Research Output

2020

AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

McDaniel, C. T., Panmanee, W., Winsor, G. L., Gill, E., Bertelli, C., Schurr, M. J., Dongare, P., Paul, A. T., Ko, S. H. B., Lau, G. W., Dasgupta, N., Bogue, A. L., Miller, W. E., Mortensen, J. E., Haslam, D. B., Dexheimer, P., Muruve, D. A., Aronow, B. J., Forbes, M. D. E., Danilczuk, M. & 4 others, Brinkman, F. S. L., Hancock, R. E. W., Meyer, T. J. & Hassett, D. J., 3 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4921-4930 10 p.

Research output: Contribution to journalArticle

Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia

Thomson, D. W., Shahrin, N. H., Wang, P. P. S., Wadham, C., Shanmuganathan, N., Scott, H. S., Dinger, M. E., Hughes, T. P., Schreiber, A. W. & Branford, S., 1 Aug 2020, In : Leukemia. 34, 8, p. 2051-2063 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract P507: Interplay Between Diet and Gut Microbiota, and Circulating Levels of Trimethylamine N-oxide: Findings From the Men’s Lifestyle Validation Study

Li, J., Li, Y., Ivey, K., Wang, D., Wilkinson, J., Franke, A., Chan, A., Huttenhower, C., Hu, F. B., Rimm, E. & Sun, Q., 3 Mar 2020, In : Circulation. 141, Suppl_1

Research output: Contribution to journalArticle

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

Kamili, A., Gifford, A. J., Li, N., Mayoh, C., Chow, S. O., Failes, T. W., Eden, G. L., Cadiz, R., Xie, J., Lukeis, R. E., Norris, M. D., Haber, M., McCowage, G. B., Arndt, G. M., Trahair, T. N. & Fletcher, J. I., 3 Mar 2020, In : British Journal of Cancer. 122, 5, p. 680-691 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A costing study of bortezomib shows equivalence of its real-world costs to conventional treatment

Thompson, J. F., Teh, Z., Chen, Y., Gardiner, J., Bednarz, J. M., Thompson, G. N., Lee, C., Horvath, N., Bardy, P. & Yeung, D., 1 May 2020, In : British Journal of Haematology. 189, 3, p. e76-e79

Research output: Contribution to journalLetter

Allogeneic primary mesenchymal stem/stromal cell aggregates within poly(N-isopropylacrylamide-co-acrylic acid) hydrogel for osteochondral regeneration

Zhang, J., Zhang, M., Lin, R., Yun, S., Du, Y., Wang, L., Yao, Q., Zannettino, A. & Zhang, H., Mar 2020, In : Applied Materials Today. 18, 100487.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, W., Qiu, J., Nassar, Z. D., Shaw, P. N., McMahon, K. A., Ferguson, C., Parton, R. G., Riggins, G. J., Harris, J. M. & Parat, M. O., 1 Mar 2020, In : Journal of Cellular and Molecular Medicine. 24, 6, p. 3724-3738 15 p.

Research output: Contribution to journalArticle

Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer

Miladinovic, D., Cusick, T., Mahon, K. L., Haynes, A. M., Cortie, C. H., Meyer, B. J., Stricker, P. D., Wittert, G. A., Butler, L. M., Horvath, L. G. & Hoy, A. J., Jun 2020, In : Cancers. 12, 6, 1385.

Research output: Contribution to journalArticle

Open Access

Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men

Nguyen, L. H., Ma, W., Wang, D. D., Cao, Y., Mallick, H., Gerbaba, T. K., Lloyd-Price, J., Abu-Ali, G., Hall, A. B., Sikavi, D., Drew, D. A., Mehta, R. S., Arze, C., Joshi, A. D., Yan, Y., Branck, T., DuLong, C., Ivey, K. L., Ogino, S., Rimm, E. B. & 5 others, Song, M., Garrett, W. S., Izard, J., Huttenhower, C. & Chan, A. T., 20 Jan 2020, In : Gastroenterology.

