Molecular Imaging And Therapy Research Unit

Research Output

2020

Advanced resistance studies identify two discrete mechanisms in Staphylococcus aureus to overcome antibacterial compounds that target biotin protein ligase

Hayes, A. J., Satiaputra, J., Sternicki, L. M., Paparella, A. S., Feng, Z., Lee, K. J., Blanco-Rodriguez, B., Tieu, W., Eijkelkamp, B. A., Shearwin, K. E., Pukala, T. L., Abell, A. D., Booker, G. W. & Polyak, S. W., Apr 2020, In : Antibiotics. 9, 4, 165.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: Divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D

Kuan, K. K. W., Markwell-Heys, A. W., Cruickshank, M. C., Tran, D. P., Adlington, R. M., Baldwin, J. E. & George, J. H., 15 Jun 2019, In : Bioorganic and Medicinal Chemistry. 27, 12, p. 2449-2465 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Immuno-PET of innate immune markers CD11b and IL-1b detects inflammation in murine colitis

Dmochowska, N., Tieu, W., Keller, M. D., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P., 1 Jun 2019, In : Journal of Nuclear Medicine. 60, 6, p. 858-863 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Rapid and automated production of [68Ga]gallium chloride and [68Ga]Ga-DOTA-TATE on a medical cyclotron

Tieu, W., Hollis, C. A., Kuan, K., Takhar, P., Stuckings, M., Spooner, N. & Malinconico, M., 1 Jul 2019, In : Nuclear Medicine and Biology. 74-75, p. 12-18 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

Lee, K. J., Tieu, W., Blanco-Rodriguez, B., Paparella, A. S., Yu, J., Hayes, A., Feng, J., Marshall, A. C., Noll, B., Milne, R., Cini, D., Wilce, M. C. J., Booker, G. W., Bruning, J. B., Polyak, S. W. & Abell, A. D., 21 Aug 2019, In : ACS Chemical Biology.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

18-Fluoride labeled sodium fluoride positron emission tomography with computer tomography: the impact of pretreatment staging in intermediate- and high-risk prostate cancer

Harley, S. JD., Hoffmann, R., Bartholomeusz, D., Sutherland, P., Chatterton, B., Kitchener, M., Takhar, P., Tsopelas, C., Fuller, A., Wells, R., Singh-Rai, R. & Bolt, J., Jun 2018, In : Prostate International. 6, 2, p. 50-54 5 p.

Research output: Contribution to journalArticle

Crystal structure of highly glycosylated human leukocyte elastase in complex with an S200 site binding inhibitor

Hochscherf, J., Pietsch, M., Tieu, W., Kuan, K., Abell, A. D., Gütschow, M. & Niefind, K., Aug 2018, In : Acta Crystallographica Section F: Structural Biology Communications. 74, 8, p. 480-489 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Immuno-PET of innate immune markers CD11b and 1IL-1β detect inflammation in murine colitis.

Dmochowska, N., Tieu, W., Keller, M., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P., 2018, In : Journal of Nuclear Medicine. JNUMED/2018/219287.

Research output: Contribution to journalArticle

In vivo PET of innate immune responses in murine DSS colitis

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H. R., Keller, M., Tieu, W. & Hughes, P., 2018.

Research output: Contribution to conferencePoster

2017

18F-FDG-PET: A non-invasive tool for imaging colitis

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H. R., Keller, M., Tieu, W. & Hughes, P., 2017.

Research output: Contribution to conferencePoster

18F-FDG-PET: A non-invasive tool for imaging colitis: Australasian Society for Immunology Annual Scientific Meeting

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H., Keller, M., Tieu, W. & Hughes, D. P., Nov 2017.

Research output: Contribution to conferencePoster

18F-FDG-PET: A non-invasive tool for imaging colitis

Dmochowska, N., Campaniello, M. A., Mavrangelos, C., Wardill, H. R., Keller, M., Tieu, W. & Hughes, P., 2017.

Research output: Contribution to conferencePoster

Dimeric and trimeric homo- and heteroleptic hydroxamic acid macrocycles formed using mixed-ligand Fe(III)-based metal-templated synthesis

Sresutharsan, A., Tieu, W., Richardson-Sanchez, T., Soe, C. Z. & Codd, R., 1 Dec 2017, In : Journal of Inorganic Biochemistry. 177, p. 344-351 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Exploiting the biosynthetic machinery of: Streptomyces pilosus to engineer a water-soluble zirconium(IV) chelator

Richardson-Sanchez, T., Tieu, W., Gotsbacher, M. P., Telfer, T. J. & Codd, R., 2017, In : Organic and Biomolecular Chemistry. 15, 27, p. 5719-5730 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products

