Research Output

2020

AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

McDaniel, C. T., Panmanee, W., Winsor, G. L., Gill, E., Bertelli, C., Schurr, M. J., Dongare, P., Paul, A. T., Ko, S. H. B., Lau, G. W., Dasgupta, N., Bogue, A. L., Miller, W. E., Mortensen, J. E., Haslam, D. B., Dexheimer, P., Muruve, D. A., Aronow, B. J., Forbes, M. D. E., Danilczuk, M. & 4 others, Brinkman, F. S. L., Hancock, R., Meyer, T. J. & Hassett, D. J., 3 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4921-4930 10 p.

Research output: Contribution to journalArticle

Abstract P507: Interplay Between Diet and Gut Microbiota, and Circulating Levels of Trimethylamine N-oxide: Findings From the Men’s Lifestyle Validation Study

Li, J., Li, Y., Ivey, K., Wang, D., Wilkinson, J., Franke, A., Chan, A., Huttenhower, C., Hu, F. B., Rimm, E. & Sun, Q., 3 Mar 2020, In : Circulation. 141, Suppl_1

Research output: Contribution to journalArticle

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

Kamili, A., Gifford, A. J., Li, N., Mayoh, C., Chow, S. O., Failes, T. W., Eden, G. L., Cadiz, R., Xie, J., Lukeis, R. E., Norris, M. D., Haber, M., McCowage, G. B., Arndt, G. M., Trahair, T. N. & Fletcher, J. I., 3 Mar 2020, In : British Journal of Cancer. 122, 5, p. 680-691 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A costing study of bortezomib shows equivalence of its real-world costs to conventional treatment

Thompson, J. F., Teh, Z., Chen, Y., Gardiner, J., Bednarz, J. M., Thompson, G. N., Lee, C., Horvath, N., Bardy, P. & Yeung, D., 1 Jan 2020, In : British Journal of Haematology.

Research output: Contribution to journalLetter

A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, W., Qiu, J., Nassar, Z., Shaw, P. N., McMahon, K. A., Ferguson, C., Parton, R. G., Riggins, G. J., Harris, J. M. & Parat, M. O., 1 Mar 2020, In : Journal of Cellular and Molecular Medicine. 24, 6, p. 3724-3738 15 p.

Research output: Contribution to journalArticle

Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men

Nguyen, L. H., Ma, W., Wang, D. D., Cao, Y., Mallick, H., Gerbaba, T. K., Lloyd-Price, J., Abu-Ali, G., Hall, A. B., Sikavi, D., Drew, D. A., Mehta, R. S., Arze, C., Joshi, A. D., Yan, Y., Branck, T., DuLong, C., Ivey, K. L., Ogino, S., Rimm, E. B. & 5 others, Song, M., Garrett, W. S., Izard, J., Huttenhower, C. & Chan, A. T., 20 Jan 2020, In : Gastroenterology.

Research output: Contribution to journalArticle

Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold

Black, C., Kanczler, J. M., de Andrés, M. C., White, L. J., Savi, F. M., Bas, O., Saifzadeh, S., Henkel, J., Zannettino, A., Gronthos, S., Woodruff, M. A., Hutmacher, D. W. & Oreffo, R. O. C., 1 Jul 2020, In : Biomaterials. 247, 119998.

Research output: Contribution to journalArticle

Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

Ryan, F. J., Ahern, A. M., Fitzgerald, R. S., Laserna-Mendieta, E. J., Power, E. M., Clooney, A. G., O’Donoghue, K. W., McMurdie, P. J., Iwai, S., Crits-Christoph, A., Sheehan, D., Moran, C., Flemer, B., Zomer, A. L., Fanning, A., O’Callaghan, J., Walton, J., Temko, A., Stack, W., Jackson, L. & 6 others, Joyce, S. A., Melgar, S., DeSantis, T. Z., Bell, J. T., Shanahan, F. & Claesson, M. J., 1 Dec 2020, In : Nature Communications. 11, 1, 1512.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Comprehensive geriatric assessment predicts azacitidine treatment duration and survival in older patients with myelodysplastic syndromes

Molga, A., Wall, M., Chhetri, R., Wee, L. Y., Singhal, D., Edwards, S., Singhal, N., Ross, D., To, L. B., Caughey, G., Shakib, S., Germing, U., To, T. & Hiwase, D., 1 Jan 2020, In : Journal of Geriatric Oncology. 11, 1, p. 114-120 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis

Brown, A. L., Hahn, C., Hiwase, D., Godley, L. A. & Scott, H. S., 2 Jan 2020, In : Leukemia and Lymphoma. 61, 1, p. 246-247 2 p.