Research output: Contribution to journalArticle

Bacterial Aggregation Triggered by Fibril Forming Tryptophan-Rich Sequences: Effects of Peptide Side Chain and Membrane Phospholipids

Bagheri, M., Nikolenko, H., Arasteh, S., Rezaei, N., Behzadi, M., Dathe, M. & Hancock, R. E. W., 17 Jun 2020, In : ACS applied materials & interfaces. 12, 24, p. 26852-26867 16 p.

Research output: Contribution to journalArticle

Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold

Black, C., Kanczler, J. M., de Andrés, M. C., White, L. J., Savi, F. M., Bas, O., Saifzadeh, S., Henkel, J., Zannettino, A., Gronthos, S., Woodruff, M. A., Hutmacher, D. W. & Oreffo, R. O. C., Jul 2020, In : Biomaterials. 247, 119998.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L. & 6 others, Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F. & Claesson, M. J., 1 Dec 2020, In : Nature Communications. 11, 1, 1512.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Comprehensive geriatric assessment predicts azacitidine treatment duration and survival in older patients with myelodysplastic syndromes

Molga, A., Wall, M., Chhetri, R., Wee, L. Y., Singhal, D., Edwards, S., Singhal, N., Ross, D., To, L. B., Caughey, G., Shakib, S., Germing, U., To, T. & Hiwase, D., 1 Jan 2020, In : Journal of Geriatric Oncology. 11, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis

Brown, A. L., Hahn, C., Hiwase, D., Godley, L. A. & Scott, H. S., 2 Jan 2020, In : Leukemia and Lymphoma. 61, 1, p. 246-247 2 p.

Research output: Contribution to journalLetter

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease

Ohukainen, P., Kuusisto, S., Kettunen, J., Perola, M., Järvelin, M. R., Mäkinen, V. P. & Ala-Korpela, M., Feb 2020, In : Atherosclerosis. 294, p. 10-15 6 p.

Research output: Contribution to journalArticle

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue

Gao, Y., Wilson, G. R., Stephenson, S. E. M., Oulad-Abdelghani, M., Charlet-Berguerand, N., Bozaoglu, K., McLean, C. A., Thomas, P., Finkelstein, D. I. & Lockhart, P. J., 30 Mar 2020, In : Molecular brain. 13, 1, 52.

Research output: Contribution to journalArticle

3 Citations (Scopus)

DNA extraction approaches substantially influence the assessment of the human breast milk microbiome

Douglas, C. A., Ivey, K. L., Papanicolas, L. E., Best, K. P., Muhlhausler, B. S. & Rogers, G. B., 10 Jan 2020, In : Scientific Reports. 10, 1, p. 123

Research output: Contribution to journalArticle

4 Citations (Scopus)

Early markers of cystic fibrosis structural lung disease: Follow-up of the ACFBAL cohort

Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB), 1 Apr 2020, In : European Respiratory Journal. 55, 4, 1901694.

Research output: Contribution to journalArticle

2 Citations (Scopus)

EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence

Porto, W. F., Irazazabal, L. N., Humblot, V., Haney, E. F., Ribeiro, S. M., Hancock, R. E. W., Ladram, A. & Franco, O. L., Sep 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 9, 129633.

Research output: Contribution to journalArticle

Effects of aging on the motor, cognitive and affective behaviors, neuroimmune responses and hippocampal gene expression

Singhal, G., Morgan, J., Jawahar, M. C., Corrigan, F., Jaehne, E. J., Toben, C., Breen, J., Pederson, S. M., Manavis, J., Hannan, A. J. & Baune, B. T., 6 Apr 2020, In : Behavioural Brain Research. 383, 112501.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Elevated levels of tumour apolipoprotein D independently predict poor outcome in breast cancer patients

Jankovic-Karasoulos, T., Bianco-Miotto, T., Butler, M. S., Butler, L. M., McNeil, C. M., O’Toole, S. A., Millar, E. K. A., Sakko, A. J., Ruiz, A. I., Birrell, S. N., Sutherland, R. L., Hickey, T. E., Tilley, W. D. & Ricciardelli, C., 1 Jun 2020, In : Histopathology. 76, 7, p. 976-987 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2