Richardson-Sanchez, T., Tieu, W. & Codd, R., 16 Feb 2017, In : ChemBioChem. 18, 4, p. 368-373 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

A biomimetic synthetic approach to the frondosins

Kuan, K., Hirschvogel, A. M. C. & George, J. H., 1 Jan 2016, In : Australian Journal of Chemistry. 69, 12, p. 1420-1423 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

GEANT4 simulation of cyclotron radioisotope production in a solid target

Poignant, F., Penfold, S., Asp, J., Takhar, P. & Jackson, P., 1 May 2016, In : Physica Medica. 32, 5, p. 728-734 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015
13 Citations (Scopus)

Total Synthesis and Structure Revision of (-)-Siphonodictyal B and Its Biomimetic Conversion into (+)-Liphagal

Markwell-Heys, A. W., Kuan, K. & George, J. H., 21 Aug 2015, In : Organic Letters. 17, 17, p. 4228-4231 4 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2014

Biomimetic total synthesis of (±)-yezo'otogirin A

Lam, H. C., Kuan, K. & George, J. H., 28 Apr 2014, In : Organic and Biomolecular Chemistry. 12, 16, p. 2519-2522 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase

Tieu, W., Jarrad, A. M., Paparella, A. S., Keeling, K. A., Soares Da Costa, T. P., Wallace, J. C., Booker, G. W., Polyak, S. W. & Abell, A. D., 1 Oct 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 19, p. 4689-4693 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2013

Characterisation of a real-time fibre-coupled beryllium oxide (BeO) luminescence dosimeter in X-ray beams

Santos, A. M. C., Mohammadi, M., Asp, J., Monro, T. M. & Afshar V., S., 1 Jun 2013, In : Radiation Measurements. 53-54, p. 1-7 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model

Kerbler, G. M., Hamlin, A. S., Pannek, K., Kurniawan, N. D., Keller, M. D., Rose, S. E. & Coulson, E. J., 1 Feb 2013, In : NeuroImage. 66, p. 133-141 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

NMR-based metabonomics of bovine blood: An investigation into the effects of long term storage on plasma samples

Trabi, M., Keller, M. D. & Jonsson, N. N., 1 Oct 2013, In : Metabolomics. 9, 5, p. 1041-1047 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Optimising in situ click chemistry: The screening and identification of biotin protein ligase inhibitors

Tieu, W., Soares Da Costa, T. P., Yap, M. Y., Keeling, K. L., Wilce, M. C. J., Wallace, J. C., Booker, G. W., Polyak, S. W. & Abell, A. D., Sep 2013, In : Chemical Science. 4, 9, p. 3533-3537 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2012

5-Benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials

Zvarec, O., Polyak, S. W., Tieu, W., Kuan, K., Dai, H., Pedersen, D. S., Morona, R., Zhang, L., Booker, G. W. & Abell, A. D., 15 Apr 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 8, p. 2720-2722 3 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

Soares Da Costa, T. P., Tieu, W., Yap, M. Y., Zvarec, O., Bell, J. M., Turnidge, J. D., Wallace, J. C., Booker, G. W., Wilce, M. C. J., Abell, A. D. & Polyak, S. W., 14 May 2012, In : ACS Medicinal Chemistry Letters. 3, 6, p. 509-514 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Evaluation of physician eye lens doses during permanent seed implant brachytherapy for prostate cancer

Penfold, S. N., Marcu, L., Lawson, J. M. & Asp, J., 1 Sep 2012, In : Journal of Radiological Protection. 32, 3, p. 339-347 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images

Ullmann, J. F. P., Keller, M., Watson, C., Janke, A. L., Kurniawan, N. D., Yang, Z., Richards, K., Paxinos, G., Egan, G. F., Petrou, S., Bartlett, P., Galloway, G. J. & Reutens, D. C., 1 Sep 2012, In : NeuroImage. 62, 3, p. 1408-1414 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Selective inhibition of biotin protein ligase from Staphylococcus aureus

Soares Da Costa, T. P., Tieu, W., Yap, M. Y., Pendini, N. R., Polyak, S. W., Pedersen, D. S., Morona, R., Turnidge, J. D., Wallace, J. C., Wilce, M. C. J., Booker, G. W. & Abell, A. D., 18 May 2012, In : Journal of Biological Chemistry. 287, 21, p. 17823-17832 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Synthesis of a liphagal-frondosin c hybrid and speculation on the biosynthesis of the frondosins

Pepper, H. P., Kuan, K. & George, J. H., 16 Mar 2012, In : Organic Letters. 14, 6, p. 1524-1527 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Total synthesis of (+)-aureol