Research output: Contribution to journalLetter

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease

Ohukainen, P., Kuusisto, S., Kettunen, J., Perola, M., Järvelin, M. R., Makinen, V-P. & Ala-Korpela, M., 1 Feb 2020, In : Atherosclerosis. 294, p. 10-15 6 p.

Research output: Contribution to journalArticle

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue

Gao, Y., Wilson, G. R., Stephenson, S. E. M., Oulad-Abdelghani, M., Charlet-Berguerand, N., Bozaoglu, K., McLean, C. A., Thomas, P., Finkelstein, D. I. & Lockhart, P. J., 30 Mar 2020, In : Molecular brain. 13, 1, 52.

Research output: Contribution to journalArticle

DNA extraction approaches substantially influence the assessment of the human breast milk microbiome

Douglas, C. A., Ivey, K. L., Papanicolas, L. E., Best, K. P., Muhlhausler, B. S. & Rogers, G. B., 10 Jan 2020, In : Scientific Reports. 10, 1, p. 123

Research output: Contribution to journalArticle

1 Citation (Scopus)

Early markers of cystic fibrosis structural lung disease: Follow-up of the ACFBAL cohort

Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB), 1 Apr 2020, In : European Respiratory Journal. 55, 4, 1901694.

Research output: Contribution to journalArticle

1 Citation (Scopus)

EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence

Porto, W. F., Irazazabal, L. N., Humblot, V., Haney, E. F., Ribeiro, S. M., Hancock, R. E. W., Ladram, A. & Franco, O. L., Sep 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 9, 129633.

Research output: Contribution to journalArticle

Effects of aging on the motor, cognitive and affective behaviors, neuroimmune responses and hippocampal gene expression

Singhal, G., Morgan, J., Jawahar, M. C., Corrigan, F., Jaehne, E. J., Toben, C., Breen, J., Pederson, S. M., Manavis, J., Hannan, A. J. & Baune, B. T., 6 Apr 2020, In : Behavioural Brain Research. 383, 112501.

Research output: Contribution to journalArticle

Elevated levels of tumour apolipoprotein D independently predict poor outcome in breast cancer patients

Jankovic-Karasoulos, T., Bianco-Miotto, T., Butler, M. S., Butler, L. M., McNeil, C. M., O’Toole, S. A., Millar, E. K. A., Sakko, A. J., Ruiz, A. I., Birrell, S. N., Sutherland, R. L., Hickey, T. E., Tilley, W. D. & Ricciardelli, C., 1 Jun 2020, In : Histopathology. 76, 7, p. 976-987 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2

Dutta, R., Zhang, T. Y., Köhnke, T., Thomas, D., Linde, M., Gars, E., Stafford, M., Kaur, S., Nakauchi, Y., Yin, R., Azizi, A., Narla, A. & Majeti, R., 1 Apr 2020, In : Journal of Clinical Investigation. 130, 4, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

Kleeman, S. O., Koelzer, V. H., Jones, H. J. S., Vazquez, E. G., Davis, H., East, J. E., Arnold, R., Koppens, M. A. J., Blake, A., Domingo, E., Cunningham, C., Beggs, A. D., Pestinger, V., Loughrey, M. B., Wang, L. M., Lannagan, T. R. M., Woods, S. L., Worthley, D., Consortium, S., Tomlinson, I. & 3 others, Dunne, P. D., Maughan, T. & Leedham, S. J., 1 Jun 2020, In : Gut. 69, 6, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M-A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 24 Jan 2020, In : Nature communications. 11, 1, p. 499

Research output: Contribution to journalArticle

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Kennedy, S. A., Jarboui, M. A., Srihari, S., Raso, C., Bryan, K., Dernayka, L., Charitou, T., Bernal-Llinares, M., Herrera-Montavez, C., Krstic, A., Matallanas, D., Kotlyar, M., Jurisica, I., Curak, J., Wong, V., Stagljar, I., LeBihan, T., Imrie, L., Pillai, P., Lynn, M. A. & 21 others, Fasterius, E., Al-Khalili Szigyarto, C., Breen, J., Kiel, C., Serrano, L., Rauch, N., Rukhlenko, O., Kholodenko, B. N., Iglesias-Martinez, L. F., Ryan, C. J., Pilkington, R., Cammareri, P., Sansom, O., Shave, S., Auer, M., Horn, N., Klose, F., Ueffing, M., Boldt, K., Lynn, D. J. & Kolch, W., 1 Dec 2020, In : Nature Communications. 11, 1, 499.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy

Dawson, R. E., Nieto Guil, A. F., Robertson, L., Piltz, S., Hughes, J. N. & Thomas, P., 1 Feb 2020, In : Neurobiology of Disease. 134, 104640.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Genetic Biocontrol for Invasive Species

Teem, J. L., Alphey, L., Descamps, S., Edgington, M. P., Edwards, O., Gemmell, N., Harvey-Samuel, T., Melnick, R. L., Oh, K. P., Piaggio, A. J., Saah, J. R., Schill, D., Thomas, P., Smith, T. & Roberts, A., 25 May 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 452.