Dutta, R., Zhang, T. Y., Köhnke, T., Thomas, D., Linde, M., Gars, E., Stafford, M., Kaur, S., Nakauchi, Y., Yin, R., Azizi, A., Narla, A. & Majeti, R., 1 Apr 2020, In : Journal of Clinical Investigation. 130, 4, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia

Hochhaus, A., Baccarani, M., Silver, R. T., Schiffer, C., Apperley, J. F., Cervantes, F., Clark, R. E., Cortes, J. E., Deininger, M. W., Guilhot, F., Hjorth-Hansen, H., Hughes, T. P., Janssen, J. J. W. M., Kantarjian, H. M., Kim, D. W., Larson, R. A., Lipton, J. H., Mahon, F. X., Mayer, J., Nicolini, F. & 14 others, Niederwieser, D., Pane, F., Radich, J. P., Rea, D., Richter, J., Rosti, G., Rousselot, P., Saglio, G., Saußele, S., Soverini, S., Steegmann, J. L., Turkina, A., Zaritskey, A. & Hehlmann, R., Apr 2020, In : Leukemia. 34, 4, p. 966-984 19 p.

Research output: Contribution to journalReview article

29 Citations (Scopus)

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vazquez, E. G., Davis, H., East, J. E., Arnold, R., Koppens, M. A. J., Blake, A., Domingo, E., Cunningham, C., Beggs, A. D., Pestinger, V., Loughrey, M. B., Wang, L. M., Lannagan, T. R. M., Woods, S. L., Worthley, D., Consortium, S., Tomlinson, I. & 3 others, Dunne, P. D., Maughan, T. & Leedham, S. J., 1 Jun 2020, In : Gut. 69, 6, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M-A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 24 Jan 2020, In : Nature communications. 11, 1, p. 499

Research output: Contribution to journalArticle

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M. A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 1 Dec 2020, In : Nature Communications. 11, 1, 499.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by HSP90 inhibition

Nassar, Z., Mah, C. Y., Centenera, M. M., Irani, S., Nguyen, E., Sadowski, M. C., Nagarajan, S. R., Moldovan, M., Lynn, D. J., Hoy, A. J., Butler, L. & Daly, R., 15 Jul 2020, In : Molecular Cancer Research.

Research output: Contribution to journalArticle

Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy

Dawson, R. E., Nieto Guil, A. F., Robertson, L., Piltz, S., Hughes, J. N. & Thomas, P., 1 Feb 2020, In : Neurobiology of Disease. 134, 104640.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genetic Biocontrol for Invasive Species

Teem, J. L., Alphey, L., Descamps, S., Edgington, M. P., Edwards, O., Gemmell, N., Harvey-Samuel, T., Melnick, R. L., Oh, K. P., Piaggio, A. J., Saah, J. R., Schill, D., Thomas, P., Smith, T. & Roberts, A., 25 May 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 452.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Genomics of therapy-related myeloid neoplasms

Kuzmanovic, T., Patel, B. J., Sanikommu, S. R., Nagata, Y., Awada, H., Kerr, C. M., Przychodzen, B. P., Jha, B. K., Hiwase, D., Singhal, D., Advani, A. S., Nazha, A., Gerds, A. T., Carraway, H. E., Sekeres, M. A., Mukherjee, S., Maciejewski, J. P. & Radivoyevitch, T., 1 Mar 2020, In : Haematologica. 105, 3, p. E98-E101

Research output: Contribution to journalLetter

3 Citations (Scopus)

GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice

Friend, N., Noll, J. E., Opperman, K. S., Clark, K. C., Mrozik, K. M., Vandyke, K., Hewett, D. R. & Zannettino, A. C. W., 1 Jan 2020, In : PloS one. 15, 1, e0228408.

Research output: Contribution to journalArticle

High-risk B-cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse

McClure, B. J., Heatley, S. L., Rehn, J., Breen, J., Sutton, R., Hughes, T. P., Suppiah, R., Revesz, T., Osborn, M., White, D., Yeung, D. T. & White, D. L., 1 Jan 2020, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalLetter

Open Access

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

Algate, K., Haynes, D., Fitzsimmons, T., Romeo, O., Wagner, F., Holson, E., Reid, R., Fairlie, D., Bartold, P. & Cantley, M., 1 Jan 2020, In : Journal of Cellular Biochemistry. 121, 1, p. 244-258 15 p.