Kuan, K., Pepper, H. P., Bloch, W. M. & George, J. H., 21 Sep 2012, In : Organic Letters. 14, 18, p. 4710-4713 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2011

Diamond in tellurite glass: A new medium for quantum information

Henderson, M. R., Gibson, B. C., Ebendorff-Heidepriem, H., Kuan, K., Afshar V., S., Orwa, J. O., Aharonovich, I., Tomljenovic-Hanic, S., Greentree, A. D., Prawer, S. & Monro, T. M., 5 Jul 2011, In : Advanced Materials. 23, 25, p. 2806-2810 5 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Fabrication of depressed cladding waveguide Bragg-gratings in rare-earth doped heavy-metal fluoride glass

Gross, S., Lancaster, D. G., Ebendorff-Heidepriem, H., Kuan, K., Monro, T. M., Withford, M. J. & Fuerbach, A., 6 Sep 2011, 2011 Conference on Lasers and Electro-Optics Europe and 12th European Quantum Electronics Conference, CLEO EUROPE/EQEC 2011. 5943324. (2011 Conference on Lasers and Electro-Optics Europe and 12th European Quantum Electronics Conference, CLEO EUROPE/EQEC 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds

Heng, S., Tieu, W., Hautmann, S., Kuan, K., Pedersen, D. S., Pietsch, M., Gütschow, M. & Abell, A. D., 15 Dec 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7453-7463 11 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Segmentation of the mouse hippocampal formation in magnetic resonance images

Richards, K., Watson, C., Buckley, R. F., Kurniawan, N. D., Yang, Z., Keller, M., Beare, R., Bartlett, P. F., Egan, G. F., Galloway, G. J., Paxinos, G., Petrou, S. & Reutens, D. C., 1 Oct 2011, In : NeuroImage. 58, 3, p. 732-740 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Single photon emission from nanodiamond in tellurite glass

Gibson, B. C., Henderson, M. R., Ebendorff-Heidepriem, H., Kuan, K., Afshar, V. S., Orwa, J. O., Aharonovich, I., Tomljenovic-Hanic, S., Prawer, S., Monro, T. M. & Greentree, A. D., 2011, International Quantum Electronics Conference, IQEC 2011. p. 721-722 2 p. 6193950

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2009

APOMAB®, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

Al-Ejeh, F., Darby, J. M., Tsopelas, C., Smyth, D., Manavis, J. & Brown, M. P., 27 Feb 2009, In : PloS one. 4, 2, e4558.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2003

Crystal structures of fusion proteins with large-affinity tags

Smyth, D. R., Mrozkiewicz, M. K., McGrath, W. J., Listwan, P. & Kobe, B., 1 Jul 2003, In : Protein Science. 12, 7, p. 1313-1322 10 p.

Research output: Contribution to journalReview article

185 Citations (Scopus)
2002

Crystal structure of benzamide-2-thiolato(tri-o-tolylphosphine)gold(I), C28H27AUNOPS

Smyth, D. R. & Tiekink, E. R. T., 1 Dec 2002, In : Zeitschrift fur Kristallographie - New Crystal Structures. 217, 1, p. 357-358 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
3 Citations (Scopus)
2001

Cytotoxicity of triorganophosphinegold(I) complexes of thiobenzoate

Vincent, B. R., Clarke, D. J., Smyth, D., De Vos, D. & Tiekink, E. R. T., 1 Jan 2001, In : Metal-Based Drugs. 8, 2, p. 79-84 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cytotoxicity of triorganophosphinegold(I) n-mercaptobenzoates, n = 2, 3 and 4

De Vos, D., Smyth, D. R. & Tiekink, E. R. T., 1 Jan 2001, In : Metal-Based Drugs. 8, 6, p. 303-306 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2000

Crystal structure of catena-poly-(μ-acetato)triphenyltin-chloroform (2/1), Ph3Sn(O2CMe) · 0.5CHCl3

Smyth, D. & Tiekink, E. R. T., 1 Jan 2000, In : Zeitschrift fur Kristallographie - New Crystal Structures. 215, 1, p. 79-80 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Crystal structure of catena-poly-(μ-dichloroacetato)triphenyltin, [Ph3Sn(O2CHCl2)]n

Smyth, D. & Tiekink, E. R. T., 1 Jan 2000, In : Zeitschrift fur Kristallographie - New Crystal Structures. 215, 1, p. 81-82 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1999

Characterisation and in vitro cytotoxicity of triorganophosphinegold(I) 2-mercaptobenzoate complexes

De Vos, D., Clements, P., Pyke, S. M., Smyth, D. R. & Tiekink, E. R. T., 1 Jun 1999, In : Metal-Based Drugs. 6, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
1998
15 Citations (Scopus)