Research output: Contribution to journalReview article

Open Access

GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice

Friend, N., Noll, J., Opperman, K. S., Clark, K. C., Mrozik, K., Vandyke, K., Hewett, D. & Zannettino, A., 1 Jan 2020, In : PLoS ONE. 15, 1, e0228408.

Research output: Contribution to journalArticle

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

Algate, K., Haynes, D., Fitzsimmons, T., Romeo, O., Wagner, F., Holson, E., Reid, R., Fairlie, D., Bartold, P. & Cantley, M., 1 Jan 2020, In : Journal of Cellular Biochemistry. 121, 1, p. 244-258 15 p.

Research output: Contribution to journalArticle

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse

de Vries, M., Carpinelli, M., Rutland, E., Hatzipantelis, A., Partridge, D., Auden, A., Anderson, P., De Groef, B., Wu, H., Osterwalder, M., Visel, A., Jane, S. M. & Dworkin, S., 15 Mar 2020, In : Developmental Biology. 459, 2, p. 194-203 10 p.

Research output: Contribution to journalArticle

Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission

Pagani, I., Dang, Y., Saunders, V., Grose, R., Shanmuganathan, N., Kok, C., Carne, L., Rwodzi, Z., Watts, S., McLean, J., Braley, J., Altamura, H., Yeung, D., Branford, S., Yong, A., White, D., Hughes, T. & Ross, D., 1 Apr 2020, In : Leukemia. 34, 4, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Lipogenic effects of androgen signaling in normal and malignant prostate

Mah, C. Y., Nassar, Z., Swinnen, J. V. & Butler, L., 1 Jan 2020, In : Asian Journal of Urology.

Research output: Contribution to journalReview article

1 Citation (Scopus)

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

Blimkie, T., Lee, A. H. Y. & Hancock, R., 1 Jun 2020, In : Current protocols in bioinformatics. 70, 1, p. e98

Research output: Contribution to journalArticle

Metal resistant bacteria on gold particles: Implications of how anthropogenic contaminants could affect natural gold biogeochemical cycling

Sanyal, S. K., Brugger, J., Etschmann, B., Pederson, S. M., Delport, P. W. J., Dixon, R., Tearle, R., Ludington, A., Reith, F. & Shuster, J., 20 Jul 2020, In : Science of the Total Environment. 727, 138698.

Research output: Contribution to journalArticle

Multispectral characterisation of mesenchymal stem/stromal cells: Age, cell cycle, senescence, and pluripotency

Campbell, J. M., Habibalahi, A., Mahbub, S., Paton, S., Gronthos, S. & Goldys, E., 1 Jan 2020, Label-Free Biomedical Imaging and Sensing (LBIS) 2020. Shaked, N. T. & Hayden, O. (eds.). SPIE, Vol. 11251. 112510F

Research output: Chapter in Book/Report/Conference proceedingConference contribution

NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection

Alford, M. A., Baghela, A., Yeung, A. T. Y., Pletzer, D. & Hancock, R. E. W., 5 May 2020, In : Frontiers in Microbiology. 11, 773.

Research output: Contribution to journalArticle

Open Access

P0-Related Protein Accelerates Human Mesenchymal Stromal Cell Migration by Modulating VLA-5 Interactions with Fibronectin

Roubelakis, M. G., Tsaknakis, G., Lyu, F. J., Trohatou, O., Zannettino, A. C. W. & Watt, S. M., 29 Apr 2020, In : Cells. 9, 5

Research output: Contribution to journalArticle

Pharmacodynamics effects of CDK4/6 inhibitor LEE011 (ribociclib) in high-risk, localised prostate cancer: A study protocol for a randomised controlled phase II trial (LEEP study: LEE011 in high-risk, localised Prostate cancer)

Scheinberg, T., Kench, J., Stockler, M., Mahon, K. L., Sebastian, L., Stricker, P., Joshua, A. M., Woo, H., Thanigasalam, R., Ahmadi, N., Centenera, M. M., Butler, L. & Horvath, L. G., 26 Jan 2020, In : BMJ Open. 10, 1, e033667.

