Breen, J., Zannettino, A. & Gronthos, S., 1 Dec 2020, In : Scientific reports. 10, 1, 11345.

Research output: Contribution to journalArticle

Open Access

Human DECR1 is an androgen-repressed survival factor that protects prostate tumour cells from ferroptosis

Nassar, Z., Mah, C. Y., Irani, S., Centenera, M. M., Helm, M., Moldovan, M., Horvath, L. G., Lynn, D. J., Selth, L. A., Hoy, A. J., Swinnen, J. V. & Butler, L., 20 Jul 2020, In : eLife.

Research output: Contribution to journalArticle

Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis

Nassar, Z. D., Mah, C. Y., Dehairs, J., Burvenich, I. J., Irani, S., Centenera, M. M., Helm, M., Shrestha, R. K., Moldovan, M., Don, A. S., Holst, J., Scott, A. M., Horvath, L. G., Lynn, D. J., Selth, L. A., Hoy, A. J., Swinnen, J. V. & Butler, L. M., Jul 2020, In : eLife. 9, p. 1-34 34 p., e54166.

Research output: Contribution to journalArticle

Open Access

Improving Australian National Bowel Cancer Screening Program outcomes through increased participation and cost-effective investment

Worthington, J., Lew, J. B., Feletto, E., Holden, C. A., Worthley, D. L., Miller, C. & Canfell, K., 1 Feb 2020, In : PloS one. 15, 2, e0227899.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1

Oishi, S., Zalucki, O., Vega, M. S., Harkins, D., Harvey, T. J., Kasherman, M., Davila, R. A., Hale, L., White, M., Piltz, S., Thomas, P., Burne, T. H. J., Harris, L. & Piper, M., 1 Apr 2020, In : Genes, Brain and Behavior. 19, 4, e12637.

Research output: Contribution to journalArticle

In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation

Wu, B. C., Skovbakke, S. L., Masoudi, H., Hancock, R. E. W. & Franzyk, H., 28 Aug 2020, In : Frontiers in Immunology. 11, 2102.

Research output: Contribution to journalArticle

Open Access

Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

WAERP, 1 Jan 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission

Pagani, I. S., Dang, P., Saunders, V. A., Grose, R., Shanmuganathan, N., Kok, C. H., Carne, L., Rwodzi, Z., Watts, S., McLean, J., Braley, J., Altamura, H., Yeung, D. T., Branford, S., Yong, A. S. M., White, D. L., Hughes, T. P. & Ross, D. M., Apr 2020, In : Leukemia. 34, 4, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mechanistic understanding enables the rational design of salicylanilide combination therapies for gram-negative infections

Copp, J. N., Pletzer, D., Brown, A. S., Van der Heijden, J., Miton, C. M., Edgar, R. J., Rich, M. H., Little, R. F., Williams, E. M., Hancock, R. E. W., Tokuriki, N. & Ackerley, D. F., 1 Sep 2020, In : mBio. 11, 5, p. 1-14 14 p., e02068-20.

Research output: Contribution to journalArticle

Open Access

Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy

Narasimhan, V., Wright, J. A., Churchill, M., Wang, T., Rosati, R., Lannagan, T. R. M., Vrbanac, L., Richardson, A. B., Kobayashi, H., Price, T., Tye, G. X. Y., Marker, J., Hewett, P. J., Flood, M. P., Pereira, S., Whitney, G. A., Michael, M., Tie, J., Mukherjee, S., Grandori, C. & 4 others, Heriot, A. G., Worthley, D. L., Ramsay, R. G. & Woods, S. L., 15 Jul 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 14, p. 3662-3670 9 p.

Research output: Contribution to journalArticle

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

Blimkie, T., Lee, A. H. Y. & Hancock, R., 1 Jun 2020, In : Current protocols in bioinformatics. 70, 1, p. e98

Research output: Contribution to journalArticle

Metal resistant bacteria on gold particles: Implications of how anthropogenic contaminants could affect natural gold biogeochemical cycling

Sanyal, S. K., Brugger, J., Etschmann, B., Pederson, S. M., Delport, P. W. J., Dixon, R., Tearle, R., Ludington, A., Reith, F. & Shuster, J., 20 Jul 2020, In : Science of the Total Environment. 727, 138698.

Research output: Contribution to journalArticle

Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells

Coleman, S. R., Blimkie, T., Falsafi, R. & Hancock, R. E. W., 1 Jan 2020, In : Antimicrobial Agents and Chemotherapy. 64, 3, e01999-19.

Research output: Contribution to journalArticle

2 Citations (Scopus)

National trends in antibiotic use in Australian residential aged care facilities

Sluggett, J., Moldovan, M., Lynn, D., Papanicolas, L., Crotty, M., Whitehead, C., Wesselingh, S., Rogers, G. & Inacio, M., 27 May 2020, In : Clinical Infectious Diseases.

Research output: Contribution to journalArticle

Outcomes and health care utilization of older patients with acute myeloid leukemia

Sharplin, K., Wee, L. Y. A., Singhal, D., Edwards, S., Danner, S., Lewis, I., Thomas, D., Wei, A., Yong, A. S. M. & Hiwase, D. K., 1 Jan 2020, (Accepted/In press) In : Journal of Geriatric Oncology.

Research output: Contribution to journalArticle

P0-Related Protein Accelerates Human Mesenchymal Stromal Cell Migration by Modulating VLA-5 Interactions with Fibronectin

Roubelakis, M. G., Tsaknakis, G., Lyu, F. J., Trohatou, O., Zannettino, A. C. W. & Watt, S. M., 29 Apr 2020, In : Cells. 9, 5

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pathways to a cancer-free future: A protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia

No Australians Dying of Bowel Cancer & Worthley, D., 21 Jun 2020, In : BMJ open. 10, 6

Research output: Contribution to journalArticle

Pharmacodynamics effects of CDK4/6 inhibitor LEE011 (ribociclib) in high-risk, localised prostate cancer: A study protocol for a randomised controlled phase II trial (LEEP study: LEE011 in high-risk, localised Prostate cancer)

Scheinberg, T., Kench, J., Stockler, M., Mahon, K. L., Sebastian, L., Stricker, P., Joshua, A. M., Woo, H., Thanigasalam, R., Ahmadi, N., Centenera, M. M., Butler, L. & Horvath, L. G., 26 Jan 2020, In : BMJ Open. 10, 1, e033667.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Plasma enabled devices for the selective capture and photodynamic identification of prostate cancer cells

Shirazi, H. S., Chan, K. M., Rouget, J., Ostrikov, K., McNicholas, K., Li, J., Butler, L., Gleadle, J. M., Vasilev, K. & Macgregor, M., 1 May 2020, In : Biointerphases. 15, 3, 031002.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Owen, K. L., Gearing, L. J., Zanker, D. J., Brockwell, N. K., Khoo, W. H., Roden, D. L., Cmero, M., Mangiola, S., Hong, M. K., Spurling, A. J., McDonald, M., Chan, C. L., Pasam, A., Lyons, R. J., Duivenvoorden, H. M., Ryan, A., Butler, L. M., Mariadason, J. M., Giang Phan, T., Hayes, V. M. & 7 others, Sandhu, S., Swarbrick, A., Corcoran, N. M., Hertzog, P. J., Croucher, P. I., Hovens, C. & Parker, B. S., 4 Jun 2020, In : EMBO Reports. 21, 6, e50162.

Research output: Contribution to journalArticle

4 Citations (Scopus)