Research output: Contribution to journalArticle

HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways

Hng, C. H., Camp, E., Anderson, P., Breen, J., Zannettino, A. & Gronthos, S., 1 Dec 2020, In : Scientific reports. 10, 1, 11345.

Research output: Contribution to journalArticle

Open Access

Human DECR1 is an androgen-repressed survival factor that protects prostate tumour cells from ferroptosis

Nassar, Z., Mah, C. Y., Irani, S., Centenera, M. M., Helm, M., Moldovan, M., Horvath, L. G., Lynn, D. J., Selth, L. A., Hoy, A. J., Swinnen, J. V. & Butler, L., 20 Jul 2020, In : eLife.

Research output: Contribution to journalArticle

Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis

Nassar, Z. D., Mah, C. Y., Dehairs, J., Burvenich, I. J., Irani, S., Centenera, M. M., Helm, M., Shrestha, R. K., Moldovan, M., Don, A. S., Holst, J., Scott, A. M., Horvath, L. G., Lynn, D. J., Selth, L. A., Hoy, A. J., Swinnen, J. V. & Butler, L. M., Jul 2020, In : eLife. 9, p. 1-34 34 p., e54166.

Research output: Contribution to journalArticle

Open Access

Insights into the mechanism of action of two analogues of aurein 2.2

Raheem, N., Kumar, P., Lee, E., Cheng, J. T. J., Hancock, R. E. W. & Straus, S. K., 1 Jun 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 183262.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse

de Vries, M., Carpinelli, M., Rutland, E., Hatzipantelis, A., Partridge, D., Auden, A., Anderson, P., De Groef, B., Wu, H., Osterwalder, M., Visel, A., Jane, S. M. & Dworkin, S., 15 Mar 2020, In : Developmental Biology. 459, 2, p. 194-203 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vitro and in vivo antibiotic capacity of two host defense peptides

Arenas, I., Ibarra, M. A., Santana, F. L., Villegas, E., Hancock, R. E. W. & Corzo, G., Jul 2020, In : Antimicrobial Agents and Chemotherapy. 64, 7, e00145-20.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

WAERP, 1 Jan 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission

Pagani, I. S., Dang, P., Saunders, V. A., Grose, R., Shanmuganathan, N., Kok, C. H., Carne, L., Rwodzi, Z., Watts, S., McLean, J., Braley, J., Altamura, H., Yeung, D. T., Branford, S., Yong, A. S. M., White, D. L., Hughes, T. P. & Ross, D. M., Apr 2020, In : Leukemia. 34, 4, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lipogenic effects of androgen signaling in normal and malignant prostate

Mah, C. Y., Nassar, Z. D., Swinnen, J. V. & Butler, L. M., Jul 2020, In : Asian Journal of Urology. 7, 3, p. 258-270 13 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

Blimkie, T., Lee, A. H. Y. & Hancock, R., 1 Jun 2020, In : Current protocols in bioinformatics. 70, 1, p. e98

Research output: Contribution to journalArticle

Metal resistant bacteria on gold particles: Implications of how anthropogenic contaminants could affect natural gold biogeochemical cycling

Sanyal, S. K., Brugger, J., Etschmann, B., Pederson, S. M., Delport, P. W. J., Dixon, R., Tearle, R., Ludington, A., Reith, F. & Shuster, J., 20 Jul 2020, In : Science of the Total Environment. 727, 138698.

Research output: Contribution to journalArticle

Multispectral characterisation of mesenchymal stem/stromal cells: Age, cell cycle, senescence, and pluripotency

Campbell, J. M., Habibalahi, A., Mahbub, S., Paton, S., Gronthos, S. & Goldys, E., 1 Jan 2020, Label-Free Biomedical Imaging and Sensing (LBIS) 2020. Shaked, N. T. & Hayden, O. (eds.). SPIE, 112510F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11251).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)