Research output: Contribution to journalArticle

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Owen, K. L., Gearing, L. J., Zanker, D. J., Brockwell, N. K., Khoo, W. H., Roden, D. L., Cmero, M., Mangiola, S., Hong, M. K., Spurling, A. J., McDonald, M., Chan, C. L., Pasam, A., Lyons, R. J., Duivenvoorden, H. M., Ryan, A., Butler, L. M., Mariadason, J. M., Giang Phan, T., Hayes, V. M. & 7 others, Sandhu, S., Swarbrick, A., Corcoran, N. M., Hertzog, P. J., Croucher, P. I., Hovens, C. & Parker, B. S., 4 Jun 2020, In : EMBO Reports. 21, 6, e50162.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Protect commensal gut bacteria to improve antimicrobial stewardship

Papanicolas, L. E., Warner, M., Wesselingh, S. L. & Rogers, G. B., 1 Jan 2020, In : Clinical Microbiology and Infection.

Research output: Contribution to journalComment/debate

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K., Trim, P., Snel, M., Kamei, M., Martin, S., Fitter, S., Tian, S., Wang, X. & 3 others, Butler, L., Zannettino, A. & Proud, C., 1 Jan 2020, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

Respiratory Viruses Cause Late Morbidity in Recipients of Hematopoietic Stem Cell Transplantation

Marinelli, T., Wee, L. Y., Rowe, E., Chhetri, R., Friel, O., Higgins, G., Bardy, P., Singhal, D., Pradhan, A., Crawford, L. & Hiwase, D. K., 1 Apr 2020, In : Biology of Blood and Marrow Transplantation. 26, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML

Brown, A. L., Arts, P., Carmichael, C. L., Babic, M., Dobbins, J., Chong, C. E., Schreiber, A. W., Feng, J., Phillips, K., Wang, P. P. S., Ha, T., Homan, C. C., King-Smith, S. L., Rawlings, L., Vakulin, C., Dubowsky, A., Burdett, J., Moore, S., McKavanagh, G., Henry, D. & 39 others, Wells, A., Mercorella, B., Nicola, M., Suttle, J., Wilkins, E., Li, X. C., Michaud, J., Brautigan, P., Cannon, P., Altree, M., Jaensch, L., Fine, M., Butcher, C., D'Andrea, R. J., Lewis, I. D., Hiwase, D., Papaemmanuil, E., Horwitz, M. S., Natsoulis, G., Rienhoff, H. Y., Patton, N., Mapp, S., Susman, R., Morgan, S., Cooney, J., Currie, M., Popat, U., Bochtler, T., Izraeli, S., Bradstock, K., Godley, L. A., Kr¨amer, A., Fröhling, S., Wei, A. H., Forsyth, C., Fan, H. M., Poplawski, N. K., Hahn, C. N. & Scott, H. S., 24 Mar 2020, In : Blood Advances. 4, 6, p. 1131-1144 14 p.

Research output: Contribution to journalArticle

Screening for deficits using the G8 and VES-13 in older patients with Myelodysplastic syndromes

Molga, A., Wall, M., Wee, L. Y., Chhetri, R., Singhal, D., Singhal, N., To, L. B., Shakib, S., To, T. & Hiwase, D., 1 Jan 2020, In : Journal of Geriatric Oncology. 11, 1, p. 128-130 3 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Arias, M., Haney, E. F., Hilchie, A. L., Corcoran, J. A., Hyndman, M. E., Hancock, R. E. W. & Vogel, H. J., 1 Jan 2020, In : Biochimica et Biophysica Acta - Biomembranes. 183228.

Research output: Contribution to journalArticle

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition

Khan, A., Valli, E., Lam, H., Scott, D. A., Murray, J., Hanssen, K. M., Eden, G., Gamble, L. D., Pandher, R., Flemming, C. L., Allan, S., Osterman, A. L., Haber, M., Norris, M. D., Fletcher, J. I. & Yu, D. M. T., 23 Apr 2020, In : Oncogene. 39, 17, p. 3555-3570 16 p.

Research output: Contribution to journalArticle

The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging

Cakouros, D. & Gronthos, S., Aug 2020, In : Bone. 137, 115440.

Research output: Contribution to journalArticle

The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL

Tavakoli Shirazi, P., Eadie, L., Heatley, S., Hughes, T., Yeung, D. & White, D., 18 Feb 2020, In : British Journal of Cancer. 122, 4, p. 455-464 10 p.

Research output: Contribution to journalReview article

The importance of reporting house dust mite endotoxin abundance: Impact on the lung transcriptome

Canadian Respiratory Research Network, Jun 2020, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 6, p. L1229-L1236

Research output: Contribution to journalArticle

Open Access

The non-specific and sex-differential effects of vaccines

Aaby, P., Benn, C. S., Flanagan, K. L., Klein, S. L., Kollmann, T. R., Lynn, D. J. & Shann, F., 1 Jan 2020, (Accepted/In press) In : Nature Reviews Immunology.

Research output: Contribution to journalReview article

Open Access